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Genetic Subgroups of Anaplastic Astrocytomas Correlate with Patient Age and Survival¹

Department of Neurosurgery [S. K., K. R. L., M. P., B. G. F.], Brain Tumor Research Center [G. M., B. G. F.], Department of Pathology, Division of Neuropathology [A. B.], Department of Laboratory Medicine and Cancer Genetics Program, University of California-San Francisco Cancer Center [B. G. F.], University of California, San Francisco, California 94143

Astrocytomas are brain tumors with variable responses to radiation and chemotherapy. Tumor grade and patient age are important prognostic factors but do not account for the variability in clinical outcome. We hypothesized that genetic subgroups play a role in the outcome of grade III astrocytomas and studied 80 grade III astrocytomas by comparative genomic hybridization. Some chromosomal aberrations (+7p/q, -9p, -10q, -13q, +19q) were related to aberrations that are frequent in grade IV astrocytoma, whereas others (+10p, -11q, +11p, -Xq) were more frequent in grade III astrocytoma. +7p, +19 and -4q were more frequent in tumors from older patients while -11p was more frequent in tumors from younger patients. Finally, gains of 7p and 7q were associated with shorter patient survival, independent of age. Our results indicate that genetic events underlie the well-known effects of age on survival in grade III astrocytoma and demonstrate the importance of molecular classification in astrocytic tumors.

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