Cancer Research Annual Meeting 2010 Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miura, K.
Right arrow Articles by Harris, C. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miura, K.
Right arrow Articles by Harris, C. C.
[Cancer Research 62, 3244-3250, June 1, 2002]
© 2002 American Association for Cancer Research

Molecular Biology and Genetics

Laser Capture Microdissection and Microarray Expression Analysis of Lung Adenocarcinoma Reveals Tobacco Smoking- and Prognosis-related Molecular Profiles1

Koh Miura, Elise D. Bowman, Richard Simon, Amy C. Peng, Ana I. Robles, Raymond T. Jones, Toyomasa Katagiri, Ping He, Hiroki Mizukami, Lu Charboneau, Takefumi Kikuchi, Lance A. Liotta, Yusuke Nakamura and Curtis C. Harris2

Laboratory of Human Carcinogenesis [K. M., E. D. B., A. I. R., P. H., C. C. H.], Biometric Research Branch, Division of Cancer Treatment and Diagnosis [R. S.] and Laboratory of Pathology [L. C., L. A. L.], National Cancer Institute, and Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases [H. M.], NIH, Bethesda, Maryland 20892; EMMES Corporation, Rockville, Maryland 20850 [A. C. P.]; Department of Pathology and Program in Oncology, University of Maryland, Baltimore, Maryland 21201 [R. T. J.]; and Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan [To. K., Ta. K., Y. N.]

