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[Cancer Research 61, 912-915, February 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Telomere Length Abnormalities in Mammalian Radiosensitive Cells1

Joanne McIlrath, Simon D. Bouffler, Enrique Samper, Andrew Cuthbert, Andrzej Wojcik, Irena Szumiel, Peter E. Bryant, Andrew C. Riches, Alastair Thompson, Maria A. Blasco, Robert F. Newbold and Predrag Slijepcevic2

Department of Biological Sciences, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, United Kingdom [J. M., A. C., R. F. N., P. S.]; Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, United Kingdom [S. D. B.]; Department of Immunology and Oncology, Centro Nacional de Biotecnología- Consejo Superior de Investigaciones Cientificas, Madrid E-28049, Spain [E. S., M. A. B.]; Institute of Nuclear Chemistry and Technology, Department of Radiobiology and Health Protection, Dorodna 16, 03-195 Warszawa, Poland [A. W., I. S.]; School of Biology, St. Andrews University, St. Andrews, Fife, KY16 9TS, United Kingdom [P. E. B., A. C. R.]; and Ninewells Hospital, Dundee University, Dundee, Tayside, DD1 9SY, United Kingdom [A. T.]

Telomere lengths in radiosensitive murine lymphoma cells L5178Y-S and parental radioresistant L5178Y cells were measured by quantitative fluorescence in situ hybridization. Results revealed a 7-fold reduction in telomere length in radiosensitive cells (7 kb) in comparison with radioresistant cells (48 kb). Therefore, it was reasoned that telomere length might be used as a marker for chromosomal radiosensitivity. In agreement with this hypothesis, a significant inverse correlation between telomere length and chromosomal radiosensitivity was observed in lymphocytes from 24 breast cancer patients and 5 normal individuals. In contrast, no chromosomal radiosensitivity was observed in mouse cell lines that showed shortened telomeres, possibly reflecting differences in radiation responses between primary cells and established cell lines. Telomere length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked.




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Copyright © 2001 by the American Association for Cancer Research.