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Angiogenic Activity of Pyruvic Acid in in Vivo and in Vitro Angiogenesis Models¹

Department of Molecular Biology, Pusan National University, Pusan 609-735 [M-S. L., E-J. M., S-W. L., M. S. K., Y-J. K.] and College of Pharmacy, Seoul National University, Seoul 151-742 [K-W. K.], Korea

The excessive growth of a tumor requires high rates of glucose uptake and glycolysis and continuous recruitment of new blood vessels. Here, we provide several lines of evidence showing that pyruvic acid, the end product of glycolysis, exhibits strong angiogenic activity. Pyruvic acid promoted angiogenesis in chorioallantoic membrane assay and in vivo mouse Matrigel plug assay. Pyruvic acid also positively affects angiogenic cascade, DNA synthesis, migration, and tube formation in bovine aortic endothelial cells. Furthermore, mRNA expression of fibroblast growth factor receptor-2 and vascular endothelial growth factor was enhanced by pyruvic acid. These results strongly suggest that pyruvic acid plays an important role in angiogenesis for tumor growth and metastasis.

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