Cancer Research The Future of Cancer Research: Science and Patient Impact  Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Studeny, M.
Right arrow Articles by Andreeff, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Studeny, M.
Right arrow Articles by Andreeff, M.
[Cancer Research 62, 3603-3608, July 1, 2002]
© 2002 American Association for Cancer Research


Advances in Brief

Bone Marrow-derived Mesenchymal Stem Cells as Vehicles for Interferon-ß Delivery into Tumors1

Matus Studeny, Frank C. Marini, Richard E. Champlin, Claudia Zompetta, Isaiah J. Fidler and Michael Andreeff2

Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation [M. S., F. C. M., R. E. C., C. Z., M. A.], and Department of Cancer Biology [I. J. F.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

Molecules that physiologically control cell proliferation are often produced locally in tissues and are rapidly destroyed when they enter circulation. This allows local effects while avoiding interference with other systems. Unfortunately, it also limits the therapeutic use of these molecules via systemic delivery. We here demonstrate that, for the purpose of anticancer therapy, bone marrow-derived mesenchymal stem cells (MSCs) can produce biological agents locally at tumor sites. We show that the tumor microenvironment preferentially promotes the engraftment of MSCs as compared with other tissues. MSCs with forced expression of IFN-ß inhibited the growth of malignant cells in vivo. Importantly, this effect required the integration of MSCs into the tumors and could not be achieved by systemically delivered IFN-ß or by IFN-ß produced by MSCs at a site distant from the tumors. Our results indicate that MSCs may serve as a platform for delivery of biological agents in tumors.




This article has been cited by other articles:


Home page
Cancer Res.Home page
N. Eliopoulos, M. Francois, M.-N. Boivin, D. Martineau, and J. Galipeau
Neo-Organoid of Marrow Mesenchymal Stromal Cells Secreting Interleukin-12 for Breast Cancer Therapy
Cancer Res., June 15, 2008; 68(12): 4810 - 4818.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
P. J. Mishra, P. J. Mishra, R. Humeniuk, D. J. Medina, G. Alexe, J. P. Mesirov, S. Ganesan, J. W. Glod, and D. Banerjee
Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells
Cancer Res., June 1, 2008; 68(11): 4331 - 4339.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
G. Lazennec and C. Jorgensen
Concise Review: Adult Multipotent Stromal Cells and Cancer: Risk or Benefit?
Stem Cells, June 1, 2008; 26(6): 1387 - 1394.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
D. L. Troyer and M. L. Weiss
Concise Review: Wharton's Jelly-Derived Cells Are a Primitive Stromal Cell Population
Stem Cells, March 1, 2008; 26(3): 591 - 599.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. H. Klopp, E. L. Spaeth, J. L. Dembinski, W. A. Woodward, A. Munshi, R. E. Meyn, J. D. Cox, M. Andreeff, and F. C. Marini
Tumor Irradiation Increases the Recruitment of Circulating Mesenchymal Stem Cells into the Tumor Microenvironment
Cancer Res., December 15, 2007; 67(24): 11687 - 11695.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
A. J. Nauta and W. E. Fibbe
Immunomodulatory properties of mesenchymal stromal cells
Blood, November 15, 2007; 110(10): 3499 - 3506.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
G. Chamberlain, J. Fox, B. Ashton, and J. Middleton
Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
Stem Cells, November 1, 2007; 25(11): 2739 - 2749.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
R.M. Dwyer, S.M. Potter-Beirne, K.A. Harrington, A.J. Lowery, E. Hennessy, J.M. Murphy, F.P. Barry, T. O'Brien, and M.J. Kerin
Monocyte Chemotactic Protein-1 Secreted by Primary Breast Tumors Stimulates Migration of Mesenchymal Stem Cells
Clin. Cancer Res., September 1, 2007; 13(17): 5020 - 5027.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
L. Kucerova, V. Altanerova, M. Matuskova, S. Tyciakova, and C. Altaner
Adipose Tissue-Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy
Cancer Res., July 1, 2007; 67(13): 6304 - 6313.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
H. Xin, M. Kanehira, H. Mizuguchi, T. Hayakawa, T. Kikuchi, T. Nukiwa, and Y. Saijo
Targeted Delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells
Stem Cells, July 1, 2007; 25(7): 1618 - 1626.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
D. J. Prockop and S. D. Olson
Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions
Blood, April 15, 2007; 109(8): 3147 - 3151.
[Full Text] [PDF]


