Cancer Research CR Surrogates Advances in Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, H.
Right arrow Articles by Wang, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, H.
Right arrow Articles by Wang, Z.
[Cancer Research 62, 4843-4848, September 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

HERG K+ Channel, a Regulator of Tumor Cell Apoptosis and Proliferation1

Huizhen Wang, Yiqiang Zhang, Liwen Cao, Hong Han, Jingxiong Wang, Baofeng Yang, Stanley Nattel and Zhiguo Wang2

Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, H1T 1C8 Canada

The human ether-a-go-go related gene (HERG) encodes K+ channel identifiedas a molecular target for mutations underlying some forms of thelong Q-T syndrome, a lethal cardiac arrhythmia. Recent studies revealed that HERG is abundantly expressed in a variety of tumor cells. Yet, the role of HERG in tumor cells had remained unclear. Here, we show that HERG conductance markedly promotes H2O2-induced apoptosis of various tumor cells, whereas HERG expression facilitates the tumor cell proliferation caused by tumor necrosis factor (TNF) ligand (TNF-{alpha}). Immunostaining and immunocoprecipitation reveal coexpression of HERG and TNF receptor 1 on the cytoplasmic membrane, which is correlated with greater activities of nuclear transcription factor, nuclear factor-{kappa}B, in HERG-expressing tumor cells. Our data suggest that HERG K+ channel is a regulator of tumor cell proliferation and apoptosis and provide a potential new target for cancer therapy.




This article has been cited by other articles:


Home page
 JNCI J Natl Cancer InstHome page
F. Di Costanzo, S. Gasperoni, L. Manzione, G. Bisagni, R. Labianca, S. Bravi, E. Cortesi, P. Carlini, R. Bracci, S. Tomao, et al.
Adjuvant Chemotherapy in Completely Resected Gastric Cancer: A Randomized Phase III Trial Conducted by GOIRC
J Natl Cancer Inst, March 19, 2008; 100(6): 388 - 398.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Luo, J. Xiao, H. Lin, Y. Lu, B. Yang, and Z. Wang
Genomic structure, transcriptional control, and tissue distribution of HERG1 and KCNQ1 genes
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1371 - H1380.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Xu, Y. Lu, Z. Pan, W. Chu, X. Luo, H. Lin, J. Xiao, H. Shan, Z. Wang, and B. Yang
The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes
J. Cell Sci., September 1, 2007; 120(17): 3045 - 3052.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Xiao, X. Luo, H. Lin, Y. Zhang, Y. Lu, N. Wang, Y. Zhang, B. Yang, and Z. Wang
MicroRNA miR-133 Represses HERG K+ Channel Expression Contributing to QT Prolongation in Diabetic Hearts
J. Biol. Chem., April 27, 2007; 282(17): 12363 - 12367.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
J. G. Pan and T. W. Mak
Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?
Sci. Signal., April 10, 2007; 2007(381): pe14 - pe14.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. J. Fay, X. Qian, Y. N. Jan, and L. Y. Jan
SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes
PNAS, November 14, 2006; 103(46): 17548 - 17553.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
H. Gao, J. Xiao, Q. Sun, H. Lin, Y. Bai, L. Yang, B. Yang, H. Wang, and Z. Wang
A Single Decoy Oligodeoxynucleotides Targeting Multiple Oncoproteins Produces Strong Anticancer Effects
Mol. Pharmacol., November 1, 2006; 70(5): 1621 - 1629.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. L. Cockerill and J. S. Mitcheson
Direct Block of Human Ether-a-go-go-Related Gene Potassium Channels by Caffeine
J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 860 - 868.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. Chapman, C. Ramstrom, L. Korhonen, M. Laine, K. T. Wann, D. Lindholm, M. Pasternack, and K. Tornquist
Downregulation of the HERG (KCNH2) K+ channel by ceramide: evidence for ubiquitin-mediated lysosomal degradation
J. Cell Sci., November 15, 2005; 118(22): 5325 - 5334.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Thomas, B. C. Hammerling, A.-B. Wimmer, K. Wu, E. Ficker, Y. A. Kuryshev, D. Scherer, J. Kiehn, H. A. Katus, W. Schoels, et al.
Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X)
Cardiovasc Res, December 1, 2004; 64(3): 467 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. S. McMurtry, S. Bonnet, X. Wu, J. R.B. Dyck, A. Haromy, K. Hashimoto, and E. D. Michelakis
Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis
Circ. Res., October 15, 2004; 95(8): 830 - 840.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
L. A. Pardo
Voltage-Gated Potassium Channels in Cell Proliferation
Physiology, October 1, 2004; 19(5): 285 - 292.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Beckley, B. U. Pauli, and R. C. Elble
Re-expression of Detachment-inducible Chloride Channel mCLCA5 Suppresses Growth of Metastatic Breast Cancer Cells
J. Biol. Chem., October 1, 2004; 279(40): 41634 - 41641.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Aydar, C. P. Palmer, and M. B. A. Djamgoz
Sigma Receptors and Cancer: Possible Involvement of Ion Channels
Cancer Res., August 1, 2004; 64(15): 5029 - 5035.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Han, H. Long, H. Wang, J. Wang, Y. Zhang, and Z. Wang
Progressive apoptotic cell death triggered by transient oxidative insult in H9c2 rat ventricular cells: a novel pattern of apoptosis and the mechanisms
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2169 - H2182.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Lastraioli, L. Guasti, O. Crociani, S. Polvani, G. Hofmann, H. Witchel, L. Bencini, M. Calistri, L. Messerini, M. Scatizzi, et al.
herg1 Gene and HERG1 Protein Are Overexpressed in Colorectal Cancers and Regulate Cell Invasion of Tumor Cells
Cancer Res., January 15, 2004; 64(2): 606 - 611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. V. Remillard and J. X.-J. Yuan
Activation of K+ channels: an essential pathway in programmed cell death
Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L49 - L67.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Lauritzen, M. Zanzouri, E. Honore, F. Duprat, M. U. Ehrengruber, M. Lazdunski, and A. J. Patel
K+-dependent Cerebellar Granule Neuron Apoptosis: ROLE OF TASK LEAK K+ CHANNELS
J. Biol. Chem., August 22, 2003; 278(34): 32068 - 32076.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Pei, O. Wiser, A. Slavin, D. Mu, S. Powers, L. Y. Jan, and T. Hoey
Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function
PNAS, June 24, 2003; 100(13): 7803 - 7807.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.