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[Cancer Research 62, 3009-3013, June 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

T-cell Factor-4 Frameshift Mutations Occur Frequently in Human Microsatellite Instability-high Colorectal Carcinomas but Do Not Contribute to Carcinogenesis1

Stefan Ruckert2, Elke Hiendlmeyer2, Wolfgang M. Brueckl2, Ursula Oswald, Kurt Beyser, Wolfgang Dietmaier, Angela Haynl, Claudia Koch, Josef Rüschoff, Thomas Brabletz, Thomas Kirchner and Andreas Jung3

Pathologisches Institut [S. R., E. H., U. O., A. H., C. K., T. B., T. K., A. J.] and Medizinische Klinik I [W. M. B.] der Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen; Institut für Pathologie, Klinikum Kassel, 34125 Kassel [K. B., J. R.]; and Pathologisches Institut der Universität Regensburg, 93053 Regensburg [W. D.], Germany

Colorectal carcinomas with microsatellite instability accumulate errors in short repetitive DNA repeats, especially mono and dinucleotide repeats. One such error-prone A9 monorepeat is found in exon 17 of the TCF-4 gene. TCF-4 and ß-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors. To elucidate the relevance of frameshift mutations in the TCF-4 in colorectal carcinogenesis, a variety of investigations in human tumors and cell lines was performed. It was found that mutations in the TCF-4 A9 repeat do not contribute to tumorigenesis and seem to be passenger mutations.




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Copyright © 2002 by the American Association for Cancer Research.