Cancer Research Cancer Research Funding Available Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thimmulappa, R. K.
Right arrow Articles by Biswal, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thimmulappa, R. K.
Right arrow Articles by Biswal, S.
[Cancer Research 62, 5196-5203, September 15, 2002]
© 2002 American Association for Cancer Research

Carcinogenesis

Identification of Nrf2-regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray1

Rajesh K. Thimmulappa, Kim H. Mai, Sorachai Srisuma, Thomas W. Kensler, Masayuki Yamamoto and Shyam Biswal2

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205-2179 [R. K. T., K. H. M., S. S., T. W. K., S. B.], and Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, 305-8577 Japan [M. Y.]

Electrophiles formed during metabolic activation of chemical carcinogens and reactive oxygen species generated from endogenous and exogenous sources play a significant role in carcinogenesis. Cancer chemoprevention by induction of phase 2 proteins to counteract the insults of these reactive intermediates has gained considerable attention. Nuclear factor E2 p45-related factor 2 (Nrf2), a bZIP transcription factor, plays a central role in the regulation (basal and or inducible expression) of phase 2 genes by binding to the "antioxidant response element" in their promoters. Identification of novel Nrf2-regulated genes is likely to provide insight into cellular defense systems against the toxicities of electrophiles and oxidants and may define effective targets for achieving cancer chemoprevention. Sulforaphane is a promising chemopreventive agent that exerts its effect by strong induction of phase 2 enzymes via activation of Nrf2. In the present study, a transcriptional profile of small intestine of wild-type (nrf2 +/+) and knock out (nrf2 -/-) mice treated with vehicle or sulforaphane (9 µmol/day for 1 week, p.o.) was generated using the Murine Genome U74Av2 oligonucleotide array (representing ~6000 well-characterized genes and nearly 6000 expressed sequence tags). Comparative analysis of gene expression changes between different treatment groups of wild-type and nrf2-deficient mice facilitated identification of numerous genes regulated by Nrf2 including previously reported Nrf2-regulated genes such as NAD(P)H:quinone reductase (NQO1), glutathione S-transferase (GST), {gamma}-glutamylcysteine synthetase (GCS), UDP-glucuronosyltransferases (UGT),epoxide hydrolase, as well as a number of new genes. Also identified were genes encoding for cellular NADPH regenerating enzymes (glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and malic enzyme), various xenobiotic metabolizing enzymes, antioxidants (glutathione peroxidase, glutathione reductase, ferritin, and haptaglobin), and biosynthetic enzymes of the glutathione and glucuronidation conjugation pathways. The data were validated by Northern blot analysis and enzyme assays of selected genes. This investigation expands the horizon of Nrf2-regulated genes, highlights the cross-talk between various metabolic pathways, and divulges the pivotal role played by Nrf2 in regulating cellular defenses against carcinogens and other toxins.




This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Zakkar, K. Van der Heiden, L. A. Luong, H. Chaudhury, S. Cuhlmann, S. S. Hamdulay, R. Krams, I. Edirisinghe, I. Rahman, H. Carlsen, et al.
Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State
Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1851 - 1857.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
R. L. Yeager, S. A. Reisman, L. M. Aleksunes, and C. D. Klaassen
Introducing the "TCDD-Inducible AhR-Nrf2 Gene Battery"
Toxicol. Sci., October 1, 2009; 111(2): 238 - 246.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. O. Kelleher, M. McMahon, I. M. Eggleston, M. J. Dixon, K. Taguchi, M. Yamamoto, and J. D. Hayes
1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic {alpha},{beta}-unsaturated aldehyde acrolein
Carcinogenesis, October 1, 2009; 30(10): 1754 - 1762.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A.K. MacLeod, M. McMahon, S. M. Plummer, L. G. Higgins, T. M. Penning, K. Igarashi, and J. D. Hayes
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
Carcinogenesis, September 1, 2009; 30(9): 1571 - 1580.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. S. Yates, Q. T. Tran, P. M. Dolan, W. O. Osburn, S. Shin, C. C. McCulloch, J. B. Silkworth, K. Taguchi, M. Yamamoto, C. R. Williams, et al.
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
Carcinogenesis, June 1, 2009; 30(6): 1024 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
D. B. Buckley and C. D. Klaassen
Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor {alpha}, and Nuclear Factor Erythroid 2-Related Factor 2
Drug Metab. Dispos., April 1, 2009; 37(4): 847 - 856.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. A. Reisman, R. L. Yeager, M. Yamamoto, and C. D. Klaassen
Increased Nrf2 Activation in Livers from Keap1-Knockdown Mice Increases Expression of Cytoprotective Genes that Detoxify Electrophiles more than those that Detoxify Reactive Oxygen Species
Toxicol. Sci., March 1, 2009; 108(1): 35 - 47.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Rushworth, D. J. MacEwan, and M. A. O'Connell
Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes
J. Immunol., November 15, 2008; 181(10): 6730 - 6737.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. H. Noyan-Ashraf, Z. Sadeghinejad, G. F. Davies, A. R. Ross, D. Saucier, T. A. A. Harkness, and B. H. J. Juurlink
Phase 2 Protein Inducers in the Diet Promote Healthier Aging
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2008; 63(11): 1168 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Singh, S. Boldin-Adamsky, R. K. Thimmulappa, S. K. Rath, H. Ashush, J. Coulter, A. Blackford, S. N. Goodman, F. Bunz, W. H. Watson, et al.
RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy
Cancer Res., October 1, 2008; 68(19): 7975 - 7984.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. L. Adair-Kirk, J. J. Atkinson, G. L. Griffin, M. A. Watson, D. G. Kelley, D. DeMello, R. M. Senior, and T. Betsuyaku
Distal Airways in Mice Exposed to Cigarette Smoke: Nrf2-Regulated Genes Are Increased in Clara Cells
Am. J. Respir. Cell Mol. Biol., October 1, 2008; 39(4): 400 - 411.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Xue, Q. Qian, A. Adaikalakoteswari, N. Rabbani, R. Babaei-Jadidi, and P. J. Thornalley
Activation of NF-E2-Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease
Diabetes, October 1, 2008; 57(10): 2809 - 2817.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Malhotra, R. Thimmulappa, A. Navas-Acien, A. Sandford, M. Elliott, A. Singh, L. Chen, X. Zhuang, J. Hogg, P. Pare, et al.
Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1
Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 592 - 604.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. K. Meja, S. Rajendrasozhan, D. Adenuga, S. K. Biswas, I. K. Sundar, G. Spooner, J. A. Marwick, P. Chakravarty, D. Fletcher, P. Whittaker, et al.
Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2
Am. J. Respir. Cell Mol. Biol., September 1, 2008; 39(3): 312 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. L. Rouse, G. Murphy, M. J. Boudreaux, D. B. Paulsen, and A. L. Penn
Soot Nanoparticles Promote Biotransformation, Oxidative Stress, and Inflammation in Murine Lungs
Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 198 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Mastrangelo, A. Cassidy, F. Mulholland, W. Wang, and Y. Bao
Serotonin Receptors, Novel Targets of Sulforaphane Identified by Proteomic Analysis in Caco-2 Cells
Cancer Res., July 1, 2008; 68(13): 5487 - 5491.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
X.-J. