Cancer Research Cancer Research Funding Available Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ferrarini, M.
Right arrow Articles by Manfredi, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferrarini, M.
Right arrow Articles by Manfredi, A. A.
[Cancer Research 61, 3092-3095, April 1, 2001]
© 2001 American Association for Cancer Research

Immunology

Inhibition of Caspases Maintains the Antineoplastic Function of {gamma}{delta} T Cells Repeatedly Challenged with Lymphoma Cells1

Marina Ferrarini2, Giuseppe Consogno, Patrizia Rovere, Clara Sciorati, Lorenzo Dagna, Davide Resta, Claudio Rugarli and Angelo A. Manfredi

Laboratory of Tumor Immunology and Cancer Immunotherapy and Gene Therapy Program, Department of Medicine [M. F., G. C., P. R., L. D., D. R., C. R., A. A. M.], and Department of Neuroscience [C. S.], Hospital San Raffaele Scientific Institute, 20132 Milano, Italy, and Vita-Salute San Raffaele University, 20132 Milano, Italy [C. R.]

T lymphocytes recognizing tumor antigens eventually undergo anergy or Fas-mediated death. V{gamma}9/V{delta}2+ T cells recognize poorly characterized ligand moieties on human B-cell lymphomas. Here we show that {gamma}{delta} T cells, a model for the study of activation-induced apoptosis, activate on repeated in vitro antigen-recognition caspase 3 and 8 and dramatically down-regulate their cytotoxic and secretory function. Caspase hindrance enhanced {gamma}{delta} T cell survival and sustained the killing of neoplastic cells and the release of IFN-{gamma} and tumor necrosis factor {alpha}. Caspases of tumor-specific T cells represent a candidate target to complement adoptive immunotherapy strategies.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. Poggi, A.-M. Massaro, S. Negrini, P. Contini, and M. R. Zocchi
Tumor-Induced Apoptosis of Human IL-2-Activated NK Cells: Role of Natural Cytotoxicity Receptors
J. Immunol., March 1, 2005; 174(5): 2653 - 2660.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
D. Santini, U. Vespasiani Gentilucci, B. Vincenzi, A. Picardi, F. Vasaturo, A. La Cesa, N. Onori, S. Scarpa, and G. Tonini
The antineoplastic role of bisphosphonates: from basic research to clinical evidence
Ann. Onc., October 1, 2003; 14(10): 1468 - 1476.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.