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[Cancer Research 61, 2129-2137, March 1, 2001]
© 2001 American Association for Cancer Research

Molecular Biology and Genetics

Genome-wide Analysis of Gene Expression in Human Hepatocellular Carcinomas Using cDNA Microarray

Identification of Genes Involved in Viral Carcinogenesis and Tumor Progression1

Hiroshi Okabe, Seiji Satoh, Tatsushi Kato, Osamu Kitahara, Renpei Yanagawa, Yoshio Yamaoka, Tatsuhiko Tsunoda, Yoichi Furukawa and Yusuke Nakamura2

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639 [H. O., S. S., T. K., O. K., R. Y., Y. F., Y. N.], Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507 [H. O., T. K., Y. Y.], and Laboratory for Medical Informatics, SNP Research Center, Riken (Institute of Physical and Chemical Research), Tokyo 108-8639 [T. T.], Japan

To disclose detailed genetic mechanisms in hepatocellular carcinoma (HCC) with a view toward development of novel therapeutic targets, we analyzed expression profiles of 20 primary HCCs and their corresponding noncancerous tissues by means of cDNA microarrays consisting of 23,040 genes. Up-regulation of mitosis-promoting genes was observed in the majority of the tumors examined. Some genes showed expression patterns in hepatitis B virus-positive HCCs that were different from those in hepatitis C virus-positive HCCs; most of them encoded enzymes that metabolize carcinogens and/or anticancer agents. Furthermore, we identified a number of genes associated with malignant histological type or invasive phenotype. Accumulation of such data will make it possible to define the nature of individual tumors, to provide clues for identifying new therapeutic targets, and ultimately to optimize treatment of each patient.




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