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[Cancer Research 61, 1839-1842, March 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Aberrant Expression of HDMX Proteins in Tumor Cells Correlates with Wild-Type p53

Yolande F. M. Ramos, Robert Stad, Joline Attema, Lucy T. C. Peltenburg, Alex J. van der Eb and Aart G. Jochemsen1

Department of Molecular Cell Biology and Center of Biomedical Genetics [Y. F. M. R., R. S., J. A., A. J. v. d. E., A. G. J.] and Department of Clinical Oncology [L. T. C. P.], Leiden University Medical Center, 2333 AL Leiden, the Netherlands

It has been shown that the Hdmx gene is amplified in a subset of gliomas, but thus far, no data are available on HDMX protein expression in tumor cells. We now report that a significant fraction of tumor cell lines expresses increased HDMX levels compared with normal cells; in general, HDMX expression in these tumor cell lines correlates with the presence of wild-type p53. Analysis of tumor material showed that high HDMX expression is not a result of cell line establishment. Interestingly, several cell lines express alternative, shorter HDMX proteins. These results suggest that deregulated expression of HDMX plays a role in carcinogenesis as an alternative way to inactivate p53.




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Cancer Research Clinical Cancer Research
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Molecular Cancer Research Cancer Prevention Research
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Copyright © 2001 by the American Association for Cancer Research.