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[Cancer Research 62, 3347-3350, June 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Human Cytomegalovirus Infection and Expression in Human Malignant Glioma1

Charles S. Cobbs2, Lualhati Harkins, Minu Samanta, G. Yancey Gillespie, Suman Bharara, Peter H. King, L. Burt Nabors, C. Glenn Cobbs and William J. Britt

Surgical Service, Veterans Affairs Medical Center, Birmingham, Alabama [C. S. C., L. H., M. S.]; and Department of Surgery, Division of Neurosurgery [C. S. C., G. Y. G., S. B.], Department of Neurology [P. H. K., L. B. N.], Department of Medicine, Division of Infectious Diseases [C. G. C.], and Department of Pediatrics [W. J. B.], University of Alabama at Birmingham, Birmingham, Alabama 35294

Malignant gliomas are the most common primary brain tumors in adults, have no known etiology, and are generally rapidly fatal despite current therapies. Human cytomegalovirus (HCMV) is ß-herpesvirus trophic for glial cells that persistently infects 50–90% of the adult human population. HCMV can be reactivated under conditions of inflammation and immunosuppression, and HCMV gene products can dysregulate multiple cellular pathways involved in oncogenesis. Here we show that a high percentage of malignant gliomas are infected by HCMV and multiple HCMV gene products are expressed in these tumors. These data are the first to show an association between HCMV and malignant gliomas and suggest that HCMV may play an active role in glioma pathogenesis.




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Copyright © 2002 by the American Association for Cancer Research.