Cancer Research Cell Death Mechanisms and Cancer Therapy Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Issa, J.-P. J.
Right arrow Articles by Brentnall, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Issa, J.-P. J.
Right arrow Articles by Brentnall, T. A.
[Cancer Research 61, 3573-3577, May 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Accelerated Age-related CpG Island Methylation in Ulcerative Colitis1

Jean-Pierre J. Issa2, Nita Ahuja, Minoru Toyota, Mary P. Bronner and Teresa A. Brentnall

University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 [J-P. J. I.]; Johns Hopkins Oncology Center, Baltimore, Maryland 21231 [J-P. J. I., N. A., M. T.]; and University of Washington, Seattle, Washington 98195 [M. P. B., T. A. B.]

CpG island hypermethylation is a mechanism of gene silencing that can be usurped by neoplastic cells to inactivate undesirable genes. In the colon, hypermethylation often starts in normal mucosa as a function of age and is markedly increased in cancer. To test the hypothesis that subjects at increased risk of colon cancer have higher levels of methylation in their nonneoplastic mucosa, we studied methylation patterns of five genes in the normal and dysplastic mucosa of patients with ulcerative colitis (UC), a condition associated with a marked increased risk of colon cancer. One gene (Mlh1) was unmethylated in all tissues examined. All four remaining genes had low but detectable levels of methylation in the epithelium of UC patients without evidence of dysplasia, and this methylation was not different from non-UC controls. By contrast, all four genes were highly methylated in dysplastic epithelium from high-grade dysplasia (HGD)/cancer patients with UC; methylation in HGD versus controls averaged 40.0% versus 7.4% (P = 0.00003) for ER, 44.0% versus 3.0% (P < 0.00003) for MYOD, 9.4% versus 2.4% (P = 0.03) for p16 exon 1, and 57.5% versus 30.6% (P = 0.01) for CSPG2. Importantly, three of the four genes were also highly methylated in the normal appearing (nondysplastic) epithelium from these same HGD/cancer patients, indicating that methylation precedes dysplasia and is widespread in these patients. Compared with controls, methylation averaged 20.1% versus 7.2% (P = 0.07) for ER, 18.4% versus 3.0% (P < 0.008) for MYOD, and 7.9% versus 2.4% (P = 0.007) for p16 exon 1. These results are consistent with the hypothesis that age-related methylation marks (and may lead to) the field defect that reflects acquired predisposition to colorectal neoplasia. Furthermore, the data suggest that chronic inflammation is associated with high levels of methylation, perhaps as a result of increased cell turnover, and that UC can be viewed as resulting in premature aging of colorectal epithelial cells.




This article has been cited by other articles:


Home page
 Genome ResHome page
H. Takeshima, S. Yamashita, T. Shimazu, T. Niwa, and T. Ushijima
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands
Genome Res., November 1, 2009; 19(11): 1974 - 1982.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S.-W. Guo
Epigenetics of endometriosis
Mol. Hum. Reprod., October 1, 2009; 15(10): 587 - 607.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. B. Lee, E. J. Lee, E. H. Jung, H.-K. Chun, D. K. Chang, S. Y. Song, J. Park, and D.-H. Kim
Aberrant Methylation of APC, MGMT, RASSF2A, and Wif-1 Genes in Plasma as a Biomarker for Early Detection of Colorectal Cancer
Clin. Cancer Res., October 1, 2009; 15(19): 6185 - 6191.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Prevention ResearchHome page
Concordant DNA Methylation in Synchronous Colorectal Carcinomas
Cancer Prevention Research, September 1, 2009; 2(9): 814 - 822.


Home page
 JNCI J Natl Cancer InstHome page
V. Melotte, M. H. F. M. Lentjes, S. M. van den Bosch, D. M. E. I. Hellebrekers, J. P. J. de Hoon, K. A. D. Wouters, K. L. J. Daenen, I. E. J. M. Partouns-Hendriks, F. Stessels, J. Louwagie, et al.
N-Myc Downstream-Regulated Gene 4 (NDRG4): A Candidate Tumor Suppressor Gene and Potential Biomarker for Colorectal Cancer
J Natl Cancer Inst, July 1, 2009; 101(13): 916 - 927.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
T. TAHARA, T. SHIBATA, T. ARISAWA, M. NAKAMURA, H. YAMASHITA, D. YOSHIOKA, M. OKUBO, N. MARUYAMA, T. KAMANO, Y. KAMIYA, et al.
