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[Cancer Research 61, 1296-1298, February 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Invasiveness of Cutaneous Malignant Melanoma Is Influenced by Matrix Metalloproteinase 1 Gene Polymorphism1

Shu Ye2, Sahar Dhillon, Steven J. Turner, Adrian C. Bateman, Jeffrey M. Theaker, Ruth M. Pickering, Ian Day and W. Martin Howell

Human Genetics Research Division [S. Y., S. D., S. J. T., I. D., W. M. H.] and Medical Statistics Group [R. M. P.], University of Southampton School of Medicine, and Department of Histopathology, Southampton University Hospitals NHS Trust [A. C. B., J. M. T.], Southampton, United Kingdom

The matrix metalloproteinases (MMPs) are implicated in connective tissue destruction during cancer invasion and metastasis. A naturally occurring variant arising from the insertion or deletion of a guanine in the promoter of the MMP-1 gene has recently been reported and shown to influence its transcriptional activity in melanoma cells. In this study, MMP-1 genotype was determined in 139 Caucasian patients with cutaneous malignant melanoma. The insertion allele was associated with deep invasive, and therefore poorer-prognosis, primary tumors [(34% of patients with vertical growth phase tumor were homozygous for the insertion allele compared with 17% of patients with horizontal growth phase tumor (P = 0.0333; odds ratio = 2.51)]. These data suggest that the invasiveness of cutaneous malignant melanoma is influenced by variation in the MMP-1 gene promoter that affects MMP-1 expression.




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