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[Cancer Research 62, 3659-3662, July 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Inactivation of LKB1/STK11 Is a Common Event in Adenocarcinomas of the Lung1

Montserrat Sanchez-Cespedes2, Paola Parrella, Manel Esteller2, Shuji Nomoto, Barry Trink, James M. Engles, William H. Westra, James G. Herman and David Sidransky3

Department of Otolaryngology-Head and Neck Surgery, Head and Neck Cancer Research Division [M. S-C., P. P., S. N., B. T., J. M. E., D. S.], Oncology Center [M. E., J. G. H.], and Pathology Department [W. H. W.], Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196

Frequent losses of chromosome 19p have recently been observed in sporadic lung adenocarcinomas, targeting the location of a critical tumor suppressor gene. Here we performed fine mapping of the short arm of chromosome 19 and found that the LKB1/STK11 gene mapped in the minimal-deleted region. Because germ-line mutations at LKB1/STK11 result in the Peutz-Jeghers syndrome and an increased risk of cancer, we performed a detailed genetic screen of the LKB1/STK11 gene in lung tumors. We detected a high frequency of somatic alterations (mainly nonsense mutations) in primary lung adenocarcinomas and in lung cancer cell lines. Thus, our findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma.




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