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scid Thymocytes with TCRß Gene Rearrangements Are Targets for the Oncogenic Effect of SCL and LMO1 Transgenes¹

Genetics Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892 [D. H. L., M. P. M., P. D. A.], and Departments of Cancer Genetics [D. S. C.], Immunology [D. H. L.], and Molecular and Cellular Biology [K. W. G.], Roswell Park Cancer Institute, Buffalo, New York 14263

SCL and LMO1 were both discovered by virtue of their activation by chromosomaltranslocation in patients with T-cell acute lymphoblastic leukemia (T-ALL). Overexpression of SCL and LMO1 in the thymus of transgenic mice leads to T-ALL at a young age. scid (severe combined immunodeficient) mice are unable to efficiently recombine antigen receptor genes and consequently display a developmental block at the CD4-CD8- to CD4+CD8+ transition. To test the hypothesis that this developmental block would protect SCL/LMO1 transgenic mice from developing T-ALL, we crossed the SCL and LMO1 transgenes onto a scid background. The age of onset for T-ALL in the SCL/LMO1/scid mice was significantly delayed (P < 0.001) compared with SCL/LMO1/wild-type mice. Intriguingly, all of the SCL/LMO1/scid malignancies displayed clonal, in-frame TCRß gene rearrangements. Taken together, these findings suggest that the "leaky" scid thymocyte that undergoes a productive TCRß gene rearrangement is susceptible to the oncogenic action of SCL and LMO1 and additionally suggests that TCRß gene rearrangements may be required for the oncogenic action of SCL and LMO1.

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