This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fujimori, M. Articles by Asahara, T. Search for Related Content PubMed PubMed Citation Articles by Fujimori, M. Articles by Asahara, T.

Accumulation of ß-Catenin Protein and Mutations in Exon 3 of ß-Catenin Gene in Gastrointestinal Carcinoid Tumor¹

Second Department of Surgery, Hiroshima University Faculty of Medicine, Hiroshima, Japan 734-8551

The molecular basis of carcinogenesis in gastrointestinal carcinoid tumors is not well understood. To clarify the contribution of the Wnt/ß-catenin signaling to this type of carcinogenesis, we investigated 72 cases of gastrointestinal carcinoid tumor both immunohistochemically and by direct sequencing of ß-catenin. Accumulation of ß-catenin in the cytoplasm and/or nucleus was observed in 57 cases (79.2%). We also detected mutations in exon 3 of ß-catenin in 27 cases (37.5%) and one mutation in APC (1.4%). Our results suggest that alterations in the Wnt/ß-catenin signaling pathway may be involved in the development of gastrointestinal carcinoid tumors.

This article has been cited by other articles:

				C Christopoulos, V Balatsos, E Rotas, I Karoumpalis, D Papavasileiou, G Kontogeorgos, S Dupasquier, A Calender, N Skandalis, and P Economopoulos The syndrome of gastric carcinoid and hyperparathyroidism: a family study and literature review Eur. J. Endocrinol., April 1, 2009; 160(4): 689 - 694. [Abstract] [Full Text] [PDF]

				S. Pizzi, C. Azzoni, E. Tamburini, L. Bottarelli, N. Campanini, T. D'Adda, G. Fellegara, T. V. Luong, C. Pasquali, G. Rossi, et al. Adenomatous polyposis coli alteration in digestive endocrine tumours: correlation with nuclear translocation of {beta}-catenin and chromosomal instability Endocr. Relat. Cancer, December 1, 2008; 15(4): 1013 - 1024. [Abstract] [Full Text] [PDF]

				P. H. Abbosh, S. Zhang, G. T. MacLennan, R. Montironi, A. Lopez-Beltran, J. P. Rank, L. A. Baldridge, and L. Cheng Germ Cell Origin of Testicular Carcinoid Tumors Clin. Cancer Res., March 1, 2008; 14(5): 1393 - 1396. [Abstract] [Full Text] [PDF]

				Y. Wang, M. Giel-Moloney, G. Rindi, and A. B. Leiter Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin PNAS, July 3, 2007; 104(27): 11328 - 11333. [Abstract] [Full Text] [PDF]

				P. Bjorklund, G. Akerstrom, and G. Westin Accumulation of Nonphosphorylated {beta}-Catenin and c-myc in Primary and Uremic Secondary Hyperparathyroid Tumors J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 338 - 344. [Abstract] [Full Text] [PDF]

				M.-C. Su, C.-C. Wang, C.-C. Chen, R.-H. Hu, T.-H. Wang, H.-L. Kao, Y.-M. Jeng, and R.-H. Yuan Nuclear Translocation of {beta}-Catenin Protein but Absence of {beta}-Catenin and APC Mutation in Gastrointestinal Carcinoid Tumor Ann. Surg. Oncol., December 1, 2006; 13(12): 1604 - 1609. [Abstract] [Full Text] [PDF]

				V Hervieu, F Lepinasse, G Gouysse, O Guillaud, C Barel, M-L Chambonniere, P-P Bringuier, G Poncet, C Lombard-Bohas, C Partensky, et al. Expression of {beta}-catenin in gastroenteropancreatic endocrine tumours: a study of 229 cases J. Clin. Pathol., December 1, 2006; 59(12): 1300 - 1304. [Abstract] [Full Text] [PDF]

				S. J. Marx and W. F. Simonds Hereditary Hormone Excess: Genes, Molecular Pathways, and Syndromes Endocr. Rev., August 1, 2005; 26(5): 615 - 661. [Abstract] [Full Text] [PDF]

				H. Takeuchi, H. Fujita, F. Iwasaki, T. Takeuchi, K.-I. Imadome, T. Okumiya, T. Matsui, and M. Takahashi A Case of Epstein-Barr Virus (EBV)-Associated Thymic Carcinoid and Investigation of Existence of EBV-Infected Cells in Thymus and Thymic Tumors J. Clin. Microbiol., June 1, 2004; 42(6): 2850 - 2854. [Abstract] [Full Text] [PDF]

				S. Ikeda, Y. Shimizu, M. Fujimori, Y. Ishizaki, T. Kurihara, Y. Ojima, M. Okajima, and T. Asahara Immunohistochemical and Mutational Analyses of {beta}-catenin, Ki-ras, and p53 in Two Subtypes of Colorectal Mucinous Carcinoma Clin. Cancer Res., November 15, 2003; 9(15): 5660 - 5665. [Abstract] [Full Text] [PDF]

				E. J. Chung, S.-G. Hwang, P. Nguyen, S. Lee, J.-S. Kim, J. W. Kim, P. A. Henkart, D. P. Bottaro, L. Soon, P. Bonvini, et al. Regulation of leukemic cell adhesion, proliferation, and survival by beta -catenin Blood, July 18, 2002; 100(3): 982 - 990. [Abstract] [Full Text] [PDF]

				W. M. Clements, J. Wang, A. Sarnaik, O. J. Kim, J. MacDonald, C. Fenoglio-Preiser, J. Groden, and A. M. Lowy {beta}-Catenin Mutation Is a Frequent Cause of Wnt Pathway Activation in Gastric Cancer Cancer Res., June 1, 2002; 62(12): 3503 - 3506. [Abstract] [Full Text] [PDF]