Cancer Research Meeting Calendar Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sauter, E. R.
Right arrow Articles by Bastian, B. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sauter, E. R.
Right arrow Articles by Bastian, B. C.
[Cancer Research 62, 3200-3206, June 1, 2002]
© 2002 American Association for Cancer Research

Molecular Biology and Genetics

Cyclin D1 Is a Candidate Oncogene in Cutaneous Melanoma1

Edward R. Sauter, Un-Cheol Yeo, Andrea von Stemm, Weizhu Zhu, Samuel Litwin, David S. Tichansky, Giuseppa Pistritto, Mark Nesbit, Dan Pinkel, Meenhard Herlyn and Boris C. Bastian2

Departments of Dermatology and Pathology, University of California, San Francisco [U-C. Y., A. v. S., B. C. B.] and University of California San Francisco Comprehensive Cancer Center [D. P., B. C. B.], San Francisco, California 94143; The Wistar Institute, Philadelphia, Pennsylvania 19104 [E. R. S., D. S. T., G. P., M. N., M. H.]; Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 [E. R. S., W. Z.]; and Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 [S. L.]

The retinoblastoma pathway has been implicated in melanoma; however, previous studies of oneof the key components of this pathway, cyclin D1 (CD1), failed to find amplification of this gene in a large series of melanomas. We have recently shown that a particular subtype of melanoma, acral melanoma (AM), has frequent amplification of the CD1 locus. This suggested that CD1 might be important in AM and that it may also be important in other melanoma types, even though its copy number may not be altered. We compared CD1 gene copy number and protein expression in 137 invasive primary cutaneous melanomas (71 superficial spreading melanomas, 17 nodular melanomas, 19 lentigo maligna melanomas, 18 AMs, and 12 unclassifiable melanomas) using fluorescence in situ hybridization and immunohistochemistry. We found frequent amplification of CD1 in AM (44.4%) and occasional amplification in lentigo maligna melanoma (10.5%) and superficial spreading melanoma (5.6%). CD1 protein was overexpressed in all cases with amplifications and in an additional 20% of cases without amplification. We tested the importance of CD1 in cell growth in melanoma by using adenovirus-mediated antisense treatment targeted to CD1 in two melanoma cell lines, one with and the other without CD1 amplification and overexpression. Antisense mediated down-regulation of CD1 induced apoptosis in vitro and led to significant tumor shrinkage of melanoma xenografts in severe combined immunodeficient mice. However, it did not alter the growth of normal melanocytes. Together, these results suggest that CD1 may be an oncogene in melanoma and that targeting its expression may be therapeutically beneficial.




This article has been cited by other articles:


Home page
 INT J SURG PATHOLHome page
R. Z. Karim, W. Li, A. Sanki, M. H. Colman, Y. H. Yang, J. F. Thompson, and R. A. Scolyer
Reduced p16 and Increased Cyclin D1 and pRb Expression Are Correlated With Progression in Cutaneous Melanocytic Tumors
International Journal of Surgical Pathology, October 1, 2009; 17(5): 361 - 367.
[Abstract] [PDF]

