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[Cancer Research 61, 1272-1275, February 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Hydroxamate-Type Matrix Metalloproteinase Inhibitor Batimastat Promotes Liver Metastasis1

Achim Krüger2, Rita Soeltl, Igor Sopov, Charlotte Kopitz, Matthias Arlt, Viktor Magdolen, Nadia Harbeck, Bernd Gänsbacher and Manfred Schmitt

Klinische Forschergruppe der Frauenklinik [A. K., R. S., I. S., V. M., N. H., M. S.], and Institut für Experimentelle Onkologie und Therapieforschung [A. K., C. K., M. A., B. G.], Technische Universität München, D-81675 Munich, Germany

Overexpression of matrix metalloproteinases (MMPs) facilitates tumor cell invasion. Synthetic MMP inhibitors such as batimastat have been designed to treat cancer. We report that because of batimastat treatment, human breast carcinoma cells metastasized to the liver in nude mice and that an increase of liver metastases of murine T-cell lymphoma cells was observed in syngeneic mice. Batimastat treatment also caused liverspecific overexpression of MMPs-2, -9, and mRNA up-regulation of angiogenesis factors and caspase-1, even in tumor-free animals. Induction of organ-specific side effects need to be taken into account regarding further development and clinical use of synthetic MMP inhibitors.




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Copyright © 2001 by the American Association for Cancer Research.