| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
ING1b is a candidate tumor suppressor that can stimulate the transcriptionalactivity of p53 and inhibit cell proliferation. The molecular basis of how ING1b activates p53 function remains unclear. Here we show that ING1b could stimulate the activity of p53 by increasing the level and stability of the p53 protein. The stabilization and activation of p53 by ING1b could be reversed by MDM2 in a dose-dependent manner. Conversely, ING1b could reverse the inhibition and degradation of p53 caused by MDM2 in a dose-dependent manner. Furthermore, ING1b and MDM2 bound to p53 in a mutually exclusive manner. In agreement with these observations, we found that similarly to MDM2, ING1b binds to the NH2-terminal region of p53. These data suggest a model in which ING1b disrupts the interaction between p53 and MDM2, leading to the stabilization of p53 and growth inhibition.
This article has been cited by other articles:
|
|
 |
|
  H. Jung, H.-A Seong, and H. Ha Critical Role of Cysteine Residue 81 of Macrophage Migration Inhibitory Factor (MIF) in MIF-induced Inhibition of p53 Activity J. Biol. Chem., July 18, 2008; 283(29): 20383 - 20396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jung, H.-A. Seong, and H. Ha NM23-H1 Tumor Suppressor and Its Interacting Partner STRAP Activate p53 Function J. Biol. Chem., November 30, 2007; 282(48): 35293 - 35307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Garate, E. I. Campos, J. A. Bush, H. Xiao, and G. Li Phosphorylation of the tumor suppressor p33ING1b at Ser-126 influences its protein stability and proliferation of melanoma cells FASEB J, November 1, 2007; 21(13): 3705 - 3716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Abad, C. Menendez, A. Fuchtbauer, M. Serrano, E.-M. Fuchtbauer, and I. Palmero Ing1 Mediates p53 Accumulation and Chromatin Modification in Response to Oncogenic Stress J. Biol. Chem., October 19, 2007; 282(42): 31060 - 31067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Chan and R. Y.C. Poon The p53 Isoform {Delta}p53 Lacks Intrinsic Transcriptional Activity and Reveals the Critical Role of Nuclear Import in Dominant-Negative Activity Cancer Res., March 1, 2007; 67(5): 1959 - 1969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Coles, H. Liang, Z. Zhu, C. G.A. Marfella, J. Kang, A. N. Imbalzano, and S. N. Jones Deletion of p37Ing1 in Mice Reveals a p53-Independent Role for Ing1 in the Suppression of Cell Proliferation, Apoptosis, and Tumorigenesis Cancer Res., March 1, 2007; 67(5): 2054 - 2061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Hammond, D. J. Mandell, A. Salim, A. J. Krieg, T. M. Johnson, H. A. Shirazi, L. D. Attardi, and A. J. Giaccia Genome-Wide Analysis of p53 under Hypoxic Conditions. Mol. Cell. Biol., May 1, 2006; 26(9): 3492 - 3504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Gong, M. Russell, K. Suzuki, and K. Riabowol Subcellular Targeting of p33ING1b by Phosphorylation-Dependent 14-3-3 Binding Regulates p21WAF1 Expression Mol. Cell. Biol., April 15, 2006; 26(8): 2947 - 2954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Chan, M. C. Mak, T. K. Fung, A. Lau, W. Y. Siu, and R. Y.C. Poon Ubiquitination of p53 at Multiple Sites in the DNA-Binding Domain Mol. Cancer Res., January 1, 2006; 4(1): 15 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Chan, W. Y. Siu, A. Lau, and R. Y. C. Poon How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer? Mol. Cell. Biol., April 15, 2004; 24(8): 3536 - 3551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vieyra, D. L. Senger, T. Toyam, H. Muzik, P. M. A. Brasher, R. N. Johnston, K. Riabowol, and P. A. Forsyth Altered Subcellular Localization and Low Frequency of Mutations of ING1 in Human Brain Tumors Clin. Cancer Res., December 1, 2003; 9(16): 5952 - 5961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kataoka, P. Bonnefin, D. Vieyra, X. Feng, Y. Hara, Y. Miura, T. Joh, H. Nakabayashi, H. Vaziri, C. C. Harris, et al. ING1 Represses Transcription by Direct DNA Binding and through Effects on p53 Cancer Res., September 15, 2003; 63(18): 5785 - 5792. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
