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[Cancer Research 61, 3321-3325, April 15, 2001]
© 2001 American Association for Cancer Research

Epidemiology and Prevention

An Intronic Poly (AT) Polymorphism of the DNA Repair Gene XPC and Risk of Squamous Cell Carcinoma of the Head and Neck

A Case-Control Study1

Hongbing Shen, Erich M. Sturgis, Sikandar G. Khan, Yawei Qiao, Tala Shahlavi, Susan A. Eicher, Yiaochu Xu, Xinru Wang, Sara S. Strom, Margaret R. Spitz, Kenneth H. Kraemer and Qingyi Wei2

Departments of Epidemiology [H. S., E. M. S., Y. Q., S. S. S., M. R. S., Q. W.] and Head and Neck Surgery [E. M. S., S. A. E.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Department of Epidemiology and Statistics [H. S., Y. X., X. W.], School of Public Health, Nanjing Medical University, Nanjing, 210029 The People’s Republic of China; and Basic Research Laboratory [S. G. K., T. S., K. H. K.], National Cancer Institute, Bethesda, Maryland 20892

Inherited polymorphisms of DNA repair genes may contribute to variations in DNA repair capacity and genetic susceptibility to cancer. In a hospital-based case-control study of 287 non-Hispanic white patients with newly diagnosed SCCHN and 311 control subjects matched on age, sex, ethnicity, and smoking status, we investigated the role of a newly identified variant allele of XPC, XPC-PAT+. We found that the frequency of the XPC-PAT+ allele was higher in the cases (0.409) than in the controls (0.333; P = 0.007). Fifty cases (17.4%) and 37 controls (11.9%) were XPC-PAT+/+, and 135 (47.0%) cases and 133 controls (42.8%) were XPC-PAT+/-. XPC-PAT+/- and XPC-PAT+/+ subjects were at significantly increased risk for SCCHN [adjusted odds ratios = 1.44 and 1.85, respectively (95% confidence intervals, 1.01–2.05 and 1.12–3.05, respectively; trend test, P = 0.007)]. We did not find ethnic difference in the frequency of XPC-PAT+ allele among four groups aged between 19 and 75 years: non-Hispanic whites, 294; African-Americans, 178; Hispanic-Americans, 103; and native Chinese, 119 (0.333, 0.281, 0.296, and 0.353, respectively). The case-control findings support the hypothesis that the XPC-PAT+ allele may contribute to the risk of developing SCCHN.




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Copyright © 2001 by the American Association for Cancer Research.