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[Cancer Research 61, 842-847, February 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Vaccination of Malignant Glioma Patients with Peptide-pulsed Dendritic Cells Elicits Systemic Cytotoxicity and Intracranial T-cell Infiltration1

John S. Yu, Christopher J. Wheeler, Paul M. Zeltzer, Han Ying, Divina N. Finger, Paul K. Lee, William H. Yong, Francesca Incardona, Reid C. Thompson, Mary S. Riedinger, Wenxuan Zhang, Robert M. Prins2 and Keith L. Black3

Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048 [J. S. Y., C. J. W., P. M. Z., H. Y., D. N. F., P. K. L., W. H. Y., F. I., R. C. T., M. S. R., W. Z., R. M. P., K. L. B.]; and Department of Neurological Surgery, University of California, Irvine, California 92868-3298 [J. S. Y., P. M. Z., R. C. T., K. L. B.]

In this Phase I trial, patients’ peripheral blood dendritic cells were pulsed with peptides eluted from the surface of autologous glioma cells. Three biweekly intradermal vaccinations of peptide-pulsed dendritic cells were administered to seven patients with glioblastoma multiforme and two patients with anaplastic astrocytoma. Dendritic cell vaccination elicited systemic cytotoxicity in four of seven tested patients. Robust intratumoral cytotoxic and memory T-cell infiltration was detected in two of four patients who underwent reoperation after vaccination. This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous peptide-pulsed dendritic cell vaccine for patients with malignant glioma.




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Copyright © 2001 by the American Association for Cancer Research.