Cancer Research AACR Conference on Molecular Diagnostics - 2008 Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pan, Q.
Right arrow Articles by Merajver, S. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pan, Q.
Right arrow Articles by Merajver, S. D.
[Cancer Research 62, 4854-4859, September 1, 2002]
© 2002 American Association for Cancer Research

Advances in Brief

Copper Deficiency Induced by Tetrathiomolybdate Suppresses Tumor Growth and Angiogenesis1

Quintin Pan, Celina G. Kleer, Kenneth L. van Golen, Jennifer Irani, Kristen M. Bottema, Carlos Bias, Magda De Carvalho, Enrique A. Mesri, Diane M. Robins, Robert D. Dick, George J. Brewer2 and Sofia D. Merajver2,,3

Department of Internal Medicine, Division of Hematology and Oncology [Q. P., K. L. v. G., J. I., K. M. B., G. J. B., S. D. M.], Departments of Pathology [C. G. K.] and Human Genetics [D. M. R., R. D. D., G. J. B.], and Comprehensive Cancer Center [Q. P., C. G. K., K. L. v. G., K. M. B., S. D. M.], University of Michigan Medical School, Ann Arbor, Michigan 48109, and Laboratory of Viral Oncogenesis, Division of Hematology and Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021 [C. B., M. D. C., E. A. M.]

Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic acquire the ability to enter a phase of rapid growth and exhibit increased metastatic potential, the major cause of morbidity in cancer patients. We report that copper deficiency induced by tetrathiomolybdate (TM) significantly impairs tumor growth and angiogenesis in two animal models of breast cancer: an inflammatory breast cancer xenograft in nude mice and Her2/neu cancer-prone transgenic mice. In vitro, TM decreases the production of five proangiogenic mediators: (a) vascular endothelial growth factor; (b) fibroblast growth factor 2/basic fibroblast growth factor; (c) interleukin (IL)-1{alpha}; (d) IL-6; and (e) IL-8. In addition, TM inhibits vessel network formation and suppresses nuclear factor (NF){kappa}B levels and transcriptional activity. Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NF{kappa}B, contributing to a global inhibition of NF{kappa}B-mediated transcription of proangiogenic factors.




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
C. Zeng, G. Hou, R. Dick, and G. J. Brewer
Tetrathiomolybdate Is Partially Protective Against Hyperglycemia in Rodent Models of Diabetes
Experimental Biology and Medicine, August 1, 2008; 233(8): 1021 - 1025.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Juarez, M. Manuia, M. E. Burnett, O. Betancourt, B. Boivin, D. E. Shaw, N. K. Tonks, A. P. Mazar, and F. Donate
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling
PNAS, May 20, 2008; 105(20): 7147 - 7152.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Song, Z. Song, S. Barve, J. Zhang, T. Chen, M. Liu, G. E. Arteel, G. J. Brewer, and C. J. McClain
Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis
J. Pharmacol. Exp. Ther., May 1, 2008; 325(2): 409 - 416.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. Du, G. Filiz, A. Caragounis, P. J. Crouch, and A. R. White
Clioquinol Promotes Cancer Cell Toxicity through Tumor Necrosis Factor {alpha} Release from Macrophages
J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 360 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Bayliss, A. Hilger, P. Vishnu, K. Diehl, and D. El-Ashry
Reversal of the Estrogen Receptor Negative Phenotype in Breast Cancer and Restoration of Antiestrogen Response
Clin. Cancer Res., December 1, 2007; 13(23): 7029 - 7036.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
C. Guruvayoorappan and G. Kuttan
{beta}-Carotene Inhibits Tumor-Specific Angiogenesis by Altering the Cytokine Profile and Inhibits the Nuclear Translocation of Transcription Factors in B16F-10 Melanoma Cells
Integr Cancer Ther, September 1, 2007; 6(3): 258 - 270.
[Abstract] [PDF]

