This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tanaka, Y. Articles by Kobayashi, Y. Search for Related Content PubMed PubMed Citation Articles by Tanaka, Y. Articles by Kobayashi, Y.

Frequent ß-Catenin Mutation and Cytoplasmic/Nuclear Accumulation in Pancreatic Solid-Pseudopapillary Neoplasm

Division of Pathology, Kanagawa Children’s Medical Center, Yokohama 232 [Y. T., K. K., R. I., T. M., Y. N.]; Department of Pathology, Okayama University, Okayama [K. N.]; Department of Pathology, Fukushima Prefectural University, Fukushima [H. H.]; Department of Environmental Medicine, Nihon Medical School, Nihon [N. N.]; Department of Pediatric Surgery, Hokkaido University, Hokkaido [F. S., N. K.]; and Division of Pathology, Osaka City General Medical Center, Osaka [Y. K.], Japan

Significance of Wnt signaling with ß-catenin mutations on solid-pseudopapillary neoplasm (SPN) of the pancreas was studied by immunohistochemistry and molecular analysis. On immunohistochemistry, all 18 SPNs tested showed diffuse cytoplasmic/nuclear positivity for ß-catenin. Upon direct DNA sequencing of exon 3 of the ß-catenin gene, 15 (83%) of the 18 SPNs showed 1-bp missense mutation in codons 32 (5 cases), 33 (3 cases), 34 (3 cases), 37 (3 cases), and 41 (1 case). Immunoreactivity for cyclin D1, one of the intranuclear targets of ß-catenin complexes, was found in tumor cells of more than half the tumor cells of all of the 18 SPNs. The present study strongly suggested a significant role of Wnt signaling, mostly associated with ß-catenin mutations in the tumorigenesis of SPN.

This article has been cited by other articles:

				S Serra and R Chetty Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas J. Clin. Pathol., November 1, 2008; 61(11): 1153 - 1159. [Abstract] [Full Text] [PDF]

				S. Nabais, J. C. Machado, C. Lopes, R. Seruca, F. Carneiro, and M. Sobrinho-Simoes Patterns of {beta}-Catenin Expression in Gastric Carcinoma: Clinicopathological Relevance and Mutation Analysis International Journal of Surgical Pathology, January 1, 2003; 11(1): 1 - 9. [Abstract] [PDF]

				S. C. Abraham, D. S. Klimstra, R. E. Wilentz, C. J. Yeo, K. Conlon, M. Brennan, J. L. Cameron, T.-T. Wu, and R. H. Hruban Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor {beta}-catenin Mutations Am. J. Pathol., April 1, 2002; 160(4): 1361 - 1369. [Abstract] [Full Text] [PDF]