Recent expression profile analyses revealed that lung adenocarcinomas canbe divided into several subgroups with diverse pathological features. Because cellular heterogeneity of tumors can confound these analyses, we used laser capture microdissection and microarray expression analysis to characterize the molecular profiles of lung adenocarcinomas. We found 45 genes delineating smokers and nonsmokers that were located at chromosomal loci frequently altered in non-small cell lung cancers, and 27 genes, which were differentially expressed between survivors and nonsurvivors 5 years after surgery. These results are consistent with the hypothesis that the abnormal expression of genes involved in maintaining the mitotic spindle checkpoint and genomic stability, e.g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor progression of tobacco smoke-induced adenocarcinoma of the lung.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
C. Speers, A. Tsimelzon, K. Sexton, A. M. Herrick, C. Gutierrez, A. Culhane, J. Quackenbush, S. Hilsenbeck, J. Chang, and P. Brown
Identification of Novel Kinase Targets for the Treatment of Estrogen Receptor-Negative Breast Cancer
Clin. Cancer Res., October 15, 2009; 15(20): 6327 - 6340.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Brambilla and A. Gazdar
Pathogenesis of lung cancer signalling pathways: roadmap for therapies
Eur. Respir. J., June 1, 2009; 33(6): 1485 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. C. Borczuk, R. L. Toonkel, and C. A. Powell
Genomics of Lung Cancer
Proceedings of the ATS, April 15, 2009; 6(2): 152 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. J. Fischer, K. L. Goss, T. E. Scheetz, C. L. Wohlford-Lenane, J. M. Snyder, and P. B. McCray Jr.
Differential Gene Expression in Human Conducting Airway Surface Epithelia and Submucosal Glands
Am. J. Respir. Cell Mol. Biol., February 1, 2009; 40(2): 189 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. J. Raz, M. R. Ray, J. Y. Kim, B. He, M. Taron, M. Skrzypski, M. Segal, D. R. Gandara, R. Rosell, and D. M. Jablons
A Multigene Assay Is Prognostic of Survival in Patients with Early-Stage Lung Adenocarcinoma
Clin. Cancer Res., September 1, 2008; 14(17): 5565 - 5570.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Fan, H. Ren, N. Jia, E. Fei, T. Zhou, P. Jiang, M. Wu, and G. Wang
DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity
J. Biol. Chem., February 15, 2008; 283(7): 4022 - 4030.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. A. D'Amico
Molecular Biologic Staging of Lung Cancer
Ann. Thorac. Surg., February 1, 2008; 85(2): S737 - S742.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. Seike, N. Yanaihara, E. D. Bowman, K. A. Zanetti, A. Budhu, K. Kumamoto, L. E. Mechanic, S. Matsumoto, J. Yokota, T. Shibata, et al.
Use of a Cytokine Gene Expression Signature in Lung Adenocarcinoma and the Surrounding Tissue as a Prognostic Classifier
J Natl Cancer Inst, August 15, 2007; 99(16): 1257 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
M C Boelens, A van den Berg, I Vogelzang, J Wesseling, D S Postma, W Timens, and H J M Groen
Differential expression and distribution of epithelial adhesion molecules in non-small cell lung cancer and normal bronchus
J. Clin. Pathol., June 1, 2007; 60(6): 608 - 614.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. E. Larsen, S. J. Pavey, L. H. Passmore, R. V. Bowman, N. K. Hayward, and K. M. Fong
Gene Expression Signature Predicts Recurrence in Lung Adenocarcinoma
Clin. Cancer Res., May 15, 2007; 13(10): 2946 - 2954.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. E. Larsen, S. J. Pavey, L. H. Passmore, R. Bowman, B. E. Clarke, N. K. Hayward, and K. M. Fong
Expression profiling defines a recurrence signature in lung squamous cell carcinoma
Carcinogenesis, March 1, 2007; 28(3): 760 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
N. Wakamatsu, T. R. devereux, H.-H. L. Hong, and R. C. Sills
Overview of the Molecular Carcinogenesis of Mouse Lung Tumor Models of Human Lung Cancer
Toxicol Pathol, January 1, 2007; 35(1): 75 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. C. Borczuk and C. A. Powell
Expression Profiling and Lung Cancer Development
Proceedings of the ATS, January 1, 2007; 4(1): 127 - 132.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. N. Hayes, S. Monti, G. Parmigiani, C. B. Gilks, K. Naoki, A. Bhattacharjee, M. A. Socinski, C. Perou, and M. Meyerson
Gene Expression Profiling Reveals Reproducible Human Lung Adenocarcinoma Subtypes in Multiple Independent Patient Cohorts
J. Clin. Oncol., November 1, 2006; 24(31): 5079 - 5090.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Raponi, Y. Zhang, J. Yu, G. Chen, G. Lee, J. M.G. Taylor, J. MacDonald, D. Thomas, C. Moskaluk, Y. Wang, et al.
Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung.
Cancer Res., August 1, 2006; 66(15): 7466 - 7472.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. El-Bayoumy, A. Das, B. Narayanan, N. Narayanan, E. S. Fiala, D. Desai, C. V. Rao, S. Amin, and R. Sinha
Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
Carcinogenesis, July 1, 2006; 27(7): 1369 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. L. Ubels, H. M. Hoffman, S. Srikanth, J. H. Resau, and C. P. Webb
Gene Expression in Rat Lacrimal Gland Duct Cells Collected Using Laser Capture Microdissection: Evidence for K+ Secretion by Duct Cells
Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1876 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
V. Nygaard and E. Hovig
Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling
Nucleic Acids Res., February 9, 2006; 34(3): 996 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. A. Granville and P. A. Dennis
An Overview of Lung Cancer Genomics and Proteomics
Am. J. Respir. Cell Mol. Biol., March 1, 2005; 32(3): 169 - 176.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Spira, J. Beane, V. Shah, G. Liu, F. Schembri, X. Yang, J. Palma, and J. S. Brody
Effects of cigarette smoke on the human airway epithelial cell transcriptome
PNAS, July 6, 2004; 101(27): 10143 - 10148.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. D. Petty, M. C. Nicolson, K. M. Kerr, E. Collie-Duguid, and G. I. Murray
Gene Expression Profiling in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application
Clin. Cancer Res., May 15, 2004; 10(10): 3237 - 3248.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. D. Hoang, J. D'Cunha, M. G. Kratzke, C. E. Casmey, S. P. Frizelle, M. A. Maddaus, and R. A. Kratzke
Gene Expression Profiling Identifies Matriptase Overexpression in Malignant Mesothelioma
Chest, May 1, 2004; 125(5): 1843 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Parmigiani, E. S. Garrett-Mayer, R. Anbazhagan, and E. Gabrielson
A Cross-Study Comparison of Gene Expression Studies for the Molecular Classification of Lung Cancer
Clin. Cancer Res., May 1, 2004; 10(9): 2922 - 2927.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
J. W. Gillespie, G. Gannot, M. A. Tangrea, M. Ahram, C. J.M. Best, V. E. Bichsel, E. F. Petricoin, M. R. Emmert-Buck, and R. F. Chuaqui
Molecular Profiling of Cancer
Toxicol Pathol, January 1, 2004; 32(1_suppl): 67 - 71.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. B. Copland, B. P. Kavanagh, D. Engelberts, C. McKerlie, J. Belik, and M. Post
Early Changes in Lung Gene Expression due to High Tidal Volume
Am. J. Respir. Crit. Care Med., November 1, 2003; 168(9): 1051 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
W. N. Rom and K.-M. Tchou-Wong
Functional Genomics in Lung Cancer and Biomarker Detection
Am. J. Respir. Cell Mol. Biol., August 1, 2003; 29(2): 153 - 156.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. P. Diggle, S. Cruickshank, J. D. Olsburgh, S. Pellegrin, B. Smith, R. E. Banks, P. J. Selby, M. A. Knowles, J. Southgate, and P. Harnden
Identification of Genes Up-Regulated in Urothelial Tumors: The 67-kd Laminin Receptor and Tumor-Associated Trypsin Inhibitor
Am. J. Pathol., August 1, 2003; 163(2): 493 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. J. Campa, M. Z. Wang, B. Howard, M. C. Fitzgerald, and E. F. Patz Jr.
Protein Expression Profiling Identifies Macrophage Migration Inhibitory Factor and Cyclophilin A as Potential Molecular Targets in Non-Small Cell Lung Cancer
Cancer Res., April 1, 2003; 63(7): 1652 - 1656.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. W. Kim and X. W. Wang
Gene expression profiling of preneoplastic liver disease and liver cancer: a new era for improved early detection and treatment of these deadly diseases?
Carcinogenesis, March 1, 2003; 24(3): 363 - 369.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R C Chambers
Gene expression profiling: good housekeeping and a clean message
Thorax, September 1, 2002; 57(9): 754 - 756.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.