Home page
 J. Exp. Med.Home page
Y. Jiang, C. Reynolds, C. Xiao, W. Feng, Z. Zhou, W. Rodriguez, S. C. Tyagi, J. W. Eaton, J. T. Saari, and Y. J. Kang
Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice
J. Exp. Med., March 19, 2007; 204(3): 657 - 666.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. Hassouneh, M. Islam, T. Nagel, Q. Pan, S. D. Merajver, and T. N. Teknos
Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancer
Mol. Cancer Ther., March 1, 2007; 6(3): 1039 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Chen, Q. C. Cui, H. Yang, R. A. Barrea, F. H. Sarkar, S. Sheng, B. Yan, G. P. V. Reddy, and Q. P. Dou
Clioquinol, a Therapeutic Agent for Alzheimer's Disease, Has Proteasome-Inhibitory, Androgen Receptor-Suppressing, Apoptosis-Inducing, and Antitumor Activities in Human Prostate Cancer Cells and Xenografts
Cancer Res., February 15, 2007; 67(4): 1636 - 1644.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Yu, J. Wong, D. B. Lovejoy, D. S. Kalinowski, and D. R. Richardson
Chelators at the Cancer Coalface: Desferrioxamine to Triapine and Beyond
Clin. Cancer Res., December 1, 2006; 12(23): 6876 - 6883.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Chen, Q. C. Cui, H. Yang, and Q. P. Dou
Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity
Cancer Res., November 1, 2006; 66(21): 10425 - 10433.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty and K. I. Block
Preadministration of High-Dose Salicylates, Suppressors of NF-{kappa}B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy.
Integr Cancer Ther, September 1, 2006; 5(3): 252 - 268.
[Abstract] [PDF]

Home page
 Clin. Cancer Res.Home page
J. C. Juarez, O. Betancourt Jr., S. R. Pirie-Shepherd, X. Guan, M. L. Price, D. E. Shaw, A. P. Mazar, and F. Donate
Copper Binding by Tetrathiomolybdate Attenuates Angiogenesis and Tumor Cell Proliferation through the Inhibition of Superoxide Dismutase 1.
Clin. Cancer Res., August 15, 2006; 12(16): 4974 - 4982.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty and K. I. Block
Toward a core nutraceutical program for cancer management.
Integr Cancer Ther, June 1, 2006; 5(2): 150 - 171.
[Abstract] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
M. K. Khan, F. Mamou, M. J. Schipper, K. S. May, A. Kwitny, A. Warnat, B. Bolton, B. M. Nair, M. S. T. Kariapper, M. Miller, et al.
Combination tetrathiomolybdate and radiation therapy in a mouse model of head and neck squamous cell carcinoma.
Arch Otolaryngol Head Neck Surg, March 1, 2006; 132(3): 333 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. L. Payne, B. Fogelgren, A. R. Hess, E. A. Seftor, E. L. Wiley, S. F.T. Fong, K. Csiszar, M. J.C. Hendrix, and D. A. Kirschmann
Lysyl Oxidase Regulates Breast Cancer Cell Migration and Adhesion through a Hydrogen Peroxide-Mediated Mechanism
Cancer Res., December 15, 2005; 65(24): 11429 - 11436.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty and K. I. Block
Multifocal Angiostatic Therapy: An Update
Integr Cancer Ther, December 1, 2005; 4(4): 301 - 314.
[Abstract] [PDF]

