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[Cancer Research 61, 2361-2364, March 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Invasion Activating Caveolin-1 Mutation in Human Scirrhous Breast Cancers1

Kazuhiko Hayashi2, Satoru Matsuda2,, 3, Kazuya Machida, Tatsuyoshi Yamamoto, Yoshihide Fukuda, Yuji Nimura, Tetsuo Hayakawa and Michinari Hamaguchi

Department of Molecular Pathogenesis [K. H., S. M., K. M., M. H.], Second Department of Internal Medicine [K. H., K. M., Y. F., T. H.], and First Department of Surgery [T. Y., Y. N.], Nagoya University School of Medicine, Nagoya 466-8550 Japan

We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer.




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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
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Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.