Cancer Research AACR Legacy Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Masur, K.
Right arrow Articles by Entschladen, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Masur, K.
Right arrow Articles by Entschladen, F.
[Cancer Research 61, 2866-2869, April 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Norepinephrine-induced Migration of SW 480 Colon Carcinoma Cells Is Inhibited by ß-Blockers1

Kai Masur2, Bernd Niggemann, Kurt S. Zanker and Frank Entschladen

Institute for Immunology, Witten/Herdecke University, 58448 Witten, Germany

ß-Adrenoceptors are highly expressed on SW 480 colon carcinoma cells as was assessed by flow cytometry. We investigated the influence of norepinephrine on the migration of these cells using time-lapse videomicroscopy. Norepinephrine-treatment increased the locomotor activity within the population from 25% spontaneously locomoting cells to 65% locomoting cells. The ß1/2-blocker propranolol but not the ß1-blocker atenolol inhibited this increase. The intracellular signaling solely of norepinephrine-induced locomotion involved protein tyrosine kinase activity, whereas both spontaneous and norepinephrine-induced migration were reduced by inhibiting phospholipase C{gamma} and protein kinase C{alpha} activity. In summary, norepinephrine-induced locomotion of SW 480 cells is ß2-adrenoceptor mediated and distinct from spontaneous locomotion concerning the PTK involvement.




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
H. A. N. Al-Wadei, H. K. Plummer III, and H. M. Schuller
Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter {gamma}-aminobutyric acid
Carcinogenesis, March 1, 2009; 30(3): 506 - 511.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. M. Schuller, H. A.N. Al-Wadei, and M. Majidi
Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma
Carcinogenesis, October 1, 2008; 29(10): 1979 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
X. Liu, W. K. K. Wu, L. Yu, Z. J. Li, J. J. Y. Sung, S. T. Zhang, and C. H. Cho
Epidermal Growth Factor-Induced Esophageal Cancer Cell Proliferation Requires Transactivation of {beta}-Adrenoceptors
J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 69 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
P. Bastian, B. Posch, K. Lang, B. Niggemann, K. S. Zaenker, H. Hatt, and F. Entschladen
Phosphatidylinositol 3-Kinase in the G Protein-Coupled Receptor-Induced Chemokinesis and Chemotaxis of MDA-MB-468 Breast Carcinoma Cells: A Comparison with Leukocytes
Mol. Cancer Res., June 1, 2006; 4(6): 411 - 421.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. E. Pullar and R. R. Isseroff
The {beta}2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms
J. Cell Sci., February 1, 2006; 119(3): 592 - 602.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. K. Sood, R. Bhatty, A. A. Kamat, C. N. Landen, L. Han, P. H. Thaker, Y. Li, D. M. Gershenson, S. Lutgendorf, and S. W. Cole
Stress Hormone-Mediated Invasion of Ovarian Cancer Cells
Clin. Cancer Res., January 15, 2006; 12(2): 369 - 375.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. K.K. Wu, H. P.S. Wong, S. W. Luo, K. Chan, F. Y. Huang, M. K.C. Hui, E. K.Y. Lam, V. Y. Shin, Y. N. Ye, Y. H. Yang, et al.
4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via {beta}-Adrenoceptors
Cancer Res., June 15, 2005; 65(12): 5272 - 5277.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. E. Pullar, J. Chen, and R. R. Isseroff
PP2A Activation by {beta}2-Adrenergic Receptor Agonists: NOVEL REGULATORY MECHANISM OF KERATINOCYTE MIGRATION
J. Biol. Chem., June 13, 2003; 278(25): 22555 - 22562.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Joseph, B. Niggemann, K. S. Zaenker, and F. Entschladen
The Neurotransmitter {gamma}-Aminobutyric Acid Is an Inhibitory Regulator for the Migration of SW 480 Colon Carcinoma Cells
Cancer Res., November 15, 2002; 62(22): 6467 - 6469.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.