This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rubin, H. Search for Related Content PubMed PubMed Citation Articles by Rubin, H.

Selected Cell and Selective Microenvironment in Neoplastic Development

Department of Molecular and Cell Biology and Virus Laboratory Life Sciences Addition, University of California, Berkeley, California 94720-3200

Recent analysis of genetic alterations in human cancer points to a major role for selection in neoplastic development but provides few details about the dynamics of the process. Many such details, however, have emerged from quantitative studies of spontaneous transformation among mammalian cells in culture. The chief insight of these studies is that there is a continuous generation of variants in proliferative potential among growing cells that provides the substratum for progressive development to a frankly neoplastic state when selective growth conditions are persistently applied. Much of the selection occurs before the cells are capable of producing discrete neoplastic foci. The varied observations in cell culture draw attention to analogous features of carcinogenesis in experimental animals and the development of human cancer.

This article has been cited by other articles:

				D. Alley, S Langley-Turnbaugh, N. Gordon, J. Wise, G Van Epps, and A Jalbert The effect of PM10 on human lung fibroblasts Toxicology and Industrial Health, March 1, 2009; 25(2): 111 - 120. [Abstract] [PDF]

				J. Galle, D. Sittig, I. Hanisch, M. Wobus, E. Wandel, M. Loeffler, and G. Aust Individual Cell-Based Models of Tumor-Environment Interactions: Multiple Effects of CD97 on Tumor Invasion Am. J. Pathol., November 1, 2006; 169(5): 1802 - 1811. [Abstract] [Full Text] [PDF]

				O. Mendez, B. Martin, R. Sanz, R. Aragues, V. Moreno, B. Oliva, V. Stresing, and A. Sierra Underexpression of transcriptional regulators is common in metastatic breast cancer cells overexpressing Bcl-xL Carcinogenesis, June 1, 2006; 27(6): 1169 - 1179. [Abstract] [Full Text] [PDF]

				R. A. Gatenby and E. T. Gawlinski The Glycolytic Phenotype in Carcinogenesis and Tumor Invasion: Insights through Mathematical Models Cancer Res., July 15, 2003; 63(14): 3847 - 3854. [Abstract] [Full Text] [PDF]

				A. Musio, C. Montagna, D. Zambroni, E. Indino, O. Barbieri, L. Citti, A. Villa, T. Ried, and P. Vezzoni Inhibition of BUB1 Results in Genomic Instability and Anchorage-independent Growth of Normal Human Fibroblasts Cancer Res., June 1, 2003; 63(11): 2855 - 2863. [Abstract] [Full Text] [PDF]

				H. Rubin and G. R. Anderson Correspondence re: G. Anderson et al., Intrachromosomal Genomic Instability in Human Sporadic Colorectal Cancer Measured by Genome-Wide Allelotyping and Inter-(Simple Sequence Repeat) PCR. Cancer Res., 61: 8274-8283, 2001. Cancer Res., November 1, 2002; 62(21): 6350 - 6351. [Full Text] [PDF]

				R. A. Gatenby and B. R. Frieden Application of Information Theory and Extreme Physical Information to Carcinogenesis Cancer Res., July 1, 2002; 62(13): 3675 - 3684. [Abstract] [Full Text] [PDF]

				H. Rubin Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates Carcinogenesis, December 1, 2001; 22(12): 1903 - 1930. [Abstract] [Full Text] [PDF]

				G. R. Anderson, B. M. Brenner, H. Swede, N. Chen, W. M. Henry, J. M. Conroy, M. J. Karpenko, J.-P. Issa, J. D. Bartos, J. K. Brunelle, et al. Intrachromosomal Genomic Instability in Human Sporadic Colorectal Cancer Measured by Genome-Wide Allelotyping and Inter-(Simple Sequence Repeat) PCR Cancer Res., November 1, 2001; 61(22): 8274 - 8283. [Abstract] [Full Text] [PDF]

				M. Hanausek, P. Ganesh, Z. Walaszek, C. J. Arntzen, T. J. Slaga, and J. U. Gutterman From the Cover: Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model PNAS, September 25, 2001; 98(20): 11551 - 11556. [Abstract] [Full Text] [PDF]

				S. Laconi, P. Pani, S. Pillai, D. Pasciu, D. S. R. Sarma, and E. Laconi A growth-constrained environment drives tumor progression invivo PNAS, June 20, 2001; (2001) 131210498. [Abstract] [Full Text] [PDF]

				S. Laconi, P. Pani, S. Pillai, D. Pasciu, D. S. R. Sarma, and E. Laconi A growth-constrained environment drives tumor progression invivo PNAS, July 3, 2001; 98(14): 7806 - 7811. [Abstract] [Full Text] [PDF]