Cancer Research SABCS Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mentor-Marcel, R.
Right arrow Articles by Elgavish, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mentor-Marcel, R.
Right arrow Articles by Elgavish, A.
[Cancer Research 61, 6777-6782, September 15, 2001]
© 2001 American Association for Cancer Research

Epidemiology and Prevention

Genistein in the Diet Reduces the Incidence of Poorly Differentiated Prostatic Adenocarcinoma in Transgenic Mice (TRAMP)1

Roycelynn Mentor-Marcel, Coral A. Lamartiniere, Isam-Eldin Eltoum, Norman M. Greenberg and Ada Elgavish2

Departments of Pharmacology/Toxicology [R. M-M., C. A. L.], Pathology [I-E. E.], and Genomics and Pathobiology [A. E.], University of Alabama at Birmingham, Birmingham, Alabama 35294, and Department of Molecular and Cellular Biology & Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030 [N. M. G.]

Latent prostate tumors are commonly found with similar frequency in many countries and ethnic groups. In contrast, aggressive prostate cancer (PC) is significantly less prevalent among Asian men, where the intake of soy products is very high. High consumption of foods containing soy results in high plasma, urine, and prostatic fluid concentrations of phytoestrogens, including genistein. The objective of the present study was to test the hypothesis that dietary genistein might prevent PC progression in a transgenic mouse model of PC (TRAMP). By 28–30 weeks of age, all TRAMP mice in the study had developed prostate tumors, with about half of them displaying well-differentiated prostatic adenocarcinoma (WD, score 4), and the other half divided between moderately differentiated (MD, score 5) and poorly differentiated adenocarcinoma (PD, score 6). Two lines of evidence supported the possibility that prostates with PD may represent a more advanced stage of PC in TRAMP mice: (a) the weight of prostates with PD was two orders of magnitude higher than that of prostates with WD or MD; and (b) expression of androgen receptor transcripts was altered in PD as compared with WD and MD. To test the potential of genistein to prevent the incidence of mice with PD, starting at 5–6 weeks of age, transgenic males were fed a phytoestrogen-free diet (AIN-76A) containing 0, 100, 250, or 500 mg of genistein per kg AIN-76A (25, 10, 17, and 7 mice/group, respectively). Mice were on the diet until they were 28–30 weeks of age. Each mouse was weighed once a week throughout the study. At necropsy, selected organs were weighed and prepared for histopathological evaluation. Serum levels of genistein in mice on diet containing 0, 250, or 500 mg of genistein per kg AIN-76A were 52.4 ± 32.7, 138.9 ± 69.6, and 397.3 ± 104.9 nM, respectively, comparable with those found in Asian men on regular soy diet (276 nM). Using body and organ weights as indicators, dietary genistein had no toxic effect on TRAMP mice. The percentage of transgenic males that developed PD was reduced in a dose-dependent manner by dietary genistein.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
L. H. El Touny and P. P. Banerjee
Identification of a Biphasic Role for Genistein in the Regulation of Prostate Cancer Growth and Metastasis
Cancer Res., April 15, 2009; 69(8): 3695 - 3703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
L. Yan and E. L Spitznagel
Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis
Am. J. Clinical Nutrition, April 1, 2009; 89(4): 1155 - 1163.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Smith, D. Sepkovic, H. L. Bradlow, and K. J. Auborn
3,3'-Diindolylmethane and Genistein Decrease the Adverse Effects of Estrogen in LNCaP and PC-3 Prostate Cancer Cells
J. Nutr., December 1, 2008; 138(12): 2379 - 2385.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
S. Shah, J. K. Hess-Wilson, S. Webb, H. Daly, S. Godoy-Tundidor, J. Kim, J. Boldison, Y. Daaka, and K. E. Knudsen
2,2-Bis(4-Chlorophenyl)-1,1-Dichloroethylene Stimulates Androgen Independence in Prostate Cancer Cells through Combinatorial Activation of Mutant Androgen Receptor and Mitogen-Activated Protein Kinase Pathways
Mol. Cancer Res., September 1, 2008; 6(9): 1507 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Raina, S. Rajamanickam, R. P. Singh, G. Deep, M. Chittezhath, and R. Agarwal
Stage-Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in Transgenic Adenocarcinoma of the Mouse Prostate Model
Cancer Res., August 15, 2008; 68(16): 6822 - 6830.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Liu, I.-E. A. Eltoum, B. Guo, B. H. Beck, G. A. Cloud, and R. D. Lopez
Protective Immunosurveillance and Therapeutic Antitumor Activity of {gamma}{delta} T Cells Demonstrated in a Mouse Model of Prostate Cancer
J. Immunol., May 1, 2008; 180(9): 6044 - 6053.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
G. P Risbridger, S. J Ellem, and S. J McPherson
Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling
J. Mol. Endocrinol., September 1, 2007; 39(3): 183 - 188.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. E. Harper, B. B. Patel, J. Wang, A. Arabshahi, I. A. Eltoum, and C. A. Lamartiniere
Resveratrol suppresses prostate cancer progression in transgenic mice
Carcinogenesis, September 1, 2007; 28(9): 1946 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
L. H. El Touny and P. P. Banerjee
Akt GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype
Carcinogenesis, August 1, 2007; 28(8): 1710 - 1717.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. M. Huffman, W. E. Grizzle, M. M. Bamman, J.-s. Kim, I. A. Eltoum, A. Elgavish, and T. R. Nagy
SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer
Cancer Res., July 15, 2007; 67(14): 6612 - 6618.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Raina, R. P. Singh, R. Agarwal, and C. Agarwal
Oral Grape Seed Extract Inhibits Prostate Tumor Growth and Progression in TRAMP Mice
Cancer Res., June 15, 2007; 67(12): 5976 - 5982.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. P. Kumar, S. Bhaskaran, M. Ganapathy, K. Crosby, M. D. Davis, P. Kochunov, J. Schoolfield, I-T. Yeh, D. A. Troyer, and R. Ghosh
Akt/cAMP-Responsive Element Binding Protein/Cyclin D1 Network: A Novel Target for Prostate Cancer Inhibition in Transgenic Adenocarcinoma of Mouse Prostate Model Mediated by Nexrutine, a Phellodendron Amurense Bark Extract
Clin. Cancer Res., May 1, 2007; 13(9): 2784 - 2794.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Yin, J. Ni, M. Chen, M. A. DiMaggio, Y. Guo, and S. Yeh
The Therapeutic and Preventive Effect of RRR-{alpha}-Vitamin E Succinate on Prostate Cancer via Induction of Insulin-Like Growth Factor Binding Protein-3
Clin. Cancer Res., April 1, 2007; 13(7): 2271 - 2280.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
W. A. Fritz, T.-M. Lin, R. D. Cardiff, and R. E. Peterson
The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice
Carcinogenesis, February 1, 2007; 28(2): 497 - 505.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. M. Huffman, M. S. Johnson, A. Watts, A. Elgavish, I. A. Eltoum, and T. R. Nagy
Cancer Progression in the Transgenic Adenocarcinoma of Mouse Prostate Mouse Is Related to Energy Balance, Body Mass, and Body Composition, but not Food Intake
Cancer Res., January 1, 2007; 67(1): 417 - 424.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Swami, A. V. Krishnan, J. Moreno, R. B. Bhattacharyya, D. M. Peehl, and D. Feldman
Calcitriol and Genistein Actions to Inhibit the Prostaglandin Pathway: Potential Combination Therapy to Treat Prostate Cancer
J. Nutr., January 1, 2007; 137(1): 205S - 210S.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A. S Perry, R. Foley, K. Woodson, and M. Lawler
The emerging roles of DNA methylation in the clinical management of prostate cancer.
Endocr. Relat. Cancer, June 1, 2006; 13(2): 357 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. E. Garcia, H.-G. Wisniewski, M. S. Lucia, N. Arevalo, T. J. Slaga, S. L. Kraft, R. Strange, and A. P. Kumar
2-Methoxyestradiol Inhibits Prostate Tumor Development in Transgenic Adenocarcinoma of Mouse Prostate: Role of Tumor Necrosis Factor-{alpha}-Stimulated Gene 6
Clin. Cancer Res., February 1, 2006; 12(3): 980 - 988.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
O. Imamov, G.-J. Shim, M. Warner, and J.-A. Gustafsson
Estrogen Receptor beta in Health and Disease
Biol Reprod, November 1, 2005; 73(5): 866 - 871.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Z. Fang, D. Chen, Y. Sun, Z. Jin, J. K. Christman, and C. S. Yang
Reversal of Hypermethylation and Reactivation of p16INK4a, RAR{beta}, and MGMT Genes by Genistein and Other Isoflavones from Soy
Clin. Cancer Res., October 1, 2005; 11(19): 7033 - 7041.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. Pollard and M. A. Suckow
Hormone-Refractory Prostate Cancer in the Lobund-Wistar Rat
Experimental Biology and Medicine, September 1, 2005; 230(8): 520 - 526.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. L. Goel, M. Breen, J. Zhang, I. Das, S. Aznavoorian-Cheshire, N. M. Greenberg, A. Elgavish, and L. R. Languino
{beta}1A Integrin Expression Is Required for Type 1 Insulin-Like Growth Factor Receptor Mitogenic and Transforming Activities and Localization to Focal Contacts
Cancer Res., August 1, 2005; 65(15): 6692 - 6700.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. Mentor-Marcel, C. A. Lamartiniere, I. A. Eltoum, N. M. Greenberg, and A. Elgavish
Dietary Genistein Improves Survival and Reduces Expression of Osteopontin in the Prostate of Transgenic Mice with Prostatic Adenocarcinoma (TRAMP)
J. Nutr., May 1, 2005; 135(5): 989 - 995.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
D. W. Voskuil, A. Vrieling, L. J. van't Veer, E. Kampman, and M. A. Rookus
The Insulin-like Growth Factor System in Cancer Prevention: Potential of Dietary Intervention Strategies
Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 195 - 203.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. D Lambert, J. Hong, G.-y. Yang, J. Liao, and C. S Yang
Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations
Am. J. Clinical Nutrition, January 1, 2005; 81(1): 284S - 291S.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty
Targeting Multiple Signaling Pathways as a Strategy for Managing Prostate Cancer: Multifocal Signal Modulation Therapy
Integr Cancer Ther, December 1, 2004; 3(4): 349 - 380.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
V. M. Adhami, I. A. Siddiqui, N. Ahmad, S. Gupta, and H. Mukhtar
Oral Consumption of Green Tea Polyphenols Inhibits Insulin-Like Growth Factor-I-Induced Signaling in an Autochthonous Mouse Model of Prostate Cancer
Cancer Res., December 1, 2004; 64(23): 8715 - 8722.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
G. G. Hillman, Y. Wang, O. Kucuk, M. Che, D. R. Doerge, M. Yudelev, M. C. Joiner, B. Marples, J. D. Forman, and F. H. Sarkar
Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
Mol. Cancer Ther., October 1, 2004; 3(10): 1271 - 1279.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Imamov, A. Morani, G.-J. Shim, Y. Omoto, C. Thulin-Andersson, M. Warner, and J.-A. Gustafsson
Estrogen receptor {beta} regulates epithelial cellular differentiation in the mouse ventral prostate
PNAS, June 22, 2004; 101(25): 9375 - 9380.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Gupta, V. M. Adhami, M. Subbarayan, G. T. MacLennan, J. S. Lewin, U. O. Hafeli, P. Fu, and H. Mukhtar
Suppression of Prostate Carcinogenesis by Dietary Supplementation of Celecoxib in Transgenic Adenocarcinoma of the Mouse Prostate Model
Cancer Res., May 1, 2004; 64(9): 3334 - 3343.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Hikosaka, M. Asamoto, N. Hokaiwado, K. Kato, K. Kuzutani, K. Kohri, and T. Shirai
Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
Carcinogenesis, March 1, 2004; 25(3): 381 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. W. Freeman, B. E. Welm, R. D. Gangula, J. M. Rosen, M. Ittmann, N. M. Greenberg, and D. M. Spencer
Inducible Prostate Intraepithelial Neoplasia with Reversible Hyperplasia in Conditional FGFR1-Expressing Mice
Cancer Res., December 1, 2003; 63(23): 8256 - 8263.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. M. Lee, S. L. Gomez, J. S. Chang, M. Wey, R.-T. Wang, and A. W. Hsing
Soy and Isoflavone Consumption in Relation to Prostate Cancer Risk in China
Cancer Epidemiol. Biomarkers Prev., July 1, 2003; 12(7): 665 - 668.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
W. A. Fritz, M. S. Cotroneo, J. Wang, I.-E. Eltoum, and C. A. Lamartiniere
Dietary Diethylstilbestrol but Not Genistein Adversely Affects Rat Testicular Development
J. Nutr., July 1, 2003; 133(7): 2287 - 2293.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. Yu, G. L. Blackburn, and J.-R. Zhou
Genistein and Daidzein Downregulate Prostate Androgen-Regulated Transcript-1 (PART-1) Gene Expression Induced by Dihydrotestosterone in Human Prostate LNCaP Cancer Cells
J. Nutr., February 1, 2003; 133(2): 389 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
A. Nyska, A. Suttie, S. Bakshi, L. Lomnitski, S. Grossman, M. Bergman, V. Ben-Shaul, P. Crocket, J. K. Haseman, G. Moser, et al.
Slowing Tumorigenic Progression in TRAMP Mice and Prostatic Carcinoma Cell Lines Using Natural Anti-Oxidant from Spinach, NAO--A Comparative Study of Three Anti-Oxidants
Toxicol Pathol, January 1, 2003; 31(1): 39 - 51.
[Abstract] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. A. Jarred, M. Keikha, C. Dowling, S. J. McPherson, A. M. Clare, A. J. Husband, J. S. Pedersen, M. Frydenberg, and G. P. Risbridger
Induction of Apoptosis in Low to Moderate-Grade Human Prostate Carcinoma by Red Clover-derived Dietary Isoflavones
Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1689 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
W. A. Fritz, I.-E. Eltoum, M. S. Cotroneo, and C. A. Lamartiniere
Genistein Alters Growth but Is Not Toxic to the Rat Prostate
J. Nutr., October 1, 2002; 132(10): 3007 - 3011.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. K. Day, A. M. Bauer, C. desBordes, Y. Zhuang, B.-E. Kim, L. G. Newton, V. Nehra, K. M. Forsee, R. S. MacDonald, C. Besch-Williford, et al.
Genistein Alters Methylation Patterns in Mice
J. Nutr., August 1, 2002; 132(8): 2419S - 2423.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. Messina, C. Gardner, and S. Barnes
Gaining Insight into the Health Effects of Soy but a Long Way Still to Go: Commentary on the Fourth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease
J. Nutr., March 1, 2002; 132(3): 547S - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. A. Lamartiniere, M. S. Cotroneo, W. A. Fritz, J. Wang, R. Mentor-Marcel, and A. Elgavish
Genistein Chemoprevention: Timing and Mechanisms of Action in Murine Mammary and Prostate
J. Nutr., March 1, 2002; 132(3): 552S - 558.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.