| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Tumor Biology |
Expression in Head and Neck Squamous Carcinoma and Inhibition by Anti-Epidermal Growth Factor Receptor Treatments1
Laboratory of Oncology Research, Medical Oncology Service [J. Al., J. C-S., F. R., J. M. D. C., J. An., J. B.]; Centre de Transfusió i Banc de Teixits [S. S.]; Maxillofacial Surgery Service [G. R.]; Radiation Oncology Service [J. G.]; Epidemiology Service [J. R.]; and Universidad Autónoma de Barcelona [G. R., J. G., J. B.], Vall d’Hebron University Hospital, Barcelona 08035, Spain; Tenovus Cancer Research Center, Department of Pharmacology, Welsh School of Pharmacy, University of Cardiff, Cardiff, CF13XF United Kingdom [R. I. N.]; and The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030-4009 [J. M.]
The expression of the activated mitogen-activated kinases/extracellular
signal-regulatedkinases (ERKs) ERK1 and ERK2 was characterized in 101
humanhead and neck squamous carcinoma specimens. Activated
ERK1/2were detected at different levels in the majority of these tumors, as
assayed by immunostaining with an antibody specific for the dually
phosphorylated and activated ERK1 and ERK2. ERK1/2 activation levels
were higher in tumors with advanced regional lymph node metastasis
(P = 0.048) and in relapsed tumors
(P = 0.021). The expression of epidermal
growth factor (EGF) receptor (P = 0.037),
transforming growth factor 
(TGF-; P < 0.001), and HER2 (P = 0.066;
positive trend) correlated with activation of ERK1/2. In a multivariate
analysis, both TGF- (P < 0.0001) and
HER2 (P = 0.045) were independently
correlated with ERK1/2 activation. In turn, activation of ERK1/2 was
associated with a higher Ki-67 proliferative index
(P = 0.002). In EGF receptor-dependent
model cells (A431 and DiFi), a specific EGF receptor tyrosine kinase
inhibitor ("Iressa"; ZD1839) and a chimeric anti-EGF receptor
antibody ("Cetuximab"; C225) inhibited ERK 1/2 activation at
concentrations that inhibited autocrine cell proliferation. In patients
on treatment with C225, the activation of ERK1/2 in skin, an EGF
receptor-dependent tissue, was lower compared with control skin.
Parallel changes were seen in keratinocyte Ki67 proliferation indexes
in skin from C225-treated patients. Taken together, these studies
provide support for a role of activation of ERK1/2 in head and neck
squamous carcinoma and a correlation with EGF receptor/TGF-
expression. The inhibition of ERK1/2 activation in vitro
and in vivo by compounds targeting the EGF receptor
points to the interest of ERK1/2 as potential surrogate markers of
EGF-receptor signaling in clinical therapeutic studies.