Home page
Stem CellsHome page
J. Tolar, A. J. Nauta, M. J. Osborn, A. Panoskaltsis Mortari, R. T. McElmurry, S. Bell, L. Xia, N. Zhou, M. Riddle, T. M. Schroeder, et al.
Sarcoma Derived from Cultured Mesenchymal Stem Cells
Stem Cells, February 1, 2007; 25(2): 371 - 379.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
L. G. Menon, S. Picinich, R. Koneru, H. Gao, S. Y. Lin, M. Koneru, P. Mayer-Kuckuk, J. Glod, and D. Banerjee
Differential Gene Expression Associated with Migration of Mesenchymal Stem Cells to Conditioned Medium from Tumor Cells or Bone Marrow Cells
Stem Cells, February 1, 2007; 25(2): 520 - 528.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
X.-c. Chen, R. Wang, X. Zhao, Y.-q. Wei, M. Hu, Y.-s. Wang, X.-w. Zhang, R. Zhang, L. Zhang, B. Yao, et al.
Prophylaxis against carcinogenesis in three kinds of unestablished tumor models via IL12-gene-engineered MSCs
Carcinogenesis, December 1, 2006; 27(12): 2434 - 2441.
[Abstract] [Full Text] [PDF]


Home page
ASH ANNUAL MEETING ABSTRACTSHome page
M. Andreeff, J. Dembinski, B. M. Hall, M. Studeny, X. Ling, M. Cabreira-Hansen, A. K. Sasser, T. McQueen, F. Lang, and F. C. Marini
Mesenchymal Stem Cells Selectively Engraft into Tumor Stroma and Produce Potent Antitumor Proteins In Situ.
Blood (ASH Annual Meeting Abstracts), November 16, 2006; 108(11): 352 - 352.
[Abstract] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
R. H. Lee, M. J. Seo, R. L. Reger, J. L. Spees, A. A. Pulin, S. D. Olson, and D. J. Prockop
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
PNAS, November 14, 2006; 103(46): 17438 - 17443.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
Y. Ikehara, T. Niwa, L. Biao, S. K. Ikehara, N. Ohashi, T. Kobayashi, Y. Shimizu, N. Kojima, and H. Nakanishi
A Carbohydrate Recognition-Based Drug Delivery and Controlled Release System using Intraperitoneal Macrophages as a Cellular Vehicle.
Cancer Res., September 1, 2006; 66(17): 8740 - 8748.
[Abstract] [Full Text] [PDF]


