Cancer Research Cancer Epigenetics Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adini, A.
Right arrow Articles by Benjamin, L. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adini, A.
Right arrow Articles by Benjamin, L. E.
[Cancer Research 62, 2749-2752, May 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Placental Growth Factor Is a Survival Factor for Tumor Endothelial Cells and Macrophages1

Avner Adini2, Tad Kornaga2, Farshid Firoozbakht and Laura E. Benjamin3

Division of Cancer and Angiogenesis, Department of Pathology, The Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215

The vascular endothelial growth factor (VEGF)-related factor, placental growth factor (PlGF),has been shown recently to play an important role in pathological VEGF-driven angiogenesis.In this study, we examine the effects of mPlGF/PlGF-2 overexpression in tumors grown from glioma cells containing a tetracycline-regulated mPlGF cDNA. Overexpression of mPlGF leads to increased tumor growth and vascular survival. When tetracycline is used to abruptly withdraw mPlGF overexpression, we see increased apoptosis in both vascular cells and macrophages. In addition, PlGF-2 induces survival gene expression and inhibits apoptosis in vitro. Thus, we propose that PlGF-2 contributes to tumor angiogenesis by providing increased survival function to endothelial cells and macrophages.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
S. Loges, T. Schmidt, and P. Carmeliet
"Antimyeloangiogenic" Therapy for Cancer by Inhibiting PlGF
Clin. Cancer Res., June 1, 2009; 15(11): 3648 - 3653.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Nishimoto, M. Sakata, R. Minekawa, Y. Okamoto, A. Miyake, A. Isobe, T. Yamamoto, T. Takeda, E. Ishida, K. Sawada, et al.
Metal Transcription Factor-1 Is Involved in Hypoxia-Dependent Regulation of Placenta Growth Factor in Trophoblast-Derived Cells
Endocrinology, April 1, 2009; 150(4): 1801 - 1808.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Kurtagic, M. P. Jedrychowski, and M. A. Nugent
Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity
Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L534 - L546.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
Y. Cao
Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
Sci. Signal., February 24, 2009; 2(59): re1 - re1.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. Wu, B. L. Johnson, Y. Chen, C. T. Ha, and G. S. Dveksler
Murine Pregnancy-Specific Glycoprotein 23 Induces the Proangiogenic Factors Transforming-Growth Factor Beta 1 and Vascular Endothelial Growth Factor A in Cell Types Involved in Vascular Remodeling in Pregnancy
Biol Reprod, December 1, 2008; 79(6): 1054 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Kerber, Y. Reiss, A. Wickersheim, M. Jugold, F. Kiessling, M. Heil, V. Tchaikovski, J. Waltenberger, M. Shibuya, K. H. Plate, et al.
Flt-1 Signaling in Macrophages Promotes Glioma Growth In vivo
Cancer Res., September 15, 2008; 68(18): 7342 - 7351.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J.-i. Nishi, T. Minamino, H. Miyauchi, A. Nojima, K. Tateno, S. Okada, M. Orimo, J. Moriya, G.-H. Fong, K. Sunagawa, et al.
Vascular Endothelial Growth Factor Receptor-1 Regulates Postnatal Angiogenesis Through Inhibition of the Excessive Activation of Akt
Circ. Res., August 1, 2008; 103(3): 261 - 268.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Z. Zhang, N. E. Ramirez, T. E. Yankeelov, Z. Li, L. E. Ford, Y. Qi, A. Pozzi, and M. M. Zutter
{alpha}2{beta}1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner
Blood, February 15, 2008; 111(4): 1980 - 1988.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. V. Kozin, F. Winkler, I. Garkavtsev, D. J. Hicklin, R. K. Jain, and Y. Boucher
Human Tumor Xenografts Recurring after Radiotherapy Are More Sensitive to Anti-Vascular Endothelial Growth Factor Receptor-2 Treatment than Treatment-Naive Tumors
Cancer Res., June 1, 2007; 67(11): 5076 - 5082.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. P. Taylor and D. M. Goldenberg
Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts
Mol. Cancer Ther., February 1, 2007; 6(2): 524 - 531.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Wu, Z. Zhong, J. Huber, R. Bassi, B. Finnerty, E. Corcoran, H. Li, E. Navarro, P. Balderes, X. Jimenez, et al.
Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer.
Clin. Cancer Res., November 1, 2006; 12(21): 6573 - 6584.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Marcellini, N. De Luca, T. Riccioni, A. Ciucci, A. Orecchia, P. M. Lacal, F. Ruffini, M. Pesce, F. Cianfarani, G. Zambruno, et al.
Increased Melanoma Growth and Metastasis Spreading in Mice Overexpressing Placenta Growth Factor
Am. J. Pathol., August 1, 2006; 169(2): 643 - 654.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A R L Medford and A B Millar
Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?
Thorax, July 1, 2006; 61(7): 621 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. Iwama, S. Uemura, N. Naya, K.-i. Imagawa, Y. Takemoto, O. Asai, K. Onoue, S. Okayama, S. Somekawa, Y. Kida, et al.
Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction
J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1559 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S-C Wei, P-N Tsao, S-C Yu, C-T Shun, J-J Tsai-Wu, C H H Wu, Y-N Su, F-J Hsieh, and J-M Wong
Placenta growth factor expression is correlated with survival of patients with colorectal cancer
Gut, May 1, 2005; 54(5): 666 - 672.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Dalal, A. M. Berry, C. J. Cullinane, D. C. Mangham, R. Grimer, I. J. Lewis, C. Johnston, V. Laurence, and S. A. Burchill
Vascular Endothelial Growth Factor: A Therapeutic Target for Tumors of the Ewing's Sarcoma Family
Clin. Cancer Res., March 15, 2005; 11(6): 2364 - 2378.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. S. Wang, J. Teruya-Feldstein, Y. Wu, Z. Zhu, D. J. Hicklin, and M. A. S. Moore
Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
Blood, November 1, 2004; 104(9): 2893 - 2902.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. Ferrara
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
Endocr. Rev., August 1, 2004; 25(4): 581 - 611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Mac Gabhann and A. S. Popel
Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H153 - H164.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Cai, S. Ahmad, W. G. Jiang, J. Huang, C. D. Kontos, M. Boulton, and A. Ahmed
Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells
Diabetes, December 1, 2003; 52(12): 2959 - 2968.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
H Yoshiji, S Kuriyama, J Yoshii, Y Ikenaka, R Noguchi, D J Hicklin, Y Wu, K Yanase, T Namisaki, M Yamazaki, et al.
Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis
Gut, September 1, 2003; 52(9): 1347 - 1354.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
E. M. Conway, F. Zwerts, V. Van Eygen, A. DeVriese, N. Nagai, W. Luo, and D. Collen
Survivin-Dependent Angiogenesis in Ischemic Brain: Molecular Mechanisms of Hypoxia-Induced Up-Regulation
Am. J. Pathol., September 1, 2003; 163(3): 935 - 946.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
D. S. Torry, D. Mukherjea, J. Arroyo, and R. J. Torry
Expression and Function of Placenta Growth Factor: Implications for Abnormal Placentation
Reproductive Sciences, May 1, 2003; 10(4): 178 - 188.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J.N. UPALAKALIN, I. HEMO, C. DEHIO, E. KESHET, and L.E. BENJAMIN
Survival Mechanisms of VEGF and PlGF during Microvascular Remodeling
Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 181 - 188.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.