This article has been cited by other articles:
|
|
 |
|
  A. R. Raimondi, A. Molinolo, and J. S. Gutkind Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model Cancer Res., May 15, 2009; 69(10): 4159 - 4166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Rojo, I. Gonzalez-Navarrete, R. Bragado, A. Dalmases, S. Menendez, M. Cortes-Sempere, C. Suarez, C. Oliva, S. Servitja, V. Rodriguez-Fanjul, et al. Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin Clin. Cancer Res., May 15, 2009; 15(10): 3530 - 3539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Mutsaers, G. Francia, S. Man, C. R. Lee, J. M.L. Ebos, Y. Wu, L. Witte, S. Berry, M. Moore, and R. S. Kerbel Dose-Dependent Increases in Circulating TGF-{alpha} and Other EGFR Ligands Act As Pharmacodynamic Markers for Optimal Biological Dosing of Cetuximab and Are Tumor Independent Clin. Cancer Res., April 1, 2009; 15(7): 2397 - 2405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. AGUZZI, D. MAGGIONI, G. NICOLINI, G. TREDICI, R. M. GAINI, and W. GARAVELLO MAP Kinase Modulation in Squamous Cell Carcinoma of the Oral Cavity Anticancer Res, January 1, 2009; 29(1): 303 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Michaelis, J. Bliss, S. C. Arnold, N. Hinsch, F. Rothweiler, H. E. Deubzer, O. Witt, K. Langer, H. W. Doerr, W. S. Wels, et al. Cisplatin-Resistant Neuroblastoma Cells Express Enhanced Levels of Epidermal Growth Factor Receptor (EGFR) and Are Sensitive to Treatment with EGFR-Specific Toxins Clin. Cancer Res., October 15, 2008; 14(20): 6531 - 6537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M West, L Joseph, and S Bhana Epidermal growth factor receptor-targeted therapy Br. J. Radiol., October 1, 2008; 81(Special_Issue_1): S36 - S44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Morgillo, E. Martinelli, T. Troiani, G. Laus, S. Pepe, C. Gridelli, and F. Ciardiello Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase C{beta} inhibitor, in non-small cell lung cancer cells Mol. Cancer Ther., June 1, 2008; 7(6): 1698 - 1707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Arcidiacono, T. Sato, D. Alvarez-Hernandez, J. Yang, M. Tokumoto, I. Gonzalez-Suarez, Y. Lu, Y. Tominaga, J. Cannata-Andia, E. Slatopolsky, et al. EGFR Activation Increases Parathyroid Hyperplasia and Calcitriol Resistance in Kidney Disease J. Am. Soc. Nephrol., February 1, 2008; 19(2): 310 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tabernero, P. Pfeiffer, and A. Cervantes Administration of Cetuximab Every 2 Weeks in the Treatment of Metastatic Colorectal Cancer: An Effective, More Convenient Alternative to Weekly Administration? Oncologist, February 1, 2008; 13(2): 113 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Gross, J. O. Boyle, B. Du, V. D. Kekatpure, A. Lantowski, H. T. Thaler, B. B. Weksler, K. Subbaramaiah, and A. J. Dannenberg Inhibition of Jun NH2-Terminal Kinases Suppresses the Growth of Experimental Head and Neck Squamous Cell Carcinoma Clin. Cancer Res., October 1, 2007; 13(19): 5910 - 5917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Koyama, Y. Matsuzaki, S. Yogosawa, T. Hitomi, M. Kawanaka, and T. Sakai ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway Mol. Cancer Ther., May 1, 2007; 6(5): 1579 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cruz, A Ocana, E Del Barco, and A Pandiella Targeting receptor tyrosine kinases and their signal transduction routes in head and neck cancer Ann. Onc., March 1, 2007; 18(3): 421 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Rojo, L. Najera, J. Lirola, J. Jimenez, M. Guzman, M. D. Sabadell, J. Baselga, and S. R. y Cajal 4E-Binding Protein 1, A Cell Signaling Hallmark in Breast Cancer that Correlates with Pathologic Grade and Prognosis Clin. Cancer Res., January 1, 2007; 13(1): 81 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V. Wattenberg Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis Am J Physiol Cell Physiol, January 1, 2007; 292(1): C24 - C32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Birle and D. W. Hedley Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenografts. Mol. Cancer Ther., October 1, 2006; 5(10): 2494 - 2502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Melo, M. W. Gerbase, J. Curran, and J.