| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Experimental Therapeutics |
-Fetoprotein-specific Tumor Immunity Induced by Plasmid Prime-Adenovirus Boost Genetic Vaccination1
Divisions of Surgical Oncology [W. S. M., L. H. B., A. R., V. B. D., J. B. H., G. A. M., J. S. E.], Hematology-Oncology [A. R., J. A. G.], Experimental Radiation Oncology [W. H. M.], and the Department of Microbiology, Immunology, and Molecular Genetics [J. S. E.], University of California, Los Angeles, Los Angeles, California 90095
-Fetoprotein (AFP) is a potential target for immunotherapy in hepatocellular carcinoma; both the murine and human T-cell repertoires can recognize AFP-derived epitopes in the context of the MHC. Protective immunity can be generated with AFP-engineered dendritic cell-based vaccines. We now report a DNA-based immunization strategy using a prime-boost approach: coadministration of plasmid DNA encoding murine AFP and murine granulocyte-macrophage colony-stimulating factor followed by boosting with an AFP-expressing nonreplicating adenoviral vector. This immunization strategy can elicit a high frequency of Th1-type AFP-specific cells leading to tumor protective immunity in mice at levels comparable with AFP-engineered dendritic cells. This cell-free mode of immunization is better suited for large-scale vaccine efforts for patients with hepatocellular carcinoma.
This article has been cited by other articles:
|
|
 |
|
  Y. Liu, S. Daley, V. N. Evdokimova, D. D. Zdobinski, D. M. Potter, and L. H. Butterfield Hierarchy of {alpha} Fetoprotein (AFP)-Specific T Cell Responses in Subjects with AFP-Positive Hepatocellular Cancer J. Immunol., July 1, 2006; 177(1): 712 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Butterfield, A. Ribas, V. B. Dissette, Y. Lee, J. Q. Yang, P. De la Rocha, S. D. Duran, J. Hernandez, E. Seja, D. M. Potter, et al. A Phase I/II Trial Testing Immunization of Hepatocellular Carcinoma Patients with Dendritic Cells Pulsed with Four {alpha}-Fetoprotein Peptides. Clin. Cancer Res., May 1, 2006; 12(9): 2817 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Krebs, E. Scandella, B. Odermatt, and B. Ludewig Rapid Functional Exhaustion and Deletion of CTL following Immunization with Recombinant Adenovirus J. Immunol., April 15, 2005; 174(8): 4559 - 4566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Lyerly Your Ad here: optimizing adenoviral vector-based vaccines Blood, November 1, 2004; 104(9): 2612 - 2613. [Full Text] [PDF]
|
|
|
|
|
|
M. Kuang, B. G. Peng, M. D. Lu, L. J. Liang, J. F. Huang, Q. He, Y. P. Hua, S. Totsuka, S. Q. Liu, K. W. Leong, et al. Phase II Randomized Trial of Autologous Formalin-Fixed Tumor Vaccine for Postsurgical Recurrence of Hepatocellular Carcinoma Clin. Cancer Res., March 1, 2004; 10(5): 1574 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lane, J. Leitch, X. Tan, J. Hadjati, J. L. Bramson, and Y. Wan Vaccination-Induced Autoimmune Vitiligo Is a Consequence of Secondary Trauma to the Skin Cancer Res., February 15, 2004; 64(4): 1509 - 1514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Butterfield, A. Ribas, W. S. Meng, V. B. Dissette, S. Amarnani, H. T. Vu, E. Seja, K. Todd, J. A. Glaspy, W. H. McBride, et al. T-Cell Responses to HLA-A*0201 Immunodominant Peptides Derived from {alpha}-Fetoprotein in Patients with Hepatocellular Cancer Clin. Cancer Res., December 1, 2003; 9(16): 5902 - 5908. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
