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[Cancer Research 62, 3331-3334, June 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

3-Deoxy-3-[18F]Fluorothymidine-Positron Emission Tomography for Noninvasive Assessment of Proliferation in Pulmonary Nodules

Andreas K. Buck1, Holger Schirrmeister, Martin Hetzel, Mareike von der Heide, Gisela Halter, Gerhard Glatting, Torsten Mattfeldt, Florian Liewald, Sven N. Reske and Bernd Neumaier

Departments of Nuclear Medicine [A. K. B., H. S., M. v. d. H., G. G., S. N. R., B. N.], Internal Medicine II [M. H.], Thoracic Surgery [G. H., F. L.], and Pathology [T. M.], Universit of Ulm, D-89081 Ulm, Germany

We investigated whether uptake of the thymidine analogue 3-deoxy-3-[18F]fluorothymidine ([18F]FLT) reflects proliferation in solitary pulmonary nodules (SPNs). Thirty patients with SPNs were prospectively examined with positron emission tomography. Standardized uptake values were calculated for quantification of FLT uptake. Histopathology revealed 22 malignant and 8 benign lesions. Proliferation was evaluated by Ki-67 immunostaining and showed a mean proliferation fraction of 30.9% (range, 1–65%) in malignant SPNs and <5% in benign lesions. Linear regression analysis indicated a significant correlation between FLT-standardized uptake values and proliferative activity (P < 0.0001; r = 0.87). FLT uptake was specific for malignant lesions and may be used for differential diagnosis of SPNs, assessment of proliferation, and estimation of prognosis.




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