-C. Pache Phosphorylated Extracellular Signal-regulated Kinases Are Significantly Increased in Malignant Mesothelioma J. Histochem. Cytochem., August 1, 2006; 54(8): 855 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Cunningham, H. Thomas, Z. Fan, and H. Modjtahedi Responses of Human Colorectal Tumor Cells to Treatment with the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody ICR62 Used Alone and in Combination with the EGFR Tyrosine Kinase Inhibitor Gefitinib. Cancer Res., August 1, 2006; 66(15): 7708 - 7715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. W. Cohen, M. W. Lingen, B. Zhu, H. Zhu, M. W. Straza, C. Pierce, L. E. Martin, and M. R. Rosner Protein Kinase C{zeta} Mediates Epidermal Growth Factor-Induced Growth of Head and Neck Tumor Cells by Regulating Mitogen-Activated Protein Kinase. Cancer Res., June 15, 2006; 66(12): 6296 - 6303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kalyankrishna and J. R. Grandis Epidermal Growth Factor Receptor Biology in Head and Neck Cancer J. Clin. Oncol., June 10, 2006; 24(17): 2666 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Codony-Servat, M. A. Tapia, M. Bosch, C. Oliva, J. Domingo-Domenech, B. Mellado, M. Rolfe, J. S. Ross, P. Gascon, A. Rovira, et al. Differential cellular and molecular effects of bortezomib, a proteasome inhibitor, in human breast cancer cells. Mol. Cancer Ther., March 1, 2006; 5(3): 665 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhou, S. Li, Y. P. Hu, J. Wang, J. Hauser, A. N. Conway, M. A. Vinci, L. Humphrey, E. Zborowska, J. K.V. Willson, et al. Blockade of EGFR and ErbB2 by the Novel Dual EGFR and ErbB2 Tyrosine Kinase Inhibitor GW572016 Sensitizes Human Colon Carcinoma GEO Cells to Apoptosis Cancer Res., January 1, 2006; 66(1): 404 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E.W. Cohen, M. A. Kane, M. A. List, B. E. Brockstein, B. Mehrotra, D. Huo, A. M. Mauer, C. Pierce, A. Dekker, and E. E. Vokes Phase II Trial of Gefitinib 250 mg Daily in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Clin. Cancer Res., December 1, 2005; 11(23): 8418 - 8424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cozzolino, Y. Lu, T. Sato, J. Yang, I. G. Suarez, D. Brancaccio, E. Slatopolsky, and A. S. Dusso A critical role for enhanced TGF-{alpha} and EGFR expression in the initiation of parathyroid hyperplasia in experimental kidney disease Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1096 - F1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Montagut, J. J. Grau, R. Grimalt, J. Codony, J. Ferrando, and J. Albanell Abnormal Hair Growth in a Patient With Head and Neck Cancer Treated With the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Cetuximab J. Clin. Oncol., August 1, 2005; 23(22): 5273 - 5275. [Full Text] [PDF]
|
|
|
|
|
|
F. R. Luo, Z. Yang, H. Dong, A. Camuso, K. McGlinchey, K. Fager, C. Flefleh, D. Kan, I. Inigo, S. Castaneda, et al. Prediction of Active Drug Plasma Concentrations Achieved in Cancer Patients by Pharmacodynamic Biomarkers Identified from the Geo Human Colon Carcinoma Xenograft Model Clin. Cancer Res., August 1, 2005; 11(15): 5558 - 5565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Henson, R. R. Neubig, I. Jang, T. Ogawa, Z. Zhang, T. E. Carey, and N. J. D'Silva Galanin Receptor 1 Has Anti-proliferative Effects in Oral Squamous Cell Carcinoma J. Biol. Chem., June 17, 2005; 280(24): 22564 - 22571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Spector, W. Xia, H. Burris III, H. Hurwitz, E. C. Dees, A. Dowlati, B. O'Neil, B. Overmoyer, P. K. Marcom, K. L. Blackwell, et al. Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies J. Clin. Oncol., April 10, 2005; 23(11): 2502 - 2512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Baselga and C. L. Arteaga Critical Update and Emerging Trends in Epidermal Growth Factor Receptor Targeting in Cancer J. Clin. Oncol., April 10, 2005; 23(11): 2445 - 2459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dasgupta, Y. Yi, D. Y. Chen, J. D. Weber, and D. H. Gutmann Proteomic Analysis Reveals Hyperactivation of the Mammalian Target of Rapamycin Pathway in Neurofibromatosis 1-Associated Human and Mouse Brain Tumors Cancer Res., April 1, 2005; 65(7): 2755 - 2760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Moraitis, B. Du, M. S. De Lorenzo, J. O. Boyle, B. B. Weksler, E. G. Cohen, J. F. Carew, N. K. Altorki, L. Kopelovich, K. Subbaramaiah, et al. Levels of Cyclooxygenase-2 Are Increased in the Oral Mucosa of Smokers: Evidence for the Role of Epidermal Growth Factor Receptor and Its Ligands Cancer Res., January 15, 2005; 65(2): 664 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention J. Clin. Oncol., January 10, 2005; 23(2): 254 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Vokes Current treatments and promising investigations in a multidisciplinary setting Ann. Onc., January 1, 2005; 16(suppl_6): vi25 - vi30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Matheson, J. P. McNamee, T. Wang, M. A. Alaoui-Jamali, A. M. Tari, and B. J. Jean-Claude The Combi-Targeting Concept: Dissection of the Binary Mechanism of Action of the Combi-Triazene SMA41 in Vitro and Antitumor Activity in Vivo J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1163 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Matar, F. Rojo, R. Cassia, G. Moreno-Bueno, S. Di Cosimo, J. Tabernero, M. Guzman, S. Rodriguez, J. Arribas, J. Palacios, et al. Combined Epidermal Growth Factor Receptor Targeting with the Tyrosine Kinase Inhibitor Gefitinib (ZD1839) and the Monoclonal Antibody Cetuximab (IMC-C225): Superiority Over Single-Agent Receptor Targeting Clin. Cancer Res., October 1, 2004; 10(19): 6487 - 6501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wu, W. W.-L. Wong, F. Khosravi, M. D. Minden, and L. Z. Penn Blocking the Raf/MEK/ERK Pathway Sensitizes Acute Myelogenous Leukemia Cells to Lovastatin-Induced Apoptosis Cancer Res., September 15, 2004; 64(18): 6461 - 6468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Warmka, L. J. Mauro, and E. V. Wattenberg Mitogen-activated Protein Kinase Phosphatase-3 Is a Tumor Promoter Target in Initiated Cells That Express Oncogenic Ras J. Biol. Chem., August 6, 2004; 279(32): 33085 - 33092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Huang, E. A. Armstrong, S. Benavente, P. Chinnaiyan, and P. M. Harari Dual-Agent Molecular Targeting of the Epidermal Growth Factor Receptor (EGFR): Combining Anti-EGFR Antibody with Tyrosine Kinase Inhibitor Cancer Res., August 1, 2004; 64(15): 5355 - 5362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Amornphimoltham, V. Sriuranpong, V. Patel, F. Benavides, C. J. Conti, J. Sauk, E. A. Sausville, A. A. Molinolo, and J. S. Gutkind Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma: A Potential Target for UCN-01 Clin. Cancer Res., June 15, 2004; 10(12): 4029 - 4037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Cheung, M.-t. Ling, S. W. Tsao, Y.C. Wong, and X. Wang Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells Carcinogenesis, June 1, 2004; 25(6): 881 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vicent, M. Garayoa, J. M. Lopez-Picazo, M. D. Lozano, G. Toledo, F. B. J. M. Thunnissen, R. G. Manzano, and L. M. Montuenga Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients Clin. Cancer Res., June 1, 2004; 10(11): 3639 - 3649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yang, R. Bagheri-Yarmand, R.