Cancer Research Meeting Calendar Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahmad, S. A.
Right arrow Articles by Ellis, L. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahmad, S. A.
Right arrow Articles by Ellis, L. M.
[Cancer Research 61, 1255-1259, February 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

The Effects of Angiopoietin-1 and -2 on Tumor Growth and Angiogenesis in Human Colon Cancer1

Syed A. Ahmad, Wenbiao Liu, Young D. Jung, Fan Fan, Michael Wilson, Niels Reinmuth, Raymond M. Shaheen, Corazon D. Bucana and Lee M. Ellis2

Departments of Surgical Oncology [S. A. A., R. M. S., L. M. E.] and Cancer Biology [W. L., Y. D. J., F. F., M. W., N. R., C. D. B., L. M. E.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

Angiopoietin (Ang) 1 and Ang-2 are important regulators of endothelial cell survival. Current models suggest that an increase in Ang-2 expression in endothelial cells leads to initiation of angiogenesis. We stably transfected HT29 colon cancer cells with cDNA constructs for Ang-1 or -2 or with vector alone, injected the cells s.c. into nude mice, and assessed tumor growth. Immunohistochemical analyses confirmed sustained increases of Ang-1 and -2 in the tumors. The tumors produced by the Ang-2-transfected cells were larger than the tumors produced in the other groups; those tumors also had higher vessel counts and proliferative indices than tumors in the other groups. Tumors produced by the Ang-1 transfectants had fewer vessels and lower tumor cell proliferative indices than tumors in the other groups. These data suggest that imbalances between Ang-1 and -2 that result in a net gain of Ang-2 activity lead to enhanced tumor angiogenesis and growth.




This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
B. L. Falcon, H. Hashizume, P. Koumoutsakos, J. Chou, J. V. Bready, A. Coxon, J. D. Oliner, and D. M. McDonald
Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels
Am. J. Pathol., November 1, 2009; 175(5): 2159 - 2170.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
R Srirajaskanthan, G Dancey, A Hackshaw, T Luong, M E Caplin, and T Meyer
Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis
Endocr. Relat. Cancer, September 1, 2009; 16(3): 967 - 976.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. S. Herbst, D. Hong, L. Chap, R. Kurzrock, E. Jackson, J. M. Silverman, E. Rasmussen, Y.-N. Sun, D. Zhong, Y. C. Hwang, et al.
Safety, Pharmacokinetics, and Antitumor Activity of AMG 386, a Selective Angiopoietin Inhibitor, in Adult Patients With Advanced Solid Tumors
J. Clin. Oncol., July 20, 2009; 27(21): 3557 - 3565.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
L. G. Strauss, D. Koczan, S. Klippel, L. Pan, C. Cheng, S. Willis, U. Haberkorn, and A. Dimitrakopoulou-Strauss
Impact of Angiogenesis-Related Gene Expression on the Tracer Kinetics of 18F-FDG in Colorectal Tumors
J. Nucl. Med., August 1, 2008; 49(8): 1238 - 1244.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
H. R. Lijnen
Angiogenesis and obesity
Cardiovasc Res, May 1, 2008; 78(2): 286 - 293.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
W. S.N. Shim, I. A.W. Ho, and P. E.H. Wong
Angiopoietin: A TIE(d) Balance in Tumor Angiogenesis
Mol. Cancer Res., July 1, 2007; 5(7): 655 - 665.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Cao, P. Sonveaux, S. Liu, Y. Zhao, J. Mi, B. M. Clary, C.-Y. Li, C. D. Kontos, and M. W. Dewhirst
Systemic Overexpression of Angiopoietin-2 Promotes Tumor Microvessel Regression and Inhibits Angiogenesis and Tumor Growth
Cancer Res., April 15, 2007; 67(8): 3835 - 3844.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Niu and W. B. Carter
Human Epidermal Growth Factor Receptor 2 Regulates Angiopoietin-2 Expression in Breast Cancer via AKT and Mitogen-Activated Protein Kinase Pathways
Cancer Res., February 15, 2007; 67(4): 1487 - 1493.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J Heidemann, D G Binion, W Domschke, and T Kucharzik
Antiangiogenic therapy in human gastrointestinal malignancies.
Gut, October 1, 2006; 55(10): 1497 - 1511.
[Full Text] [PDF]

