Cancer Research Meeting Calendar EMT and Cancer Progression and Treatment
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marks, D. L.
Right arrow Articles by Cone, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marks, D. L.
Right arrow Articles by Cone, R. D.
[Cancer Research 61, 1432-1438, February 15, 2001]
© 2001 American Association for Cancer Research

Endocrinology

Role of the Central Melanocortin System in Cachexia1

Daniel L. Marks, Nicholas Ling and Roger D. Cone2

Department of Pediatric Endocrinology [D. L. M.], Vollum Institute [R. D. C.], Oregon Health Sciences University, Portland, Oregon 97201, and Neurocrine Biosciences, Inc. [N. L.], San Diego, California

Individuals affected with either acute or chronic diseases often show disorders of nutrient balance. In some cases, a devastating state of malnutrition known as cachexia arises, brought about by a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass. Stimulation of the hypothalamic melanocortin 4 receptor (MC4-R) produces relative anorexia and increased metabolic rate, even in a relatively starved state. Here we demonstrate that cachexia induced by lipopolysaccharide administration and by tumor growth is ameliorated by central MC4-R blockade. MC4-R knock-out mice or mice administered the MC3-R/MC4-R antagonist, agouti-related peptide, resist tumor-induced loss of lean body mass, and maintain normal circadian activity patterns during tumor growth. The final tumor mass is not affected in these animals, providing further support for the potential role of MC4-R antagonism in the treatment of cachexia in disease states.




This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
M. J. Tisdale
Mechanisms of Cancer Cachexia
Physiol Rev, April 1, 2009; 89(2): 381 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Laviano, A. Inui, D. L. Marks, M. M. Meguid, C. Pichard, F. Rossi Fanelli, and M. Seelaender
Neural control of the anorexia-cachexia syndrome
Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1000 - E1008.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
J. L. Sartin, D. L. Marks, C. D. McMahon, J. A. Daniel, P. Levasseur, C. G. Wagner, B. K. Whitlock, and B. P. Steele
Central role of the melanocortin-4 receptors in appetite regulation after endotoxin
J Anim Sci, October 1, 2008; 86(10): 2557 - 2567.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L. D Madison, J. M Scarlett, P. Levasseur, X. Zhu, K. Newcomb, A. Batra, D. Bowe, and D. L Marks
Prostacyclin signaling regulates circulating ghrelin during acute inflammation
J. Endocrinol., February 1, 2008; 196(2): 263 - 273.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. D. DeBoer, X. Zhu, P. R. Levasseur, A. Inui, Z. Hu, G. Han, W. E. Mitch, J. E. Taylor, H. A. Halem, J. Z. Dong, et al.
Ghrelin Treatment of Chronic Kidney Disease: Improvements in Lean Body Mass and Cytokine Profile
Endocrinology, February 1, 2008; 149(2): 827 - 835.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. R. Ropelle, J. R. Pauli, K. G. Zecchin, M. Ueno, C. T. de Souza, J. Morari, M. C. Faria, L. A. Velloso, M. J. A. Saad, and J. B. C. Carvalheira
A Central Role for Neuronal Adenosine 5'-Monophosphate-Activated Protein Kinase in Cancer-Induced Anorexia
Endocrinology, November 1, 2007; 148(11): 5220 - 5229.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
W. W. Cheung, H.-J. Kuo, S. Markison, C. Chen, A. C. Foster, D. L. Marks, and R. H. Mak
Peripheral Administration of the Melanocortin-4 Receptor Antagonist NBI-12i Ameliorates Uremia-Associated Cachexia in Mice
J. Am. Soc. Nephrol., September 1, 2007; 18(9): 2517 - 2524.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. D. DeBoer, X. X. Zhu, P. Levasseur, M. M. Meguid, S. Suzuki, A. Inui, J. E. Taylor, H. A. Halem, J. Z. Dong, R. Datta, et al.
Ghrelin Treatment Causes Increased Food Intake and Retention of Lean Body Mass in a Rat Model of Cancer Cachexia
Endocrinology, June 1, 2007; 148(6): 3004 - 3012.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Hashimoto, Y. Azuma, M. Kawasaki, H. Fujihara, E. Onuma, H. Yamada-Okabe, Y. Takuwa, E. Ogata, and Y. Ueta
Parathyroid Hormone-Related Protein Induces Cachectic Syndromes without Directly Modulating the Expression of Hypothalamic Feeding-Regulating Peptides
Clin. Cancer Res., January 1, 2007; 13(1): 292 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. D. Cone
Studies on the Physiological Functions of the Melanocortin System
Endocr. Rev., December 1, 2006; 27(7): 736 - 749.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
K. L.J Ellacott and R. D Cone
The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models
Phil Trans R Soc B, July 29, 2006; 361(1471): 1265 - 1274.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. Perboni and A. Inui
Anorexia in cancer: role of feeding-regulatory peptides
Phil Trans R Soc B, July 29, 2006; 361(1471): 1281 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. R. Nicholson, G. Kohler, F. Schaerer, C. Senn, P. Weyermann, and K. G. Hofbauer
Peripheral Administration of a Melanocortin 4-Receptor Inverse Agonist Prevents Loss of Lean Body Mass in Tumor-Bearing Mice
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 771 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Palliat MedHome page
A. Wilcock
Anorexia: a taste of things to come?
Palliative Medicine, January 1, 2006; 20(1): 43 - 45.
[PDF]

