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[Cancer Research 62, 3581-3586, July 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Prospective Molecular Profiling of Melanoma Metastases Suggests Classifiers of Immune Responsiveness

Ena Wang, Lance D. Miller, Galen A. Ohnmacht, Simone Mocellin, Ainhoa Perez-Diez, David Petersen, Yingdong Zhao, Richard Simon, John I. Powell, Esther Asaki, H. Richard Alexander, Paul H. Duray, Meenhard Herlyn, Nicholas P. Restifo, Edison T. Liu, Steven A. Rosenberg and Francesco M. Marincola1

Immunogenetics Section, Department of Transfusion Medicine, Clinical Center [E. W., S. M., F. M. M.], Surgery Branch, Division of Clinical Sciences [G. A. O., A. P-D., H. R. A., N. P. R., S. A. R.], Biometric Research Branch, Division of Cancer Treatment and Diagnosis [Y. Z., R. S.], Center for Information Technology, Division of Clinical Science [J. I. P., E. A.], Surgical Pathology [P. H. D.], and Division of Clinical Sciences [E. T. L.], National Cancer Institute, NIH, Bethesda, Maryland 20892; Advanced Technology Center, National Cancer Institute, NIH, Gaithersburg, Maryland 20877 [L. D. M., D. P.]; and Wistar Institute, Philadelphia, Pennsylvania 19104 [M. H.]

We amplified RNAs from 63 fine needle aspiration (FNA) samples from 37 s.c. melanoma metastases from 25 patients undergoing immunotherapy for hybridization to a 6108-gene human cDNA chip. By prospectively following the history of the lesions, we could correlate transcript patterns with clinical outcome. Cluster analysis revealed a tight relationship among autologous synchronously sampled tumors compared with unrelated lesions (average Pearson’s r = 0.83 and 0.7, respectively, P < 0.0003). As reported previously, two subgroups of metastatic melanoma lesions were identified that, however, had no predictive correlation with clinical outcome. Ranking of gene expression data from pretreatment samples identified ~30 genes predictive of clinical response (P < 0.001). Analysis of their annotations denoted that approximately half of them were related to T-cell regulation, suggesting that immune responsiveness might be predetermined by a tumor microenvironment conducive to immune recognition.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
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Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
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Copyright © 2002 by the American Association for Cancer Research.