Home page
 JNMHome page
P. Kunz, J. Hoffend, A. Altmann, A. Dimitrakopoulou-Strauss, D. Koczan, M. Eisenhut, G. A. Bonaterra, T. J. Dengler, W. Mier, U. Haberkorn, et al.
Angiopoietin-2 Overexpression in Morris Hepatoma Results in Increased Tumor Perfusion and Induction of Critical Angiogenesis-Promoting Genes
J. Nucl. Med., September 1, 2006; 47(9): 1515 - 1524.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. G. Trevino, J. M. Summy, D. P. Lesslie, N. U. Parikh, D. S. Hong, F. Y. Lee, N. J. Donato, J. L. Abbruzzese, C. H. Baker, and G. E. Gallick
Inhibition of Src Expression and Activity Inhibits Tumor Progression and Metastasis of Human Pancreatic Adenocarcinoma Cells in an Orthotopic Nude Mouse Model
Am. J. Pathol., March 1, 2006; 168(3): 962 - 972.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. G. Trevino, J. M. Summy, M. J. Gray, M. B. Nilsson, D. P. Lesslie, C. H. Baker, and G. E. Gallick
Expression and Activity of Src Regulate Interleukin-8 Expression in Pancreatic Adenocarcinoma Cells: Implications for Angiogenesis
Cancer Res., August 15, 2005; 65(16): 7214 - 7222.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. J. Gray, J. S. Wey, A. Belcheva, M. F. McCarty, J. G. Trevino, D. B. Evans, L. M. Ellis, and G. E. Gallick
Neuropilin-1 Suppresses Tumorigenic Properties in a Human Pancreatic Adenocarcinoma Cell Line Lacking Neuropilin-1 Coreceptors
Cancer Res., May 1, 2005; 65(9): 3664 - 3670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. Guo, Y. Imanishi, F. C. Cackowski, M. J. Jarzynka, H.-Q. Tao, R. Nishikawa, T. Hirose, B. Hu, and S.-Y. Cheng
Up-Regulation of Angiopoietin-2, Matrix Metalloprotease-2, Membrane Type 1 Metalloprotease, and Laminin 5 {gamma} 2 Correlates with the Invasiveness of Human Glioma
Am. J. Pathol., March 1, 2005; 166(3): 877 - 890.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Xu, Y.-j. Liu, and Q. Yu
Angiopoietin-3 Inhibits Pulmonary Metastasis by Inhibiting Tumor Angiogenesis
Cancer Res., September 1, 2004; 64(17): 6119 - 6126.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
U. Fiedler, M. Scharpfenecker, S. Koidl, A. Hegen, V. Grunow, J. M. Schmidt, W. Kriz, G. Thurston, and H. G. Augustin
The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
Blood, June 1, 2004; 103(11): 4150 - 4156.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Fan, O. Stoeltzing, W. Liu, M. F. McCarty, Y. D. Jung, N. Reinmuth, and L. M. Ellis
Interleukin-1{beta} Regulates Angiopoietin-1 Expression in Human Endothelial Cells
Cancer Res., May 1, 2004; 64(9): 3186 - 3190.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. Zadeh, B. Qian, A. Okhowat, N. Sabha, C. D. Kontos, and A. Guha
Targeting the Tie2/Tek Receptor in Astrocytomas
Am. J. Pathol., February 1, 2004; 164(2): 467 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
O. Stoeltzing, W. Liu, N. Reinmuth, F. Fan, A. A. Parikh, C. D. Bucana, D. B. Evans, G. L. Semenza, and L. M. Ellis
Regulation of Hypoxia-Inducible Factor-1{alpha}, Vascular Endothelial Growth Factor, and Angiogenesis by an Insulin-Like Growth Factor-I Receptor Autocrine Loop in Human Pancreatic Cancer
Am. J. Pathol., September 1, 2003; 163(3): 1001 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Hu, P. Guo, Q. Fang, H.-Q. Tao, D. Wang, M. Nagane, H.-J. Su Huang, Y. Gunji, R. Nishikawa, K. Alitalo, et al.
Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2
PNAS, July 22, 2003; 100(15): 8904 - 8909.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
O. Stoeltzing, S. A. Ahmad, W. Liu, M. F. McCarty, J. S. Wey, A. A. Parikh, F. Fan, N. Reinmuth, M. Kawaguchi, C. D. Bucana, et al.
Angiopoietin-1 Inhibits Vascular Permeability, Angiogenesis, and Growth of Hepatic Colon Cancer Tumors
Cancer Res., June 15, 2003; 63(12): 3370 - 3377.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, N. Yang, J.-W. Park, D. Katsaros, S. Fracchioli, G. Cao, A. O'Brien-Jenkins, T. C. Randall, S. C. Rubin, and G. Coukos
Tumor-derived Vascular Endothelial Growth Factor Up-Regulates Angiopoietin-2 in Host Endothelium and Destabilizes Host Vasculature, Supporting Angiogenesis in Ovarian Cancer
Cancer Res., June 15, 2003; 63(12): 3403 - 3412.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. R. White, S. Shan, C. P. Rusconi, G. Shetty, M. W. Dewhirst, C. D. Kontos, and B. A. Sullenger
Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2
PNAS, April 29, 2003; 100(9): 5028 - 5033.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Tanaka, S. Ishikawa, K. Yanagihara, R. Miyahara, Y. Kawano, M. Li, Y. Otake, and H. Wada
Expression of Angiopoietins and Its Clinical Significance in Non-Small Cell Lung Cancer
Cancer Res., December 1, 2002; 62(23): 7124 - 7129.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. J. Bernardi, C. S. Johnson, R. A. Modzelewski, and D. L. Trump
Antiproliferative Effects of 1{alpha},25-Dihydroxyvitamin D3 and Vitamin D Analogs on Tumor-Derived Endothelial Cells
Endocrinology, July 1, 2002; 143(7): 2508 - 2514.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. P. Taylor, L. Osorio, R. Craig, J. A. Raleigh, Z. Ying, D. M. Goldenberg, and R. D. Blumenthal
Tumor-specific Regulation of Angiogenic Growth Factors and Their Receptors during Recovery from Cytotoxic Therapy
Clin. Cancer Res., April 1, 2002; 8(4): 1213 - 1222.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Hawighorst, M. Skobe, M. Streit, Y.-K. Hong, P. Velasco, L. F. Brown, L. Riccardi, B. Lange-Asschenfeldt, and M. Detmar
Activation of the Tie2 Receptor by Angiopoietin-1 Enhances Tumor Vessel Maturation and Impairs Squamous Cell Carcinoma Growth
Am. J. Pathol., April 1, 2002; 160(4): 1381 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
Y. Mochizuki, T. Nakamura, H. Kanetake, and S. Kanda
Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn
J. Cell Sci., January 1, 2002; 115(1): 175 - 183.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.