| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Immunogenetics Section, Department of Transfusion Medicine, Clinical Center [E. W., S. M., F. M. M.], Surgery Branch, Division of Clinical Sciences [G. A. O., A. P-D., H. R. A., N. P. R., S. A. R.], Biometric Research Branch, Division of Cancer Treatment and Diagnosis [Y. Z., R. S.], Center for Information Technology, Division of Clinical Science [J. I. P., E. A.], Surgical Pathology [P. H. D.], and Division of Clinical Sciences [E. T. L.], National Cancer Institute, NIH, Bethesda, Maryland 20892; Advanced Technology Center, National Cancer Institute, NIH, Gaithersburg, Maryland 20877 [L. D. M., D. P.]; and Wistar Institute, Philadelphia, Pennsylvania 19104 [M. H.]
We amplified RNAs from 63 fine needle aspiration (FNA) samples from 37 s.c. melanoma metastases from 25 patients undergoing immunotherapy for hybridization to a 6108-gene human cDNA chip. By prospectively following the history of the lesions, we could correlate transcript patterns with clinical outcome. Cluster analysis revealed a tight relationship among autologous synchronously sampled tumors compared with unrelated lesions (average Pearson’s r = 0.83 and 0.7, respectively, P < 0.0003). As reported previously, two subgroups of metastatic melanoma lesions were identified that, however, had no predictive correlation with clinical outcome. Ranking of gene expression data from pretreatment samples identified 
30 genes predictive of clinical response (P < 0.001). Analysis of their annotations denoted that approximately half of them were related to T-cell regulation, suggesting that immune responsiveness might be predetermined by a tumor microenvironment conducive to immune recognition.
This article has been cited by other articles:
|
|
 |
|
  A. Worschech, M. Kmieciak, K. L. Knutson, H. D. Bear, A. A. Szalay, E. Wang, F. M. Marincola, and M. H. Manjili Signatures Associated with Rejection or Recurrence in HER-2/neu-Positive Mammary Tumors Cancer Res., April 1, 2008; 68(7): 2436 - 2446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. McDermott and M. B. Atkins More Support for the Judicious Use of High-Dose Interleukin-2 in Patients With Advanced Melanoma J. Clin. Oncol., September 1, 2007; 25(25): 3791 - 3793. [Full Text] [PDF]
|
|
|
|
|
|
D. Becker, M. C. Mihm, S. M. Hewitt, V. K. Sondak, J. W. Fountain, and M. Thurin Markers and Tissue Resources for Melanoma: Meeting Report. Cancer Res., November 15, 2006; 66(22): 10652 - 10657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Amann, P. Chaurand, A. Gonzalez, J. A. Mobley, P. P. Massion, D. P. Carbone, and R. M. Caprioli Selective Profiling of Proteins in Lung Cancer Cells from Fine-Needle Aspirates by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry Clin. Cancer Res., September 1, 2006; 12(17): 5142 - 5150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Nair, M. O. Kilinc, S. A. Jones, and N. K. Egilmez Chronic Immune Therapy Induces a Progressive Increase in Intratumoral T Suppressor Activity and a Concurrent Loss of Tumor-Specific CD8+ T Effectors in her-2/neu Transgenic Mice Bearing Advanced Spontaneous Tumors. J. Immunol., June 15, 2006; 176(12): 7325 - 7334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Winnepenninckx, V. Lazar, S. Michiels, P. Dessen, M. Stas, S. R. Alonso, M.-F. Avril, P. L. Ortiz Romero, T. Robert, O. Balacescu, et al. