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[Cancer Research 61, 2390-2394, March 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Activated in Prostate Cancer

A PDZ Domain-containing Protein Highly Expressed in Human Primary Prostate Tumors1

Hassan Chaib, Mark A. Rubin, Neil R. Mucci, Lang Li, Jeremy M. G. Taylor, Mark L. Day, Johng S. Rhim and Jill A. Macoska2

The Departments of Surgery, Section of Urology [H. C., M. A. R., M. L. D., J. A. M.], Pathology [M. A. R., N. R. M.], and Biostatistics [L. L., J. M. G. T.], and the Comprehensive Cancer Center [M. A. R., J. M. G. T., M. L. D., J. A. M.], The University of Michigan, Ann Arbor, Michigan 48109-0946, and The Center for Prostate Disease Research, The Uniformed Services University of the Health Sciences, Rockville, Maryland 20852 [J. S. R.]

Critical events in prostate tumorigenesis and metastasis likely include the abnormal activation and expression of specific genes. Using RNA expression profiling techniques, we have identified a transcript originating from the activated in prostate cancer (AIPC) gene, the expression of which is preferentially up-regulated in several cultured prostate tumor cell lines and human primary prostate tumors. Sequence analysis revealed that the AIPC protein encodes six PDZ domains, which are protein-protein binding domains likely involved in protein clustering and scaffolding. Immunohistochemical analysis of a tissue microarray comprising 158 tumor, 18 high-grade prostatic intraepithelial neoplasia, and 91 normal prostate specimens with an anti-AIPC antibody demonstrated abundant AIPC protein expression in 75% of tumors, 83% of prostatic intraepithelial neoplasia lesions, and 3% of normal tissues (P < 0.0001). These data suggest that the accumulation of AIPC protein may be closely associated with the initiation or early promotion of prostate tumorigenesis.




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