| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Carcinogenesis |
Division of Cancer Research, Medical Research Institute [T. O.] and Department of Pathology [M. M., M. Tan.], Kanazawa Medical University, Ishikawa 920-0293, Japan; Department of Molecular Radiobiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan [S. S., H. K., Z-B. H., F. S., M. Tat.]; and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455 [Y. T.]
Phosphorylation of histone H3 at Ser-10 is required for maintenance of properchromosome dynamics during mitosis. AIM-1, a mammalian Ipl1/aurora kinase involved in H3 phosphorylation, is transcriptionally overexpressed in many tumor cell lines. Increased expression of the AIM-1 gene has been observed in human colorectal tumors of advanced grade and stage. Here we report that forced exogenous overexpression of AIM-1 in Chinese hamster embryo cells causes increased mitotic Ser-10 phosphorylation with concomitant induction of lagging chromosomes during mitosis. Lagging chromosomes could also be induced by transfection with mutated histone H3 (S10E), which is thought to maintain Ser-10 in the phosphorylated state. In the present study, chromosome number instability and increased tumor invasiveness were noted in constitutively AIM-1-overexpressing cells in vivo. Increased mitotic Ser-10 phosphorylation was also observed in various colorectal tumor cells with high AIM-1 expression levels. These data suggest that increased H3 histone phosphorylation as a result of AIM-1 overexpression is a major precipitating factor of chromosome instability and, thus, may play a role in carcinogenesis.
This article has been cited by other articles:
|
|
 |
|
  Y. Arlot-Bonnemains, E. Baldini, B. Martin, J.-G. Delcros, M. Toller, F. Curcio, F. S Ambesi-Impiombato, M. D'Armiento, and S. Ulisse Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines Endocr. Relat. Cancer, June 1, 2008; 15(2): 559 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Man, J. Rosa, Y. L. Yip, A. L.-M. Cheung, Y. L. Kwong, S. J. Doxsey, and S. W. Tsao Id1 Overexpression Induces Tetraploidization and Multiple Abnormal Mitotic Phenotypes by Modulating Aurora A Mol. Biol. Cell, June 1, 2008; 19(6): 2389 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-G. Kim, K. W. Lee, Y.-Y. Cho, N. J. Kang, S.-M. Oh, A. M. Bode, and Z. Dong Mitogen- and Stress-Activated Kinase 1-Mediated Histone H3 Phosphorylation Is Crucial for Cell Transformation Cancer Res., April 1, 2008; 68(7): 2538 - 2547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Gautschi, J. Heighway, P. C. Mack, P. R. Purnell, P. N. Lara Jr., and D. R. Gandara Aurora Kinases as Anticancer Drug Targets Clin. Cancer Res., March 15, 2008; 14(6): 1639 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Choi, B. S. Kang, J.-H. Shim, Y.-Y. Cho, B. Y. Choi, A. M. Bode, and Z. Dong Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity FASEB J, January 1, 2008; 22(1): 113 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Kulkarni, M. Loddo, E. Leo, M. Rashid, K. L. Eward, T. R. Fanshawe, J. Butcher, A. Frost, J. A. Ledermann, G. H. Williams, et al. DNA Replication Licensing Factors and Aurora Kinases are Linked to Aneuploidy and Clinical Outcome in Epithelial Ovarian Carcinoma Clin. Cancer Res., October 15, 2007; 13(20): 6153 - 6161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-Y. Cho, K. Yao, H.-G. Kim, B. S. Kang, D. Zheng, A. M. Bode, and Z. Dong Ribosomal S6 Kinase 2 Is a Key Regulator in Tumor Promoter Induced Cell Transformation Cancer Res., September 1, 2007; 67(17): 8104 - 8112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ito Role of Histone Modification in Chromatin Dynamics J. Biochem., May 1, 2007; 141(5): 609 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Hontz, S. A. Li, W. L. Lingle, V. Negron, A. Bruzek, J. L. Salisbury, and J. J. Li Aurora A and B Overexpression and Centrosome Amplification in Early Estrogen-Induced Tumor Foci in the Syrian Hamster Kidney: Implications for Chromosomal Instability, Aneuploidy, and Neoplasia Cancer Res., April 1, 2007; 67(7): 2957 - 2963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fu, M. Bian, Q. Jiang, and C. Zhang Roles of Aurora Kinases in Mitosis and Tumorigenesis Mol. Cancer Res., January 1, 2007; 5(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Monier, S. Mouradian, and K. F. Sullivan DNA methylation promotes Aurora-B-driven phosphorylation of histone H3 in chromosomal subdomains J. Cell Sci., January 1, 2007; 120(1): 101 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Carvajal, A. Tse, and G. K. Schwartz Aurora Kinases: New Targets for Cancer Therapy Clin. Cancer Res., December 1, 