Cancer Research Cancer Epigenetics Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hegde, P.
Right arrow Articles by Quackenbush, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hegde, P.
Right arrow Articles by Quackenbush, J.
[Cancer Research 61, 7792-7797, November 1, 2001]
© 2001 American Association for Cancer Research

Carcinogenesis

Identification of Tumor Markers in Models of Human Colorectal Cancer Using a 19,200-Element Complementary DNA Microarray1

Priti Hegde2, Rong Qi, Renee Gaspard, Kristie Abernathy, Sonia Dharap, Julie Earle-Hughes, Cheryl Gay, Nnenna U. Nwokekeh, Tingan Chen, Alexander I. Saeed, Vasily Sharov, Norman H. Lee, Timothy J. Yeatman3 and John Quackenbush3

The Institute for Genomic Research, Rockville, Maryland 20850 [P. H., R. Q., R. G., K. A., S. D., J. E-H., C. G., N. U. N., A. I. S., V. S., N. H. L., J. Q.], and H. Lee Moffitt Cancer Center, Tampa, Florida 33612 [T. C., T. J. Y.]

Metastasis represents a crucial transition in disease development and progression and has a profound impact on survival for a wide variety of cancers. Cell line models of metastasis have played an important role in developing our understanding of the metastatic process. We used a 19,200-element human cDNA microarray to profile transcription in three paired cell-line models of colorectal tumor metastasis. By correlating expression patterns across these cell lines, we have identified 176 genes that appear to be differentially expressed (greater than 2-fold) in all highly metastatic cell lines relative to their reference. An analysis of these genes reiterates much of our understanding of the metastatic process and suggests additional genes, many of previously uncharacterized function, that may be causatively involved in, or at least prognostic of, metastasis. Northern analysis of a limited number of these genes validates the observed pattern of expression and suggests that further investigation and functional characterization of the identified genes is warranted.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
L. Sabatino, A. Casamassimi, G. Peluso, M. V. Barone, D. Capaccio, C. Migliore, P. Bonelli, A. Pedicini, A. Febbraro, A. Ciccodicola, et al.
A Novel Peroxisome Proliferator-activated Receptor {gamma} Isoform with Dominant Negative Activity Generated by Alternative Splicing
J. Biol. Chem., July 15, 2005; 280(28): 26517 - 26525.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Benetti, T. Copetti, S. Dell'Orso, E. Melloni, C. Brancolini, M. Monte, and C. Schneider
The Calpain System Is Involved in the Constitutive Regulation of {beta}-Catenin Signaling Functions
J. Biol. Chem., June 10, 2005; 280(23): 22070 - 22080.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. Yan, Md. S. Jamaluddin, B. Aggarwal, J. Myers, and D. D. Boyd
Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin
Mol. Cancer Ther., February 1, 2005; 4(2): 233 - 241.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Engel, S. Mazurek, E. Eigenbrodt, and C. Welter
Phosphoglycerate Mutase-derived Polypeptide Inhibits Glycolytic Flux and Induces Cell Growth Arrest in Tumor Cell Lines
J. Biol. Chem., August 20, 2004; 279(34): 35803 - 35812.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L.-C. Chen, C.-Y. Hao, Y. S. Y. Chiu, P. Wong, J. S. Melnick, M. Brotman, J. Moretto, F. Mendes, A. P. Smith, J. L. Bennington, et al.
Alteration of Gene Expression in Normal-Appearing Colon Mucosa of APCmin Mice and Human Cancer Patients
Cancer Res., May 15, 2004; 64(10): 3694 - 3700.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Chen, I. Yang, R. Irby, K. H. Shain, H. G. Wang, J. Quackenbush, D. Coppola, J. Q. Cheng, and T. J. Yeatman
Regulation of Caspase Expression and Apoptosis by Adenomatous Polyposis Coli
Cancer Res., August 1, 2003; 63(15): 4368 - 4374.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. J. Hessner, X. Wang, S. Khan, L. Meyer, M. Schlicht, J. Tackes, M. W. Datta, H. J. Jacob, and S. Ghosh
Use of a three-color cDNA microarray platform to measure and control support-bound probe for improved data quality and reproducibility
Nucleic Acids Res., June 1, 2003; 31(11): e60 - e60.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
D. F. Jelinek, R. C. Tschumper, G. A. Stolovitzky, S. J. Iturria, Y. Tu, J. Lepre, N. Shah, and N. E. Kay
Identification of a Global Gene Expression Signature of B-Chronic Lymphocytic Leukemia
Mol. Cancer Res., March 1, 2003; 1(5): 346 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. S. Williams, R. B. Gaynor, S. Scoggin, U. Verma, T. Gokaslan, C. Simmang, J. Fleming, D. Tavana, E. Frenkel, and C. Becerra
Identification and Validation of Genes Involved in the Pathogenesis of Colorectal Cancer Using cDNA Microarrays and RNA Interference
Clin. Cancer Res., March 1, 2003; 9(3): 931 - 946.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. J. Hessner, X. Wang, K. Hulse, L. Meyer, Y. Wu, S. Nye, S.-W. Guo, and S. Ghosh
Three color cDNA microarrays: quantitative assessment through the use of fluorescein-labeled probes
Nucleic Acids Res., February 15, 2003; 31(4): e14 - e14.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Virtanen, Y. Ishikawa, D. Honjoh, M. Kimura, M. Shimane, T. Miyoshi, H. Nomura, and M. H. Jones
Integrated classification of lung tumors and cell lines by expression profiling
PNAS, September 17, 2002; 99(19): 12357 - 12362.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
F. Diehl, B. Beckmann, N. Kellner, N. C. Hauser, S. Diehl, and J. D. Hoheisel
Manufacturing DNA microarrays from unpurified PCR products
Nucleic Acids Res., August 15, 2002; 30(16): e79 - e79.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. F. Macgregor and J. A. Squire
Application of Microarrays to the Analysis of Gene Expression in Cancer
Clin. Chem., August 1, 2002; 48(8): 1170 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. V. Moses, M. A. Jarvis, C. Raggo, Y. C. Bell, R. Ruhl, B. G. M. Luukkonen, D. J. Griffith, C. L. Wait, B. J. Druker, M. C. Heinrich, et al.
Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-kit Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells
J. Virol., July 17, 2002; 76(16): 8383 - 8399.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Kuramoto, K. Morimura, S. Yamashita, E. Okochi, N. Watanabe, T. Ohta, M. Ohki, S. Fukushima, T. Sugimura, and T. Ushijima
Etiology-specific Gene Expression Profiles in Rat Mammary Carcinomas
Cancer Res., July 1, 2002; 62(13): 3592 - 3597.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.