Cancer Research Cell Death Mechanisms and Cancer Therapy Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hewitt, S. C.
Right arrow Articles by Korach, K. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hewitt, S. C.
Right arrow Articles by Korach, K. S.
[Cancer Research 62, 2798-2805, May 15, 2002]
© 2002 American Association for Cancer Research

Carcinogenesis

Lack of Ductal Development in the Absence of Functional Estrogen Receptor {alpha} Delays Mammary Tumor Formation Induced by Transgenic Expression of ErbB2/neu

Sylvia Curtis Hewitt, Wayne P. Bocchinfuso1, Jun Zhai, Chuck Harrell, Linwood Koonce, James Clark, Page Myers and Kenneth S. Korach2

Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology [S. C. H., W. P. B., C. H., L. K., K. S. K. [and Comparative Medicine Branch [J. C., P. M.], National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, and Analytical Sciences, Inc., Durham, North Carolina 27713 [J. Z.]

Expression of the mouse mammary tumor virus (MMTV) neu/erbB2 transgene in mice induces mammary tumors. To examine the effect of removing estrogen receptor {alpha} (ER{alpha}) signaling on the ability of an MMTV-neu/erbB2 transgene to induce mammary tumors, the neu transgene was expressed in the ER{alpha} knockout ({alpha}ERKO) mouse, which lacks functional ER{alpha}. MMTV-neu females that lacked ER{alpha} still developed mammary tumors; however, tumor onset was significantly delayed. This study indicates that ER{alpha} is not required for mammary tumor induction by overexpression of neu/erbB2, but plays a role in the rate of tumor onset. The removal of ovarian steroid by ovariectomy in adults did not alter the onset rate. In contrast, prepubertal ovariectomy, which arrested mammary epithelial development, significantly delayed onset. In addition, manipulations that increase progesterone also accelerate the tumor onset, indicating the slower onset in the {alpha}ERKO is primarily attributable to the anovulatory phenotype resulting in lack of progesterone stimulation and a decreased abundance of target cells in the {alpha}ERKO mammary gland.




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
S. N. Sundar, C. N. Marconett, V. B. Doan, J. A. Willoughby Sr, and G. L. Firestone
Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells
Carcinogenesis, December 1, 2008; 29(12): 2252 - 2258.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. P. Fereshteh, M. T. Tilli, S. E. Kim, J. Xu, B. W. O'Malley, A. Wellstein, P. A. Furth, and A. T. Riegel
The Nuclear Receptor Coactivator Amplified in Breast Cancer-1 Is Required for Neu (ErbB2/HER2) Activation, Signaling, and Mammary Tumorigenesis in Mice
Cancer Res., May 15, 2008; 68(10): 3697 - 3706.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Padilla-Banks, W. N. Jefferson, and R. R. Newbold
Neonatal Exposure to the Phytoestrogen Genistein Alters Mammary Gland Growth and Developmental Programming of Hormone Receptor Levels
Endocrinology, October 1, 2006; 147(10): 4871 - 4882.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. Malewicz, Z. Wang, C. Jiang, J. Guo, M. P. Cleary, J. P. Grande, and J. Lu
Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements
Carcinogenesis, September 1, 2006; 27(9): 1739 - 1747.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Rossini, C. Rumio, L. Sfondrini, E. Tagliabue, D. Morelli, R. Miceli, L. Mariani, M. Palazzo, S. Menard, and A. Balsari
Influence of Antibiotic Treatment on Breast Carcinoma Development in Proto-neu Transgenic Mice.
Cancer Res., June 15, 2006; 66(12): 6219 - 6224.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Medina, F. S. Kittrell, J. Hill, A. Shepard, G. Thordarson, and P. Brown
Tamoxifen Inhibition of Estrogen Receptor-{alpha}-Negative Mouse Mammary Tumorigenesis
Cancer Res., April 15, 2005; 65(8): 3493 - 3496.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. S. Frech, E. D. Halama, M. T. Tilli, B. Singh, E. J. Gunther, L. A. Chodosh, J. A. Flaws, and P. A. Furth
Deregulated Estrogen Receptor {alpha} Expression in Mammary Epithelial Cells of Transgenic Mice Results in the Development of Ductal Carcinoma In situ
Cancer Res., February 1, 2005; 65(3): 681 - 685.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. H. Herynk and S. A. W. Fuqua
Estrogen Receptor Mutations in Human Disease
Endocr. Rev., December 1, 2004; 25(6): 869 - 898.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
G. M. Zinser and J. Welsh
Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice
Carcinogenesis, December 1, 2004; 25(12): 2361 - 2372.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S.-Q. Kuang, L. Liao, H. Zhang, A. V. Lee, B. W. O'Malley, and J. Xu
AIB1/SRC-3 Deficiency Affects Insulin-Like Growth Factor I Signaling Pathway and Suppresses v-Ha-ras-induced Breast Cancer Initiation and Progression in Mice
Cancer Res., March 1, 2004; 64(5): 1875 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Yeh, Y.-C. Hu, P.-H. Wang, C. Xie, Q. Xu, M.-Y. Tsai, Z. Dong, R.-S. Wang, T.-H. Lee, and C. Chang
Abnormal Mammary Gland Development and Growth Retardation in Female Mice and MCF7 Breast Cancer Cells Lacking Androgen Receptor
J. Exp. Med., December 15, 2003; 198(12): 1899 - 1908.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Medina, F. S. Kittrell, A. Shepard, A. Contreras, J. M. Rosen, and J. Lydon
Hormone Dependence in Premalignant Mammary Progression
Cancer Res., March 1, 2003; 63(5): 1067 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. R. Levin
Bidirectional Signaling between the Estrogen Receptor and the Epidermal Growth Factor Receptor
Mol. Endocrinol., March 1, 2003; 17(3): 309 - 317.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.