2006; 12(23): 6869 - 6875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Vischioni, J. J. Oudejans, W. Vos, J. A. Rodriguez, and G. Giaccone Frequent overexpression of aurora B kinase, a novel drug target, in non-small cell lung carcinoma patients. Mol. Cancer Ther., November 1, 2006; 5(11): 2905 - 2913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Y. Lee, A. Frolov, R. Li, G. Ayala, and N. M. Greenberg Targeting aurora kinases for the treatment of prostate cancer. Cancer Res., May 15, 2006; 66(10): 4996 - 5002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Sarg, W. Helliger, H. Talasz, B. Forg, and H. H. Lindner Histone H1 Phosphorylation Occurs Site-specifically during Interphase and Mitosis: IDENTIFICATION OF A NOVEL PHOSPHORYLATION SITE ON HISTONE H1 J. Biol. Chem., March 10, 2006; 281(10): 6573 - 6580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tamada, N. V. Thuan, P. Reed, D. Nelson, N. Katoku-Kikyo, J. Wudel, T. Wakayama, and N. Kikyo Chromatin Decondensation and Nuclear Reprogramming by Nucleoplasmin Mol. Cell. Biol., February 15, 2006; 26(4): 1259 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Caldas, M P Holloway, B M Hall, S J Qualman, and R A Altura Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo J. Med. Genet., February 1, 2006; 43(2): 119 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Monaco, U. Kolthur-Seetharam, R. Loury, J. M.-d. Murcia, G. de Murcia, and P. Sassone-Corsi Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage PNAS, October 4, 2005; 102(40): 14244 - 14248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Choi, B. Y. Choi, Y.-Y. Cho, H. Mizuno, B. S. Kang, A. M. Bode, and Z. Dong Phosphorylation of Histone H3 at Serine 10 Is Indispensable for Neoplastic Cell Transformation Cancer Res., July 1, 2005; 65(13): 5818 - 5827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Nguyen, D. Chinnappan, T. Urano, and K. Ravid Mechanism of Aurora-B Degradation and Its Dependency on Intact KEN and A-Boxes: Identification of an Aneuploidy-Promoting Property Mol. Cell. Biol., June 15, 2005; 25(12): 4977 - 4992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bode and Z. Dong Inducible Covalent Posttranslational Modification of Histone H3 Sci. Signal., April 26, 2005; 2005(281): re4 - re4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Choi, B. Y. Choi, Y.-Y. Cho, F. Zhu, A. M. Bode, and Z. Dong Phosphorylation of Ser28 in Histone H3 Mediated by Mixed Lineage Kinase-like Mitogen-activated Protein Triple Kinase {alpha} J. Biol. Chem., April 8, 2005; 280(14): 13545 - 13553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. E. Nikiforov Anaplastic Carcinoma of the Thyroid--Will Aurora B Light a Path for Treatment? J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1243 - 1245. [Full Text] [PDF]
|
|
|
|
|
|
R. Sorrentino, S. Libertini, P. L. Pallante, G. Troncone, L. Palombini, V. Bavetsias, D. Spalletti-Cernia, P. Laccetti, S. Linardopoulos, P. Chieffi, et al. Aurora B Overexpression Associates with the Thyroid Carcinoma Undifferentiated Phenotype and Is Required for Thyroid Carcinoma Cell Proliferation J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 928 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Allison and J. Milner Remodelling chromatin on a global scale: a novel protective function of p53 Carcinogenesis, September 1, 2004; 25(9): 1551 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Moggs and G. Orphanides The Role of Chromatin in Molecular Mechanisms of Toxicity Toxicol. Sci., August 1, 2004; 80(2): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, Y. Nagata, G. Yu, H. G. Nguyen, M. R. Jones, P. Toselli, C. W. Jackson, M. Tatsuka, K. Todokoro, and K. Ravid Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression Blood, May 15, 2004; 103(10): 3717 - 3726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ramaswamy, J. S. Williams, K. M. Robinson, R. L. Sopko, and M. C. Schultz Global Control of Histone Modification by the Anaphase-Promoting Complex Mol. Cell. Biol., December 15, 2003; 23(24): 9136 - 9149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Allison and J. Milner Loss of p53 Has Site-Specific Effects on Histone H3 Modification, Including Serine 10 Phosphorylation Important for Maintenance of Ploidy Cancer Res., October 15, 2003; 63(20): 6674 - 6679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-H. Yih and T.-C. Lee Induction of C-Anaphase and Diplochromosome through Dysregulation of Spindle Assembly Checkpoint by Sodium Arsenite in Human Fibroblasts Cancer Res., October 15, 2003; 63(20): 6680 - 6688. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Cell Growth & Differentiation |