Impact of Catechol-O-methyltransferase (COMT) Gene Polymorphism on Promoter Methylation Status in Gastric Mucosa
Anticancer Res, July 1, 2009; 29(7): 2857 - 2861.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. M.E.I. Hellebrekers, M. H.F.M. Lentjes, S. M. van den Bosch, V. Melotte, K. A.D. Wouters, K. L.J. Daenen, K. M. Smits, Y. Akiyama, Y. Yuasa, S. Sanduleanu, et al.
GATA4 and GATA5 are Potential Tumor Suppressors and Biomarkers in Colorectal Cancer
Clin. Cancer Res., June 15, 2009; 15(12): 3990 - 3997.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
M. S. Ally, R. Al-Ghnaniem, and M. Pufulete
The Relationship between Gene-Specific DNA Methylation in Leukocytes and Normal Colorectal Mucosa in Subjects with and without Colorectal Tumors
Cancer Epidemiol. Biomarkers Prev., March 1, 2009; 18(3): 922 - 928.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. C. Christensen, E.A. Houseman, J. J. Godleski, C. J. Marsit, J. L. Longacker, C. R. Roelofs, M. R. Karagas, M. R. Wrensch, R.-F. Yeh, H. H. Nelson, et al.
Epigenetic Profiles Distinguish Pleural Mesothelioma from Normal Pleura and Predict Lung Asbestos Burden and Clinical Outcome
Cancer Res., January 1, 2009; 69(1): 227 - 234.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
D F Peng, M Razvi, H Chen, K Washington, A Roessner, R Schneider-Stock, and W El-Rifai
DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma
Gut, January 1, 2009; 58(1): 5 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. A. Hahn, T. Hahn, D.-H. Lee, R. S. Esworthy, B.-w. Kim, A. D. Riggs, F.-F. Chu, and G. P. Pfeifer
Methylation of Polycomb Target Genes in Intestinal Cancer Is Mediated by Inflammation
Cancer Res., December 15, 2008; 68(24): 10280 - 10289.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Yan, G. Dalmasso, H. T. T. Nguyen, T. S. Obertone, L. Charrier-Hisamuddin, S. V. Sitaraman, and D. Merlin
Nuclear Factor-{kappa}B Is a Critical Mediator of Ste20-Like Proline-/Alanine-Rich Kinase Regulation in Intestinal Inflammation
Am. J. Pathol., October 1, 2008; 173(4): 1013 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Prevention ResearchHome page
J.-P. Issa
Cancer Prevention: Epigenetics Steps Up to the Plate
Cancer Prevention Research, September 1, 2008; 1(4): 219 - 222.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Kukitsu, T. Takayama, K. Miyanishi, A. Nobuoka, S. Katsuki, Y. Sato, R. Takimoto, T. Matsunaga, J. Kato, T. Sonoda, et al.
Aberrant Crypt Foci as Precursors of the Dysplasia-Carcinoma Sequence in Patients with Ulcerative Colitis
Clin. Cancer Res., January 1, 2008; 14(1): 48 - 54.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Shen, M. Toyota, Y. Kondo, E Lin, L. Zhang, Y. Guo, N. S. Hernandez, X. Chen, S. Ahmed, K. Konishi, et al.
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
PNAS, November 20, 2007; 104(47): 18654 - 18659.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
F. L. Martin
Epigenomics and disease, 10th anniversary winter meeting of the UK Molecular Epidemiology Group (MEG), The Royal Statistical Society, London, UK, 8th December 2006
Mutagenesis, November 1, 2007; 22(6): 425 - 427.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. Al-Ghnaniem, J. Peters, R. Foresti, N. Heaton, and M. Pufulete
Methylation of estrogen receptor {alpha} and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia
Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1064 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
R. Cortese, F. Eckhardt, M. Volleth, M. Wehnert, U. Koelsch, P. Wieacker, and T. Brune
The retinol acid receptor B gene is hypermethylated in patients with familial partial lipodystrophy
J. Mol. Endocrinol., June 1, 2007; 38(6): 663 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Kagan, S. Srivastava, P. E. Barker, S. A. Belinsky, and P. Cairns
Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools
Cancer Res., May 15, 2007; 67(10): 4545 - 4549.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
J.J. Kim, H.S. Taylor, Z. Lu, O. Ladhani, J.M. Hastings, K.S. Jackson, Y. Wu, S.W. Guo, and A.T. Fazleabas
Altered expression of HOXA10 in endometriosis: potential role in decidualization
Mol. Hum. Reprod., May 1, 2007; 13(5): 323 - 332.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
Z. Herceg
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors
Mutagenesis, March 1, 2007; 22(2): 91 - 103.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Watanabe, T. Kobunai, E. Toda, T. Kanazawa, Y. Kazama, J. Tanaka, T. Tanaka, Y. Yamamoto, K. Hata, T. Kojima, et al.
