Cancer Research Versailles No Abst Advances in Breast Cancer Research
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[Cancer Research 61, 8317-8321, November 15, 2001]
© 2001 American Association for Cancer Research

Tumor Biology

Increased p53 Mutation Frequency during Tumor Progression—Results from a Breast Cancer Cohort1

Torbjörn Norberg, Sigrid Klaar2, Gunilla Kärf, Hans Nordgren, Lars Holmberg and Jonas Bergh2,,3

Department of Oncology, Radiumhemmet, Karolinska Institute and Hospital, Stockholm, Sweden S-17176 [T. N., S. K., G. K., J. B.], and Department of Pathology [H. N.] and Regional Oncologic Center [L. H.], University of Uppsala, Akademiska sjukhuset, Uppsala, Sweden S-75185

The mutational patterns of the p53 gene for exons 4–9 were analyzed in 30 recurring tumors compared with the p53 status of the corresponding 30 primary breast cancers. The prevalence of p53 mutations was higher, although not statistically significant (P = 0.07), in the evaluable recurring tumors compared with the corresponding primaries, 12 of 29 (41%) versus 7 of 30 (23%). Twenty-one of the patients had unchanged p53 mutation status in the recurring compared with the primary tumors, whereas 8 had an altered mutational status or pattern in the sequential tumor. These findings indicate that p53 mutations may be an important factor for tumor progression in human breast cancer.




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Copyright © 2001 by the American Association for Cancer Research.