-A. Wang, L. Adam, V. V. Papadimitrakopoulou, G. L. Clayman, A. El-Naggar, R. Lotan, C. J. Barnes, W. K. Hong, et al. The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 (Iressa) Suppresses c-Src and Pak1 Pathways and Invasiveness of Human Cancer Cells Clin. Cancer Res., January 15, 2004; 10(2): 658 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Vanhoefer, M. Tewes, F. Rojo, O. Dirsch, N. Schleucher, O. Rosen, J. Tillner, A. Kovar, A. H. Braun, T. Trarbach, et al. Phase I Study of the Humanized Antiepidermal Growth Factor Receptor Monoclonal Antibody EMD72000 in Patients With Advanced Solid Tumors That Express the Epidermal Growth Factor Receptor J. Clin. Oncol., January 1, 2004; 22(1): 175 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nunes, C. Shi, and L. M. Greenberger Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes Mol. Cancer Ther., January 1, 2004; 3(1): 21 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
T. M. Grana, C. I. Sartor, and A. D. Cox Epidermal Growth Factor Receptor Autocrine Signaling in RIE-1 Cells Transformed by the Ras Oncogene Enhances Radiation Resistance Cancer Res., November 15, 2003; 63(22): 7807 - 7814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Mandell Phosphorylation State-Specific Antibodies: Applications in Investigative and Diagnostic Pathology Am. J. Pathol., November 1, 2003; 163(5): 1687 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Niwa, A. L. Wentzel, M. Li, W. E. Gooding, V. W. Y. Lui, and J. R. Grandis Antitumor Effects of Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck Clin. Cancer Res., October 15, 2003; 9(13): 5028 - 5035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lango, A. L. Wentzel, J. I. Song, S. Xi, D. E. Johnson, W. W. Lamph, L. Miller, and J. R. Grandis Responsiveness to the Retinoic Acid Receptor-selective Retinoid LGD1550 Correlates with Abrogation of Transforming Growth Factor {alpha}/Epidermal Growth Factor Receptor Autocrine Signaling in Head and Neck Squamous Carcinoma Cells Clin. Cancer Res., September 15, 2003; 9(11): 4205 - 4213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Kruger and K. B. Reddy Distinct Mechanisms Mediate the Initial and Sustained Phases of Cell Migration in Epidermal Growth Factor Receptor-Overexpressing Cells Mol. Cancer Res., September 1, 2003; 1(11): 801 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Handra-Luca, H. Bilal, J.-C. Bertrand, and P. Fouret Extra-Cellular Signal-Regulated ERK-1/ERK-2 Pathway Activation in Human Salivary Gland Mucoepidermoid Carcinoma: Association to Aggressive Tumor Behavior and Tumor Cell Proliferation Am. J. Pathol., September 1, 2003; 163(3): 957 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mendelsohn and J. Baselga Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer J. Clin. Oncol., July 15, 2003; 21(14): 2787 - 2799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Baselga Skin as a Surrogate Tissue for Pharmacodynamic End Points: Is It Deep Enough? Clin. Cancer Res., July 1, 2003; 9(7): 2389 - 2390. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Grunwald and M. Hidalgo Developing Inhibitors of the Epidermal Growth Factor Receptor for Cancer Treatment J Natl Cancer Inst, June 18, 2003; 95(12): 851 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Janmaat, F. A. E. Kruyt, J. A. Rodriguez, and G. Giaccone Response to Epidermal Growth Factor Receptor Inhibitors in Non-Small Cell Lung Cancer Cells: Limited Antiproliferative Effects and Absence of Apoptosis Associated with Persistent Activity of Extracellular Signal-regulated Kinase or Akt Kinase Pathways Clin. Cancer Res., June 1, 2003; 9(6): 2316 - 2326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. W. Cohen, F. Rosen, W. M. Stadler, W. Recant, K. Stenson, D. Huo, and E. E. Vokes Phase II Trial of ZD1839 in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck J. Clin. Oncol., May 15, 2003; 21(10): 1980 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Arteaga and J. Baselga Clinical Trial Design and End Points for Epidermal Growth Factor Receptor-targeted Therapies: Implications for Drug Development and Practice Clin. Cancer Res., May 1, 2003; 9(5): 1579 - 1589. [Full Text] [PDF]
