Cancer Research Targets Frontiers in Basic Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bernardin, F.
Right arrow Articles by Friedman, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bernardin, F.
Right arrow Articles by Friedman, A. D.
[Cancer Research 62, 3904-3908, July 15, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

TEL-AML1, Expressed from t(12;21) in Human Acute Lymphocytic Leukemia, Induces Acute Leukemia in Mice1

Florence Bernardin2, Yandan Yang2, Rebecca Cleaves, Marianna Zahurak, Linzhao Cheng, Curt I. Civin and Alan D. Friedman3

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231

TEL-AML1 is expressed from the t(12;21) chromosomal translocation inB-precursor acute lymphocytic leukemia (ALL). Creation of the TEL-AML1fusion disrupts one copy of the TEL and AML1 genes, and loss of TEL or AML1 is also associated with cases of acute leukemia without TEL-AML1. To determine whether TEL-AML1 can contribute to leukemogenesis, we transduced marrow from C57BL/6 mice with a retroviral vector expressing TEL-AML1 or with a control vector. Transduced cells were introduced into irradiated syngeneic recipients. Two of 9 TEL-AML1 mice developed ALL (one T-lineage ALL and one B-precursor ALL), whereas 0 of 20 control mice developed leukemia. The B-precursor ALL was retransplantable and expressed TEL-AML1. We similarly transduced marrow from C57BL/6 mice lacking the overlapping p16INK4ap19ARF genes and transplanted the cells into wild-type recipients. No control mice died, but six of eight TEL-AML1/p16p19 mice died with leukemia. Overall, these findings indicate that TEL-AML1 contributes to leukemogenesis and may cooperate with loss of p16INK4ap14ARF to transform lymphoid progenitors.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
A. Inthal, G. Krapf, D. Beck, R. Joas, M. O. Kauer, L. Orel, G. Fuka, G. Mann, and E. R. Panzer-Grumayer
Role of the Erythropoietin Receptor in ETV6/RUNX1-Positive Acute Lymphoblastic Leukemia
Clin. Cancer Res., November 15, 2008; 14(22): 7196 - 7204.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Zhang, F. B. Fried, H. Guo, and A. D. Friedman
Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation
Blood, February 1, 2008; 111(3): 1193 - 1200.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. E. Sabaawy, M. Azuma, L. J. Embree, H.-J. Tsai, M. F. Starost, and D. D. Hickstein
TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia
PNAS, October 10, 2006; 103(41): 15166 - 15171.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. A.G. Stams, M. L. den Boer, H. B. Beverloo, J. P.P. Meijerink, E. R. van Wering, G. E. Janka-Schaub, and R. Pieters
Expression Levels of TEL, AML1, and the Fusion Products TEL-AML1 and AML1-TEL versus Drug Sensitivity and Clinical Outcome in t(12;21)-Positive Pediatric Acute Lymphoblastic Leukemia
Clin. Cancer Res., April 15, 2005; 11(8): 2974 - 2980.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Tsuzuki, M. Seto, M. Greaves, and T. Enver
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice
PNAS, June 1, 2004; 101(22): 8443 - 8448.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Morrow, S. Horton, D. Kioussis, H. J. M. Brady, and O. Williams
TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity
Blood, May 15, 2004; 103(10): 3890 - 3896.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Bernardin-Fried, T. Kummalue, S. Leijen, M. I. Collector, K. Ravid, and A. D. Friedman
AML1/RUNX1 Increases During G1 to S Cell Cycle Progression Independent of Cytokine-dependent Phosphorylation and Induces Cyclin D3 Gene Expression
J. Biol. Chem., April 9, 2004; 279(15): 15678 - 15687.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
V. P. S. Rawat, M. Cusan, A. Deshpande, W. Hiddemann, L. Quintanilla-Martinez, R. K. Humphries, S. K. Bohlander, M. Feuring-Buske, and C. Buske
Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia
PNAS, January 20, 2004; 101(3): 817 - 822.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. F. Greaves, A. T. Maia, J. L. Wiemels, and A. M. Ford
Leukemia in twins: lessons in natural history
Blood, October 1, 2003; 102(7): 2321 - 2333.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.