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[Cancer Research 61, 7743-7746, November 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

High Frequency of Low-Level Microsatellite Instability in Early Colorectal Cancer1

Takeshi Kambara, Nagahide Matsubara2, Hitoshi Nakagawa, Kenji Notohara, Takeshi Nagasaka, Tadashi Yoshino, Hiroshi Isozaki, Gerald B. Sharp, Kenji Shimizu, Jeremy Jass and Noriaki Tanaka

Departments of Gastroenterological Surgery [T. K., N. M., H. N., T. N., H. I., N. T.], Pathology [K. N., T. Y.], and Molecular Genetics [N. M., K. S.], Okayama University Graduate School of Medicine, Okayama 700-8558, Japan; Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima 732-0815, Japan [G. B. S.]; and Department of Pathology, University of Queensland Graduate Medical School, Queensland 4006, Australia [J. J.]

Molecular events in early colorectal cancers (CRCs) have not been well elucidated because of the low incidence of early CRCs in clinical practice. Therefore, we studied 104 sporadic early CRCs with invasion limited to submucosa compared with 116 advanced CRCs. Loss of heterozygosity as well as microsatellite instability (MSI) status was examined. A significantly high frequency of low-level MSI (MSI-L) phenotype was detected in early CRCs (51.0%) compared with advanced CRCs (25.9%; P = 0.0001). In early and advanced CRCs, samples with MSI-L phenotype differed from microsatellite stable (MSS) phenotype with respect to loss of heterozygosity at 1p32 and 8p12–22. MSI-L is a frequent genetic event in early CRCs and may be a novel pathway in colorectal carcinogenesis distinct from both MSI-H and MSS.




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