|
|
|
|
|
|
C. J. Barnes, R. Bagheri-Yarmand, M. Mandal, Z. Yang, G. L. Clayman, W. K. Hong, and R. Kumar Suppression of Epidermal Growth Factor Receptor, Mitogen-activated Protein Kinase, and Pak1 Pathways and Invasiveness of Human Cutaneous Squamous Cancer Cells by the Tyrosine Kinase Inhibitor ZD1839 (Iressa) Mol. Cancer Ther., April 1, 2003; 2(4): 345 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Anido, P. Matar, J. Albanell, M. Guzman, F. Rojo, J. Arribas, S. Averbuch, and J. Baselga ZD1839, a Specific Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor, Induces the Formation of Inactive EGFR/HER2 and EGFR/HER3 Heterodimers and Prevents Heregulin Signaling in HER2-overexpressing Breast Cancer Cells Clin. Cancer Res., April 1, 2003; 9(4): 1274 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liao, R. Bucala, and R. A. Mitchell Adhesion-dependent Signaling by Macrophage Migration Inhibitory Factor (MIF) J. Biol. Chem., January 3, 2003; 278(1): 76 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Chegini and L. Kornberg Gonadotropin Releasing Hormone Analogue Therapy Alters Signal Transduction Pathways Involving Mitogen-Activated Protein and Focal Adhesion Kinases in Leiomyoma Reproductive Sciences, January 1, 2003; 10(1): 21 - 26. [Abstract] [PDF]
|
|
|
|
|
|
A. Gschwind, N. Prenzel, and A. Ullrich Lysophosphatidic Acid-induced Squamous Cell Carcinoma Cell Proliferation and Motility Involves Epidermal Growth Factor Receptor Signal Transactivation Cancer Res., November 1, 2002; 62(21): 6329 - 6336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Baselga, D. Rischin, M. Ranson, H. Calvert, E. Raymond, D.G. Kieback, S.B. Kaye, L. Gianni, A. Harris, T. Bjork, et al. Phase I Safety, Pharmacokinetic, and Pharmacodynamic Trial of ZD1839, a Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Five Selected Solid Tumor Types J. Clin. Oncol., November 1, 2002; 20(21): 4292 - 4302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Wakeling, S. P. Guy, J. R. Woodburn, S. E. Ashton, B. J. Curry, A. J. Barker, and K. H. Gibson ZD1839 (Iressa): An Orally Active Inhibitor of Epidermal Growth Factor Signaling with Potential for Cancer Therapy Cancer Res., October 15, 2002; 62(20): 5749 - 5754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Cordero, M. Cozzolino, Y. Lu, M. Vidal, E. Slatopolsky, P. D. Stahl, M. A. Barbieri, and A. Dusso 1,25-Dihydroxyvitamin D Down-regulates Cell Membrane Growth- and Nuclear Growth-promoting Signals by the Epidermal Growth Factor Receptor J. Biol. Chem., October 4, 2002; 277(41): 38965 - 38971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Janne, M. L. Taffaro, R. Salgia, and B. E. Johnson Inhibition of Epidermal Growth Factor Receptor Signaling in Malignant Pleural Mesothelioma Cancer Res., September 15, 2002; 62(18): 5242 - 5247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mendelsohn Targeting the Epidermal Growth Factor Receptor for Cancer Therapy J. Clin. Oncol., September 15, 2002; 20(90001): 1s - 13. [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Iordanov, R. J. Choi, O. P. Ryabinina, T.-H. Dinh, R. K. Bright, and B. E. Magun The UV (Ribotoxic) Stress Response of Human Keratinocytes Involves the Unexpected Uncoupling of the Ras-Extracellular Signal-Regulated Kinase Signaling Cascade from the Activated Epidermal Growth Factor Receptor Mol. Cell. Biol., August 1, 2002; 22(15): 5380 - 5394. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