Home page
 Clin. Cancer Res.Home page
K. A. Chernoff, L. Bordone, B. Horst, K. Simon, W. Twadell, K. Lee, J. A. Cohen, S. Wang, D. N. Silvers, G. Brunner, et al.
GAB2 Amplifications Refine Molecular Classification of Melanoma
Clin. Cancer Res., July 1, 2009; 15(13): 4288 - 4291.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. Horst, S. K. Gruvberger-Saal, B. D. Hopkins, L. Bordone, Y. Yang, K. A. Chernoff, I. Uzoma, V. Schwipper, J. Liebau, N. J. Nowak, et al.
Gab2-Mediated Signaling Promotes Melanoma Metastasis
Am. J. Pathol., April 1, 2009; 174(4): 1524 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Beadling, E. Jacobson-Dunlop, F. S. Hodi, C. Le, A. Warrick, J. Patterson, A. Town, A. Harlow, F. Cruz III, S. Azar, et al.
KIT Gene Mutations and Copy Number in Melanoma Subtypes
Clin. Cancer Res., November 1, 2008; 14(21): 6821 - 6828.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Wei, H.-C. Yang, H.-C. Chuang, J. Yang, S. K. Kulp, P.-J. Lu, M.-D. Lai, and C.-S. Chen
A Novel Mechanism by Which Thiazolidinediones Facilitate the Proteasomal Degradation of Cyclin D1 in Cancer Cells
J. Biol. Chem., September 26, 2008; 283(39): 26759 - 26770.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. S.M. Smalley, M. Lioni, M. D. Palma, M. Xiao, B. Desai, S. Egyhazi, J. Hansson, H. Wu, A. J. King, P. Van Belle, et al.
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas
Mol. Cancer Ther., September 1, 2008; 7(9): 2876 - 2883.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. S.M. Smalley, R. Contractor, T. K. Nguyen, M. Xiao, R. Edwards, V. Muthusamy, A. J. King, K. T. Flaherty, M. Bosenberg, M. Herlyn, et al.
Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression
Cancer Res., July 15, 2008; 68(14): 5743 - 5752.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. J. Molenaar, M. E. Ebus, J. Koster, P. v. Sluis, C. J.M. van Noesel, R. Versteeg, and H. N. Caron
Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma
Cancer Res., April 15, 2008; 68(8): 2599 - 2609.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
D. J. Son, M. H. Park, S. J. Chae, S. O. Moon, J. W. Lee, H. S. Song, D. C. Moon, S. S. Kang, Y. E. Kwon, and J. T. Hong
Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor {kappa}B
Mol. Cancer Ther., February 1, 2007; 6(2): 675 - 683.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. S. Spofford, E. V. Abel, K. Boisvert-Adamo, and A. E. Aplin
Cyclin D3 Expression in Melanoma Cells Is Regulated by Adhesion-dependent Phosphatidylinositol 3-Kinase Signaling and Contributes to G1-S Progression
J. Biol. Chem., September 1, 2006; 281(35): 25644 - 25651.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. J. Miller and M. C. Mihm Jr.
Melanoma.
N. Engl. J. Med., July 6, 2006; 355(1): 51 - 65.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
Z.-J. Liu, M. Xiao, K. Balint, K. S.M. Smalley, P. Brafford, R. Qiu, C. C. Pinnix, X. Li, and M. Herlyn
Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression.
Cancer Res., April 15, 2006; 66(8): 4182 - 4190.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. E. Elder
Pathology of melanoma.
Clin. Cancer Res., April 1, 2006; 12(7): 2308s - 2311s.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. A. Curtin, J. Fridlyand, T. Kageshita, H. N. Patel, K. J. Busam, H. Kutzner, K.-H. Cho, S. Aiba, E.-B. Brocker, P. E. LeBoit, et al.
Distinct Sets of Genetic Alterations in Melanoma
N. Engl. J. Med., November 17, 2005; 353(20): 2135 - 2147.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J Bondi, A Husdal, G Bukholm, J M Nesland, A Bakka, and I R K Bukholm
Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome
J. Clin. Pathol., May 1, 2005; 58(5): 509 - 514.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Syrovets, J. E. Gschwend, B. Buchele, Y. Laumonnier, W. Zugmaier, F. Genze, and T. Simmet
Inhibition of I{kappa}B Kinase Activity by Acetyl-boswellic Acids Promotes Apoptosis in Androgen-independent PC-3 Prostate Cancer Cells in Vitro and in Vivo
J. Biol. Chem., February 18, 2005; 280(7): 6170 - 6180.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Bales, L. Mills, N. Milam, M. McGahren-Murray, D. Bandyopadhyay, D. Chen, J. A. Reed, N. Timchenko, J. J. van den Oord, M. Bar-Eli, et al.
The Low Molecular Weight Cyclin E Isoforms Augment Angiogenesis and Metastasis of Human Melanoma Cells In vivo
Cancer Res., February 1, 2005; 65(3): 692 - 697.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Hoek, D. L. Rimm, K. R. Williams, H. Zhao, S. Ariyan, A. Lin, H. M. Kluger, A. J. Berger, E. Cheng, E. S. Trombetta, et al.
Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas
Cancer Res., August 1, 2004; 64(15): 5270 - 5282.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
J. J. Lucas, J. Domenico, and E. W. Gelfand
Cyclin-Dependent Kinase 6 Inhibits Proliferation of Human Mammary Epithelial Cells
Mol. Cancer Res., February 1, 2004; 2(2): 105 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. R. Alonso, P. Ortiz, M. Pollan, B. Perez-Gomez, L. Sanchez, M. J. Acuna, R. Pajares, F. J. Martinez-Tello, C. M. Hortelano, M. A. Piris, et al.
Progression in Cutaneous Malignant Melanoma Is Associated with Distinct Expression Profiles: A Tissue Microarray-Based Study
Am. J. Pathol., January 1, 2004; 164(1): 193 - 203.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. D. Yu, M. Becker-Hapak, E. L. Snyder, M. Vooijs, C. Denicourt, and S. F. Dowdy
Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival
PNAS, December 9, 2003; 100(25): 14881 - 14886.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. C. Bastian, A. B. Olshen, P. E. LeBoit, and D. Pinkel
Classifying Melanocytic Tumors Based on DNA Copy Number Changes
Am. J. Pathol., November 1, 2003; 163(5): 1765 - 1770.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. von Willebrand, E. Zacksenhaus, E. Cheng, P. Glazer, and R. Halaban
The Tyrphostin AG1024 Accelerates the Degradation of Phosphorylated Forms of Retinoblastoma Protein (pRb) and Restores pRb Tumor Suppressive Function in Melanoma Cells
Cancer Res., March 15, 2003; 63(6): 1420 - 1429.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.