Cancer Research Grants Advances in Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khong, H. T.
Right arrow Articles by Rosenberg, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khong, H. T.
Right arrow Articles by Rosenberg, S. A.
[Cancer Research 62, 3020-3023, June 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

The Waardenburg Syndrome Type 4 Gene, SOX10, Is a Novel Tumor-associated Antigen Identified in a Patient with a Dramatic Response to Immunotherapy

Hung T. Khong and Steven A. Rosenberg1

Affiliation Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

In this study, we have identified, for the first time, the presence of de novo cellular immune reactivity against the transcription factor SOX10, using tumor-infiltrating lymphocytes obtained from a patient who experienced a dramatic clinical response to immunotherapy. SOX10 acts as a critical transactivator of tyrosinase-related protein-2 during melanoblast development and a potent transactivator of micropthalmia-associated transcription factor, which is considered to be a master gene that controls the development and postnatal survival of melanocytes. Mutations in SOX10 result in Waardenburg syndrome type 4. The overlapping epitopes AWISKPPGV and SAWISKPPGV, designated SOX10: 332–340 and SOX10: 331–340, respectively, were recognized by tumor-infiltrating lymphocyte clone M37 in an HLA-A2-restricted fashion.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Morokuma, D. Blackiston, D. S. Adams, G. Seebohm, B. Trimmer, and M. Levin
Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells
PNAS, October 28, 2008; 105(43): 16608 - 16613.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
M. Ferletta, L. Uhrbom, T. Olofsson, F. Ponten, and B. Westermark
Sox10 Has a Broad Expression Pattern in Gliomas and Enhances Platelet-Derived Growth Factor-B Induced Gliomagenesis
Mol. Cancer Res., September 1, 2007; 5(9): 891 - 897.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
N. H. Segal, P. Pavlidis, W. S. Noble, C. R. Antonescu, A. Viale, U. V. Wesley, K. Busam, H. Gallardo, D. DeSantis, M. F. Brennan, et al.
Classification of Clear-Cell Sarcoma as a Subtype of Melanoma by Genomic Profiling
J. Clin. Oncol., May 1, 2003; 21(9): 1775 - 1781.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Skoldberg, G. M. Portela-Gomes, L. Grimelius, G. Nilsson, J. Perheentupa, C. Betterle, E. S. Husebye, J. Gustafsson, A. Ronnblom, F. Rorsman, et al.
Histidine Decarboxylase, a Pyridoxal Phosphate-Dependent Enzyme, Is an Autoantigen of Gastric Enterochromaffin-Like Cells
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1445 - 1452.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.