Home page
 Neuro OncolHome page
S. Brem, S. A. Grossman, K. A. Carson, P. New, S. Phuphanich, J. B. Alavi, T. Mikkelsen, J. D. Fisher, and for the New Approaches to Brain Tumor Therapy CNS
Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma
Neuro-oncol, July 1, 2005; 7(3): 246 - 253.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
W.-Q. Ding, B. Liu, J. L. Vaught, H. Yamauchi, and S. E. Lind
Anticancer Activity of the Antibiotic Clioquinol
Cancer Res., April 15, 2005; 65(8): 3389 - 3395.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
T. N. Teknos, M. Islam, D. A. Arenberg, Q. Pan, S. L. Carskadon, A. M. Abarbanell, B. Marcus, S. Paul, C. D. Vandenberg, M. Carron, et al.
The Effect of Tetrathiomolybdate on Cytokine Expression, Angiogenesis, and Tumor Growth in Squamous Cell Carcinoma of the Head and Neck
Arch Otolaryngol Head Neck Surg, March 1, 2005; 131(3): 204 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Matsumoto, J.-i. Namekawa, M. Muta, T. Nakamura, H. Bando, K. Tohyama, M. Toi, and K. Umezawa
Targeting of Nuclear Factor {kappa}B Pathways by Dehydroxymethylepoxyquinomicin, a Novel Inhibitor of Breast Carcinomas: Antitumor and Antiangiogenic Potential In vivo
Clin. Cancer Res., February 1, 2005; 11(3): 1287 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. G. Elner, V. M. Elner, A. Yoshida, R. D. Dick, and G. J. Brewer
Effects of Tetrathiomolybdate in a Mouse Model of Retinal Neovascularization
Invest. Ophthalmol. Vis. Sci., January 1, 2005; 46(1): 299 - 303.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty
Targeting Multiple Signaling Pathways as a Strategy for Managing Prostate Cancer: Multifocal Signal Modulation Therapy
Integr Cancer Ther, December 1, 2004; 3(4): 349 - 380.
[Abstract] [PDF]

Home page
 Exp. Biol. Med.Home page
F. K. Askari, R. Dick, M. Mao, and G. J. Brewer
Tetrathiomolybdate Therapy Protects Against Concanavalin A and Carbon Tetrachloride Hepatic Damage in Mice
Experimental Biology and Medicine, September 1, 2004; 229(8): 857 - 863.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
I. Prudovsky, A. Mandinova, R. Soldi, C. Bagala, I. Graziani, M. Landriscina, F. Tarantini, M. Duarte, S. Bellum, H. Doherty, et al.
The non-classical export routes: FGF1 and IL-1{alpha} point the way
J. Cell Sci., December 15, 2003; 116(24): 4871 - 4881.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
Q. Pan, L. W. Bao, and S. D. Merajver
Tetrathiomolybdate Inhibits Angiogenesis and Metastasis Through Suppression of the NF{kappa}B Signaling Cascade
Mol. Cancer Res., August 1, 2003; 1(10): 701 - 706.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
C. Cox, S. D. Merajver, S. Yoo, R. D. Dick, G. J. Brewer, J. S.-J. Lee, and T. N. Teknos
Inhibition of the Growth of Squamous Cell Carcinoma by Tetrathiomolybdate-Induced Copper Suppression in a Murine Model
Arch Otolaryngol Head Neck Surg, July 1, 2003; 129(7): 781 - 785.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Q. Pan, L. W. Bao, C. G. Kleer, G. J. Brewer, and S. D. Merajver
Antiangiogenic Tetrathiomolybdate Enhances the Efficacy of Doxorubicin against Breast Carcinoma
Mol. Cancer Ther., July 1, 2003; 2(7): 617 - 622.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Mandinova, R. Soldi, I. Graziani, C. Bagala, S. Bellum, M. Landriscina, F. Tarantini, I. Prudovsky, and T. Maciag
S100A13 mediates the copper-dependent stress-induced release of IL-1{alpha} from both human U937 and murine NIH 3T3 cells
J. Cell Sci., July 1, 2003; 116(13): 2687 - 2696.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Mandinov, A. Mandinova, S. Kyurkchiev, D. Kyurkchiev, I. Kehayov, V. Kolev, R. Soldi, C. Bagala, E. D. de Muinck, V. Lindner, et al.
Copper chelation represses the vascular response to injury
PNAS, May 27, 2003; 100(11): 6700 - 6705.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. G. Redman, P. Esper, Q. Pan, R. L. Dunn, H. K. Hussain, T. Chenevert, G. J. Brewer, and S. D. Merajver
Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer
Clin. Cancer Res., May 1, 2003; 9(5): 1666 - 1672.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.