Home page
Br. J. Sports. Med.Home page
M Ramirez, A Lucia, F Gomez-Gallego, J Esteve-Lanao, A Perez-Martinez, C Foster, A L Andreu, M A Martin, L Madero, J Arenas, et al.
Mobilisation of mesenchymal cells into blood in response to skeletal muscle injury
Br. J. Sports Med., August 1, 2006; 40(8): 719 - 722.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
Y. Yu, J. Fuhr, E. Boye, S. Gyorffy, S. Soker, A. Atala, J. B. Mulliken, and J. Bischoff
Mesenchymal Stem Cells and Adipogenesis in Hemangioma Involution
Stem Cells, June 1, 2006; 24(6): 1605 - 1612.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
J. Stagg, S. Pommey, N. Eliopoulos, and J. Galipeau
Interferon-{gamma}-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell
Blood, March 15, 2006; 107(6): 2570 - 2577.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
S. Komarova, Y. Kawakami, M. A. Stoff-Khalili, D. T. Curiel, and L. Pereboeva
Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses.
Mol. Cancer Ther., March 1, 2006; 5(3): 755 - 766.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
P. A. Sotiropoulou, S. A. Perez, M. Salagianni, C. N. Baxevanis, and M. Papamichail
Characterization of the Optimal Culture Conditions for Clinical Scale Production of Human Mesenchymal Stem Cells
Stem Cells, February 1, 2006; 24(2): 462 - 471.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
P. Bosch, S. L. Pratt, and S. L. Stice
Isolation, Characterization, Gene Modification, and Nuclear Reprogramming of Porcine Mesenchymal Stem Cells
Biol Reprod, January 1, 2006; 74(1): 46 - 57.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
N. Eliopoulos, J. Stagg, L. Lejeune, S. Pommey, and J. Galipeau
Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice
Blood, December 15, 2005; 106(13): 4057 - 4065.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
S.-C. Hung, W.-P. Deng, W. K. Yang, R.-S. Liu, C.-C. Lee, T.-C. Su, R.-J. Lin, D.-M. Yang, C.-W. Chang, W.-H. Chen, et al.
Mesenchymal Stem Cell Targeting of Microscopic Tumors and Tumor Stroma Development Monitored by Noninvasive In vivo Positron Emission Tomography Imaging
Clin. Cancer Res., November 1, 2005; 11(21): 7749 - 7756.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. Krampera, A. Pasini, A. Rigo, M. T. Scupoli, C. Tecchio, G. Malpeli, A. Scarpa, F. Dazzi, G. Pizzolo, and F. Vinante
HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation
Blood, July 1, 2005; 106(1): 59 - 66.
[Abstract] [Full Text] [PDF]


Home page
Ann. N. Y. Acad. Sci.Home page
C. A. GREGORY, W. G. GUNN, E. REYES, A. J. SMOLARZ, J. MUNOZ, J. L. SPEES, and D. J. PROCKOP
How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow
Ann. N.Y. Acad. Sci., May 1, 2005; 1049(1): 97 - 106.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
A. Nakamizo, F. Marini, T. Amano, A. Khan, M. Studeny, J. Gumin, J. Chen, S. Hentschel, G. Vecil, J. Dembinski, et al.
Human Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Gliomas
Cancer Res., April 15, 2005; 65(8): 3307 - 3318.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
F. Marini, M. Studeny, and M. Andreeff
RESPONSE: Re: Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents
J Natl Cancer Inst, April 6, 2005; 97(7): 541 - 542.
[Full Text] [PDF]


Home page
Stem CellsHome page
S.-C. Hung, C.-Y. Lu, S.-K. Shyue, H.-C. Liu, and L. L.-T. Ho
Lineage Differentiation-Associated Loss of Adenoviral Susceptibility and Coxsackie-Adenovirus Receptor Expression in Human Mesenchymal Stem Cells
Stem Cells, December 1, 2004; 22(7): 1321 - 1329.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
M. Studeny, F. C. Marini, J. L. Dembinski, C. Zompetta, M. Cabreira-Hansen, B. N. Bekele, R. E. Champlin, and M. Andreeff
Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents
J Natl Cancer Inst, November 3, 2004; 96(21): 1593 - 1603.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
S. Vanderbyl, G. N. MacDonald, S. Sidhu, L. Gung, A. Telenius, C. Perez, and E. Perkins
Transfer and Stable Transgene Expression of a Mammalian Artificial Chromosome into Bone Marrow-Derived Human Mesenchymal Stem Cells
Stem Cells, May 1, 2004; 22(3): 324 - 333.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
T. Kinnaird, E. Stabile, M.S. Burnett, M. Shou, C.W. Lee, S. Barr, S. Fuchs, and S.E. Epstein
Local Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms
Circulation, March 30, 2004; 109(12): 1543 - 1549.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
F. Djouad, P. Plence, C. Bony, P. Tropel, F. Apparailly, J. Sany, D. Noel, and C. Jorgensen
Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
Blood, November 15, 2003; 102(10): 3837 - 3844.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
L. Pereboeva, S. Komarova, G. Mikheeva, V. Krasnykh, and D.T. Curiel
Approaches to Utilize Mesenchymal Progenitor Cells as Cellular Vehicles
Stem Cells, July 1, 2003; 21(4): 389 - 404.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.