Gene Expression Signature and the Prediction of Ulcerative Colitis-Associated Colorectal Cancer by DNA Microarray
Clin. Cancer Res., January 15, 2007; 13(2): 415 - 420.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Mihara, Y. Yoshida, T. Tsukamoto, K.-i. Inada, Y. Nakanishi, Y. Yagi, K. Imai, T. Sugimura, M. Tatematsu, and T. Ushijima
Methylation of Multiple Genes in Gastric Glands with Intestinal Metaplasia: A Disorder with Polyclonal Origins
Am. J. Pathol., November 1, 2006; 169(5): 1643 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P Minoo, K Baker, R Goswami, G Chong, W D Foulkes, A R Ruszkiewicz, M Barker, D Buchanan, J Young, and J R Jass
Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis
Gut, October 1, 2006; 55(10): 1467 - 1474.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A O O Chan, J Z Peng, S K Lam, K C Lai, M F Yuen, H K L Cheung, Y L Kwong, A Rashid, C K Chan, and B C-Y Wong
Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation
Gut, April 1, 2006; 55(4): 463 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Katoh, T. Shibata, A. Kokubu, H. Ojima, M. Fukayama, Y. Kanai, and S. Hirohashi
Epigenetic Instability and Chromosomal Instability in Hepatocellular Carcinoma
Am. J. Pathol., April 1, 2006; 168(4): 1375 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Maekita, K. Nakazawa, M. Mihara, T. Nakajima, K. Yanaoka, M. Iguchi, K. Arii, A. Kaneda, T. Tsukamoto, M. Tatematsu, et al.
High Levels of Aberrant DNA Methylation in Helicobacter pylori-Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
Clin. Cancer Res., February 1, 2006; 12(3): 989 - 995.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Weichart, J. Gobom, S. Klopfleisch, R. Hasler, N. Gustavsson, S. Billmann, H. Lehrach, D. Seegert, S. Schreiber, and P. Rosenstiel
Analysis of NOD2-mediated Proteome Response to Muramyl Dipeptide in HEK293 Cells
J. Biol. Chem., January 27, 2006; 281(4): 2380 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Matsubayashi, M. Canto, N. Sato, A. Klein, T. Abe, K. Yamashita, C. J. Yeo, A. Kalloo, R. Hruban, and M. Goggins
DNA Methylation Alterations in the Pancreatic Juice of Patients with Suspected Pancreatic Disease
Cancer Res., January 15, 2006; 66(2): 1208 - 1217.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Prokhortchouk, O. Sansom, J. Selfridge, I. M. Caballero, S. Salozhin, D. Aithozhina, L. Cerchietti, F. G. Meng, L. H. Augenlicht, J. M. Mariadason, et al.
Kaiso-Deficient Mice Show Resistance to Intestinal Cancer
Mol. Cell. Biol., January 1, 2006; 26(1): 199 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Tominaga, S. Fujii, K. Mukawa, M. Fujita, K. Ichikawa, S. Tomita, Y. Imai, K. Kanke, Y. Ono, A. Terano, et al.
Prediction of Colorectal Neoplasia by Quantitative Methylation Analysis of Estrogen Receptor Gene in Nonneoplastic Epithelium from Patients with Ulcerative Colitis
Clin. Cancer Res., December 15, 2005; 11(24): 8880 - 8885.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. O. Chan, A. S. Soliman, Q. Zhang, A. Rashid, A. Bedeir, P. S. Houlihan, N. Mokhtar, N. Al-Masri, U. Ozbek, R. Yaghan, et al.
Differing DNA Methylation Patterns and Gene Mutation Frequencies in Colorectal Carcinomas from Middle Eastern Countries
Clin. Cancer Res., December 1, 2005; 11(23): 8281 - 8287.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
E. Giovannucci and S. Ogino
DNA Methylation, Field Effects, and Colorectal Cancer
J Natl Cancer Inst, September 21, 2005; 97(18): 1317 - 1319.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. Shen, Y. Kondo, G. L. Rosner, L. Xiao, N. S. Hernandez, J. Vilaythong, P. S. Houlihan, R. S. Krouse, A. R. Prasad, J. G. Einspahr, et al.
MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer
J Natl Cancer Inst, September 21, 2005; 97(18): 1330 - 1338.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S Fujii, K Tominaga, K Kitajima, J Takeda, T Kusaka, M Fujita, K Ichikawa, S Tomita, Y Ohkura, Y Ono, et al.
Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis
Gut, September 1, 2005; 54(9): 1287 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. W. Laird
Cancer epigenetics
Hum. Mol. Genet., April 15, 2005; 14(suppl_1): R65 - R76.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Matsubayashi, N. Sato, K. Brune, A. L. Blackford, R. H. Hruban, M. Canto, C. J. Yeo, and M. Goggins
Age- and Disease-Related Methylation of Multiple Genes in Nonneoplastic Duodenum and in Duodenal Juice
Clin. Cancer Res., January 15, 2005; 11(2): 573 - 583.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. A. Pereira, L. Tao, W. Wang, Y. Li, A. Umar, V. E. Steele, and R. A. Lubet
Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-{alpha} gene in rat colon tumors
Carcinogenesis, October 1, 2004; 25(10): 1917 - 1923.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
N. J. Belshaw, G. O. Elliott, E. A. Williams, D. M. Bradburn, S. J. Mills, J. C. Mathers, and I. T. Johnson
Use of DNA from Human Stools to Detect Aberrant CpG Island Methylation of Genes Implicated in Colorectal Cancer
Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1495 - 1501.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. H. Itzkowitz and X. Yio
Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G7 - G17.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Gifford, J. Paul, P. A. Vasey, S. B. Kaye, and R. Brown
The Acquisition of hMLH1 Methylation in Plasma DNA after Chemotherapy Predicts Poor Survival for Ovarian Cancer Patients
Clin. Cancer Res., July 1, 2004; 10(13): 4420 - 4426.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. Kim, Y. M. Kwon, J. S. Kim, H. Lee, J.-H. Park, Y. M. Shim, J. Han, J. Park, and D.-H. Kim
Tumor-Specific Methylation in Bronchial Lavage for the Early Detection of Non-Small-Cell Lung Cancer
J. Clin. Oncol., June 15, 2004; 22(12): 2363 - 2370.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. Kopelovich, J. A. Crowell, and J. R. Fay
The Epigenome as a Target for Cancer Chemoprevention
J Natl Cancer Inst, December 3, 2003; 95(23): 1747 - 1757.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Wang, M. Z. Fang, J. Liao, G.-Y. Yang, Y. Nie, Y. Song, C. So, X. Xu, L.-D. Wang, and C. S. Yang
Hypermethylation-Associated Inactivation of Retinoic Acid Receptor {beta} in Human Esophageal Squamous Cell Carcinoma
Clin. Cancer Res., November 1, 2003; 9(14): 5257 - 5263.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Watanabe, Y. Katayama, A. Yoshino, C. Komine, and T. Yokoyama
Deregulation of the TP53/p14ARF Tumor Suppressor Pathway in Low-Grade Diffuse Astrocytomas and Its Influence on Clinical Course
Clin. Cancer Res., October 15, 2003; 9(13): 4884 - 4890.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J.-P. J. Issa
Methylation and Prognosis: Of Molecular Clocks and Hypermethylator Phenotypes
Clin. Cancer Res., August 1, 2003; 9(8): 2879 - 2881.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Zhong, W. Yeo, M. W. Tang, N. Wong, P. B. S. Lai, and P. J. Johnson
Intensive Hypermethylation of the CpG Island of Ras Association Domain Family 1A in Hepatitis B Virus-associated Hepatocellular Carcinomas
Clin. Cancer Res., August 1, 2003; 9(9): 3376 - 3382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. O. O. Chan, S. K. Lam, B. C.-Y. Wong, Y.-L. Kwong, A. Rashid, and G. Tamura
Gene Methylation in Non-Neoplastic Mucosa of Gastric Cancer: Age or Helicobacter pylori Related?
Am. J. Pathol., July 1, 2003; 163(1): 370 - 373.
[Full Text] [PDF]

Home page
 Genome ResHome page
T. Ushijima, N. Watanabe, E. Okochi, A. Kaneda, T. Sugimura, and K. Miyamoto
Fidelity of the Methylation Pattern and Its Variation in the Genome
Genome Res., May 1, 2003; 13(5): 868 - 874.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
Y Kaneko, S Sakurai, M Hironaka, S Sato, S Oguni, Y Sakuma, K Sato, K Sugano, and K Saito
Distinct methylated profiles in Helicobacter pylori dependent and independent gastric MALT lymphomas
Gut, May 1, 2003; 52(5): 641 - 646.
