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[Cancer Research 61, 1833-1838, March 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Invasion-specific Genes in Malignancy

Serial Analysis of Gene Expression Comparisons of Primary and Passaged Cancers1

Byungwoo Ryu, Jessa Jones, Michael A. Hollingsworth, Ralph H. Hruban and Scott E. Kern2

Departments of Oncology [B. R., J. J., S. E. K.] and Pathology [R. H. H., S. E. K.], The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, and The Eppley Institute, The University of Nebraska Medical Center, Omaha, Nebraska 68198 [M. A. H.]

The invasive growth of malignant cells induces an admixture of host reactions including desmoplasia, angiogenesis, and immune reactions. Pancreatic cancer has a prominent and characteristic host reaction at the site of primary invasion. To obtain new insights into the process of tumor invasion, we studied global patterns of gene expression using serial analysis of gene expression in pancreatic cancer, with extension to other tumor types. Here we report a cluster of invasion-specific genes in pancreatic and other cancers. This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Copyright © 2001 by the American Association for Cancer Research.