Home page
 Nephrol Dial TransplantHome page
A. Wi""cek
How does leptin contribute to uraemic cachexia?
Nephrol. Dial. Transplant., December 1, 2005; 20(12): 2620 - 2622.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. W, Y. PX, L. BM, C. RD, M. DL, M. RH, I. H, O. MH, W. K, B.-J. K, et al.
Anorexia and Cachexia in Renal Failure--Is Leptin the Culprit?: Role of Leptin and Melanocortin Signaling in Uremia-Associated Cachexia. J Clin Invest 115: 1659-1665, 2005
J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2245 - 2250.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Markison, A. C. Foster, C. Chen, G. B. Brookhart, A. Hesse, S. R. J. Hoare, B. A. Fleck, B. T. Brown, and D. L. Marks
The Regulation of Feeding and Metabolic Rate and the Prevention of Murine Cancer Cachexia with a Small-Molecule Melanocortin-4 Receptor Antagonist
Endocrinology, June 1, 2005; 146(6): 2766 - 2773.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Deshmukh, B. G. Phillips, T. O'Dorisio, M. J. Flanigan, and V. S. Lim
Hormonal responses to fasting and refeeding in chronic renal failure patients
Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E47 - E55.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
G. Mantovani, C. Madeddu, A. Maccio, G. Gramignano, M. R. Lusso, E. Massa, G. Astara, and R. Serpe
Cancer-Related Anorexia/Cachexia Syndrome and Oxidative Stress: An Innovative Approach beyond Current Treatment
Cancer Epidemiol. Biomarkers Prev., October 1, 2004; 13(10): 1651 - 1659.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. F. Kelly, C. F. Elias, C. E. Lee, R. S. Ahima, R. J. Seeley, C. Bjorbaek, T. Oka, C. B. Saper, J. S. Flier, and J. K. Elmquist
Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain
Diabetes, April 1, 2004; 53(4): 911 - 920.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Matsuki, R. Horai, K. Sudo, and Y. Iwakura
IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological Conditions
J. Exp. Med., September 15, 2003; 198(6): 877 - 888.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. M. Zigman and J. K. Elmquist
Minireview: From Anorexia to Obesity--The Yin and Yang of Body Weight Control
Endocrinology, September 1, 2003; 144(9): 3749 - 3756.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. L. Marks, A. A. Butler, R. Turner, G. Brookhart, and R. D. Cone
Differential Role of Melanocortin Receptor Subtypes in Cachexia
Endocrinology, April 1, 2003; 144(4): 1513 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
D. Hamerman
Molecular-Based Therapeutic Approaches in Treatment of Anorexia of Aging and Cancer Cachexia
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2002; 57(8): M511 - 518.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. M. Reyes and P. E. Sawchenko
Involvement of the Arcuate Nucleus of the Hypothalamus in Interleukin-1-Induced Anorexia
J. Neurosci., June 15, 2002; 22(12): 5091 - 5099.
[Abstract] [Full Text] [PDF]

Home page
 CA Cancer J ClinHome page
A. Inui
Cancer Anorexia-Cachexia Syndrome: Current Issues in Research and Management
CA Cancer J Clin, March 1, 2002; 52(2): 72 - 91.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. M. Lechan and J. B. Tatro
Editorial: Hypothalamic Melanocortin Signaling in Cachexia
Endocrinology, August 1, 2001; 142(8): 3288 - 3291.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
B. E. Wisse, R. S. Frayo, M. W. Schwartz, and D. E. Cummings
Reversal of Cancer Anorexia by Blockade of Central Melanocortin Receptors in Rats
Endocrinology, August 1, 2001; 142(8): 3292 - 3301.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.