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst, April 5, 2006; 98(7): 472 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. Gajewski Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment. Clin. Cancer Res., April 1, 2006; 12(7): 2326s - 2330s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Atkins Cytokine-based therapy and biochemotherapy for advanced melanoma. Clin. Cancer Res., April 1, 2006; 12(7): 2353s - 2358s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Basil, Y. Zhao, K. Zavaglia, P. Jin, M. C. Panelli, S. Voiculescu, S. Mandruzzato, H. M. Lee, B. Seliger, R. S. Freedman, et al. Common cancer biomarkers. Cancer Res., March 15, 2006; 66(6): 2953 - 2961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Cesana, G. DeRaffele, S. Cohen, D. Moroziewicz, J. Mitcham, J. Stoutenburg, K. Cheung, C. Hesdorffer, S. Kim-Schulze, and H. L. Kaufman Characterization of CD4+CD25+ Regulatory T Cells in Patients Treated With High-Dose Interleukin-2 for Metastatic Melanoma or Renal Cell Carcinoma J. Clin. Oncol., March 1, 2006; 24(7): 1169 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Nygaard and E. Hovig Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling Nucleic Acids Res., February 9, 2006; 34(3): 996 - 1014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. KAUFMAN Manipulating the Local Tumor Microenvironment with Poxviruses Expressing Costimulatory Molecules Ann. N.Y. Acad. Sci., December 1, 2005; 1062(1): 41 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Kirkwood Building Upon the Standard of Care in Adjuvant Therapy of High-Risk Melanoma J. Clin. Oncol., December 1, 2005; 23(34): 8559 - 8563. [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Gallagher, O. E. Bergin, M. Rafferty, Z. D. Kelly, I.-M. Nolan, E. J.P. Fox, A. C. Culhane, L. McArdle, M. F. Fraga, L. Hughes, et al. Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies Carcinogenesis, November 1, 2005; 26(11): 1856 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Panelli, E. Wang, and F. M. Marincola The Pathway to Biomarker Discovery: Carbonic Anhydrase IX and the Prediction of Immune Responsiveness Clin. Cancer Res., May 15, 2005; 11(10): 3601 - 3603. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bronte, T. Kasic, G. Gri, K. Gallana, G. Borsellino, I. Marigo, L. Battistini, M. Iafrate, T. Prayer-Galetti, F. Pagano, et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers J. Exp. Med., April 18, 2005; 201(8): 1257 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Wang, Y. Ngalame, M. C. Panelli, H. Nguyen-Jackson, M. Deavers, P. Mueller, W. Hu, C. A. Savary, R. Kobayashi, R. S. Freedman, et al. Peritoneal and Subperitoneal Stroma May Facilitate Regional Spread of Ovarian Cancer Clin. Cancer Res., January 1, 2005; 11(1): 113 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Wang, R. Lichtenfels, J. Bukur, Y. Ngalame, M. C. Panelli, B. Seliger, and F. M. Marincola Ontogeny and Oncogenesis Balance the Transcriptional Profile of Renal Cell Cancer Cancer Res., October 15, 2004; 64(20): 7279 - 7287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Monsurro, E. Wang, Y. Yamano, S. A. Migueles, M. C. Panelli, K. Smith, D. Nagorsen, M. Connors, S. Jacobson, and F. M. Marincola Quiescent phenotype of tumor-specific CD8+ T cells following immunization Blood, October 1, 2004; 104(7): 1970 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mocellin, E. Wang, M. Panelli, P. Pilati, and F. M. Marincola DNA Array-Based Gene Profiling in Tumor Immunology Clin. Cancer Res., July 15, 2004; 10(14): 4597 - 4606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Modlich, H.-B. Prisack, G. Pitschke, U. Ramp, R. Ackermann, H. Bojar, T. A. Vogeli, and M.-O. Grimm Identifying Superficial, Muscle-Invasive, and Metastasizing Transitional Cell Carcinoma of the Bladder: Use of cDNA Array Analysis of Gene Expression Profiles Clin. Cancer Res., May 15, 2004; 10(10): 3410 - 3421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Lim, A. Aggarwal, T. Agasthian, P.-S. Wong, C. Tan, E. Sim, L. Tan, P.-S. Goh, S.-C. Wang, K.-L. Khoo, et al. Feasibility of Using Low-Volume Tissue Samples for Gene Expression Profiling of Advanced Non-Small Cell Lung Cancers Clin. Cancer Res., December 1, 2003; 9(16): 5980 - 5987. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