[Abstract] [Full Text]

Home page
 GutHome page
A O-O Chan, S-K Lam, B C-Y Wong, W-M Wong, M-F Yuen, Y-H Yeung, W-M Hui, A Rashid, and Y-L Kwong
Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer
Gut, April 1, 2003; 52(4): 502 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Matsubayashi, N. Sato, N. Fukushima, C. J. Yeo, K. M. Walter, K. Brune, F. Sahin, R. H. Hruban, and M. Goggins
Methylation of Cyclin D2 Is Observed Frequently in Pancreatic Cancer but Is Also an Age-related Phenomenon in Gastrointestinal Tissues
Clin. Cancer Res., April 1, 2003; 9(4): 1446 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. N. Seril, J. Liao, G.-Y. Yang, and C. S. Yang
Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models
Carcinogenesis, March 1, 2003; 24(3): 353 - 362.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. M. Thomas, K. Haleem, A. B. Siddique, W. J. Simmons, N. Sen, D.-J. Zhang, and V. K. Tsiagbe
Regulation of Mouse Mammary Tumor Virus env Transcriptional Activator Initiated Mammary Tumor Virus Superantigen Transcripts in Lymphomas of SJL/J Mice: Role of Ikaros, Demethylation, and Chromatin Structural Change in the Transcriptional Activation of Mammary Tumor Virus Superantigen
J. Immunol., January 1, 2003; 170(1): 218 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Sato, D. Shibata, N. Harpaz, Y. Xu, J. Yin, Y. Mori, S. Wang, A. Olaru, E. Deacu, F. M. Selaru, et al.
Aberrant Methylation of the HPP1 Gene in Ulcerative Colitis-associated Colorectal Carcinoma
Cancer Res., December 1, 2002; 62(23): 6820 - 6822.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Yoon, S. Liyanarachchi, F. A. Wright, R. Davuluri, J. C. Lockman, A. de la Chapelle, and N. S. Pellegata
Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53
PNAS, November 26, 2002; 99(24): 15632 - 15637.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J.-P. Issa
Epigenetic Variation and Human Disease
J. Nutr., August 1, 2002; 132(8): 2388S - 2392.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Maier and A. Olek
Diabetes: A Candidate Disease for Efficient DNA Methylation Profiling
J. Nutr., August 1, 2002; 132(8): 2440S - 2443.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L. Shen, N. Ahuja, Y. Shen, N. A. Habib, M. Toyota, A. Rashid, and J.-P. J. Issa
DNA Methylation and Environmental Exposures in Human Hepatocellular Carcinoma
J Natl Cancer Inst, May 15, 2002; 94(10): 755 - 761.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
N. Fukushima, N. Sato, T. Ueki, C. Rosty, K. M. Walter, R. E. Wilentz, C. J. Yeo, R. H. Hruban, and M. Goggins
Aberrant Methylation of Preproenkephalin and p16 Genes in Pancreatic Intraepithelial Neoplasia and Pancreatic Ductal Adenocarcinoma
Am. J. Pathol., May 1, 2002; 160(5): 1573 - 1581.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Velicescu, D. J. Weisenberger, F. A. Gonzales, Y. C. Tsai, C. T. Nguyen, and P. A. Jones
Cell Division Is Required for de Novo Methylation of CpG Islands in Bladder Cancer Cells
Cancer Res., April 1, 2002; 62(8): 2378 - 2384.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Widschwendter and P. A. Jones
The Potential Prognostic, Predictive, and Therapeutic Values of DNA Methylation in Cancer : Commentary re: J. Kwong et al., Promoter Hypermethylation of Multiple Genes in Nasopharyngeal Carcinoma. Clin. Cancer Res., 8: 131-137, 2002, and H-Z. Zou et al., Detection of Aberrant p16 Methylation in the Serum of Colorectal Cancer Patients. Clin. Cancer Res., 8: 188-191, 2002.
Clin. Cancer Res., January 1, 2002; 8(1): 17 - 21.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Nakagawa, G. J. Nuovo, E. E. Zervos, E. W. Martin Jr., R. Salovaara, L. A. Aaltonen, and A. de la Chapelle
Age-related Hypermethylation of the 5' Region of MLH1 in Normal Colonic Mucosa Is Associated with Microsatellite-unstable Colorectal Cancer Development
Cancer Res., October 1, 2001; 61(19): 6991 - 6995.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.