Cancer Research Landon Prizes for Basic and Translational Cancer Research Tumor Immunology: New Perspectives
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[Cancer Research 62, 4843-4848, September 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

HERG K+ Channel, a Regulator of Tumor Cell Apoptosis and Proliferation1

Huizhen Wang, Yiqiang Zhang, Liwen Cao, Hong Han, Jingxiong Wang, Baofeng Yang, Stanley Nattel and Zhiguo Wang2

Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, Quebec, H1T 1C8 Canada

The human ether-a-go-go related gene (HERG) encodes K+ channel identifiedas a molecular target for mutations underlying some forms of thelong Q-T syndrome, a lethal cardiac arrhythmia. Recent studies revealed that HERG is abundantly expressed in a variety of tumor cells. Yet, the role of HERG in tumor cells had remained unclear. Here, we show that HERG conductance markedly promotes H2O2-induced apoptosis of various tumor cells, whereas HERG expression facilitates the tumor cell proliferation caused by tumor necrosis factor (TNF) ligand (TNF-{alpha}). Immunostaining and immunocoprecipitation reveal coexpression of HERG and TNF receptor 1 on the cytoplasmic membrane, which is correlated with greater activities of nuclear transcription factor, nuclear factor-{kappa}B, in HERG-expressing tumor cells. Our data suggest that HERG K+ channel is a regulator of tumor cell proliferation and apoptosis and provide a potential new target for cancer therapy.




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Copyright © 2002 by the American Association for Cancer Research.