| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Regular Articles |
Laboratory of Population Genetics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 [K. W. H., L. L., D. C., J. R.]; Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205 [K. W. B.]; Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 [T. L. V.]; and Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033-2390 [M. T. D., D. R. W.]
Tumor metastasis is one of the most important clinical aspects of neoplastic disease because patient mortality is frequently attributable to disseminated rather than primary tumors. However, it still is not possible to definitively distinguish those individuals at high risk for disseminated disease, who would benefit from aggressive adjuvant therapy, from the low-risk patients who might be spared the side effects of additional anticancer therapy. To identify factors that predispose toward metastatic disease, we have used a genetic approach. Using a highly metastatic model of mammary cancer, we identified previously inbred mouse strains (DBA/2J, NZB/B1NJ, and I/LnJ) that harbor genetic factors that significantly suppress metastatic efficiency. In this study, we report the results of four experiments to localize the genetic map locations of the metastasis efficiency modifier genes. One statistically significant locus was identified on proximal Chr 19 designated Mtes1. Secondary candidate intervals were detected on Chrs 6, 9, 13, and 17. Interestingly, Mtes1 colocalizes with the murine orthologue of the human breast cancer metastasis suppressor gene Brms1, suggesting that allelic variants of Brms1 might be responsible for the metastasis suppression observed.
This article has been cited by other articles:
|
|
 |
|
  L. Lukes, N. P.S. Crawford, R. Walker, and K. W. Hunter The Origins of Breast Cancer Prognostic Gene Expression Profiles Cancer Res., January 1, 2009; 69(1): 310 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Martin, K. J. Carter, S. R. Jean-Philippe, M. Chang, S. Mobashery, S. Thiolloy, C. C. Lynch, L. M. Matrisian, and B. Fingleton Effect of Ablation or Inhibition of Stromal Matrix Metalloproteinase-9 on Lung Metastasis in a Breast Cancer Model Is Dependent on Genetic Background Cancer Res., August 1, 2008; 68(15): 6251 - 6259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P. S. Crawford, J. Alsarraj, L. Lukes, R. C. Walker, J. S. Officewala, H. H. Yang, M. P. Lee, K. Ozato, and K. W. Hunter Bromodomain 4 activation predicts breast cancer survival PNAS, April 29, 2008; 105(17): 6380 - 6385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Hicks, B. J. Yoder, S. Short, S. Tarr, N. Prescott, J. P. Crowe, A. E. Dawson, G. T. Budd, S. Sizemore, M. Cicek, et al. Loss of Breast Cancer Metastasis Suppressor 1 Protein Expression Predicts Reduced Disease-Free Survival in Subsets of Breast Cancer Patients. Clin. Cancer Res., November 15, 2006; 12(22): 6702 - 6708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Roth, M. Caunt, A. Cretu, A. Akalu, D. Policarpio, X. Li, P. Gagne, S. Formenti, and P. C. Brooks Inhibition of Experimental Metastasis by Targeting the HUIV26 Cryptic Epitope in Collagen Am. J. Pathol., May 1, 2006; 168(5): 1576 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Hunter and N. P. Crawford Germ Line Polymorphism in Metastatic Progression Cancer Res., February 1, 2006; 66(3): 1251 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Meehan, R. S. Samant, J. E. Hopper, M. J. Carrozza, L. A. Shevde, J. L. Workman, K. A. Eckert, M. F. Verderame, and D. R. Welch Breast Cancer Metastasis Suppressor 1 (BRMS1) Forms Complexes with Retinoblastoma-binding Protein 1 (RBP1) and the mSin3 Histone Deacetylase Complex and Represses Transcription J. Biol. Chem., January 9, 2004; 279(2): 1562 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yamamoto, M. Yang, P. Jiang, M. Xu, H. Tsuchiya, K. Tomita, A. R. Moossa, and R. M. Hoffman Determination of Clonality of Metastasis by Cell-Specific Color-Coded Fluorescent-Protein Imaging Cancer Res., November 15, 2003; 63(22): 7785 - 7790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Welch and K. W. Hunter A New Member of the Growing Family of Metastasis Suppressors Identified in Prostate Cancer J Natl Cancer Inst, June 18, 2003; 95(12): 839 - 841. [Full Text] [PDF]
|
|
|
|
|
|
T. A. Dragani 10 Years of Mouse Cancer Modifier Loci: Human Relevance Cancer Res., June 15, 2003; 63(12): 3011 - 3018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Broman Mapping Quantitative Trait Loci in the Case of a Spike in the Phenotype Distribution Genetics, March 1, 2003; 163(3): 1169 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-G. Park, R. Clifford, K. H. Buetow, and K. W. Hunter Multiple Cross and Inbred Strain Haplotype Mapping of Complex-Trait Candidate Genes Genome Res., January 1, 2003; 13(1): 118 - 121. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
