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SHPS-1

A Budding Molecule against Cancer Dissemination¹

Department of Molecular Pathogenesis [K. O., Y. I., M. H., S. M.], Second Department of Internal Medicine [K. M.] and First Department of Surgery [Y. N.], Nagoya University School of Medicine, Nagoya 466-8550, and Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606 [N. S.], Japan

The expression of SHPS-1 is down-regulated by several oncogene products such as v-Src in fibroblasts.In addition, the down-regulation of SHPS-1 is also found inhuman breast cancer tissues compared with the matched normal tissues. On the other hand, forced expression of SHPS-1 suppresses anchorage-independent cell growth of v-Src-transformed cells in vitro as well as peritoneal dissemination of the cells in nude mice. Surprisingly, the extracellular region (EC) of SHPS-1 seems to take part on the inhibitory effect. Because the EC domain interacts with fibronectin and DTT abrogates the inhibitory effects of the EC, we speculate that super-fibronectin may function with the EC as a suppressor of cancer cells. Here we show that SHPS-1 expression provides a unique potential that links suppression of anchorage-independent cell growth and cancer dissemination.

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