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[Cancer Research 62, 43-47, January 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Psoriasin Expression in Mammary Epithelial Cells in Vitro and in Vivo1

Charlotta Enerbäck2, Dale A. Porter, Pankaj Seth, Dennis Sgroi, Justine Gaudet, Stanislawa Weremowicz, Cynthia C. Morton, Stuart Schnitt, Robert L. Pitts, Jason Stampl, Kerry Barnhart and Kornelia Polyak3

Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 [C. E., D. A. P., P. S., K. P.]; Department of Pathology, Massachusetts General Hospital, Charlestown, Massachusetts 02129 [D. S., J. G.]; Departments of Pathology [S. W., C. C. M.] and Obstetrics [C. C. M.], Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Boston, Massachusetts 02115; Department of Pathology, Beth-Israel Deaconess Medical Center, Boston, Massachusetts 02115 [S. S.]; Harvard Medical School, Boston, Massachusetts 02115 [C. E., D. A. P., P. S., D. S., S. W., C. C. M., S. S., K. P.]; and Imgenex Corporation, San Diego, California 92121 [R. L. P., J. S., K. B.]

We determined, by serial analysis of gene expression (SAGE) analysis of normal and DCIS (ductal carcinoma in situ) mammary epithelial cells, that psoriasin and several other genes implicated in psoriasis are aberrantly expressed in high-grade, comedo DCIS. Real-time PCR, mRNA in situ hybridization, and immunohistochemical analysis of breast carcinomas confirmed that psoriasin is frequently overexpressed in estrogen receptor-negative tumors. To gain insight into regulatory pathways that control psoriasin expression, we developed polyclonal and monoclonal antibodies and investigated mechanisms that may account for elevated levels of psoriasin in DCIS. Here, we report that loss of attachment to extracellular matrix, growth factor deprivation, and confluent conditions dramatically up-regulate psoriasin expression in MCF10A mammary epithelial cells. All of these conditions are characteristic of high-grade DCIS and psoriatic skin lesions; therefore, the same mechanisms may be responsible for increased expression of psoriasin in vitro and in vivo.




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Copyright © 2002 by the American Association for Cancer Research.