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The N-ras Proto-oncogene Can Suppress the Malignant Phenotype in the Presence or Absence of Its Oncogene¹

Departments of Pathology [R. D., D. A., M. M., I. P. d. C., J. L., N. F-M., R. M., J. T., R. G., A. P.] and Medicine [L. L-B., R. P-S.] and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, New York 10016

ras proto-oncogenes have traditionally been associated with the regulation and promotionof cell growth. We have induced thymic lymphomas in N-ras^-/- mice and intransgenic mice that overexpress wild-type N-ras and found that the lackof wild-type N-ras alleles favors the development of thymic lymphomas,whereas overexpression of wild-type N-ras protects against thymic lymphomagenesisin the presence or absence of its oncogene. To investigate the inhibitoryrole of wild-type N-ras in in vitro transformation, we introduced wild-type N-ras in N-ras-deficient tumor cells that lack ras activating mutations and found decreased growth in both low serum and soft agar. Taken together, our results indicate that wild-type N-ras has "tumor suppressor" activity, even in the absence of its oncogenic allele.

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