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[Cancer Research 61, 2395-2398, March 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Intestinal Microflora Are Necessary for Development of Spontaneous Adenocarcinoma of the Large Intestine in T-Cell Receptor ß Chain and p53 Double-Knockout Mice

Shoichi Kado1, Kazumi Uchida, Hideyuki Funabashi, Shin Iwata, Yuriko Nagata, Minoru Ando, Masaharu Onoue, Yoshiaki Matsuoka, Makoto Ohwaki and Masami Morotomi

Yakult Central Institute for Microbiological Research, Kunitachi-shi, Tokyo, 186-8650, Japan

This study was conducted to confirm the hypothesis that intestinal microflora are required for the development of adenocarcinoma in the colon of the TCRß and p53 double-knockout (TCRß-/- p53-/-) mouse. Germ-free TCRß-/- p53-/- mice were produced. At 7 weeks of age, the animals were divided into two groups (n = 10/group), and one of these groups was conventionalized. Animals of both groups were subjected to histopathological examination for adenocarcinoma of the colon at 4 months of age. There was no development of adenocarcinoma of the colon among the germ-free mice, whereas in the conventionalized group, adenocarcinomas of the ileocecum and cecum were detected in 70% of animals. These results indicate the usefulness of the TCRß-/- p53-/- mouse as a colon cancer animal model that develops spontaneous adenocarcinoma of the colon early in life, and suggest that intestinal microflora play a major role in the development of adenocarcinoma of the colon in this animal model.




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Copyright © 2001 by the American Association for Cancer Research.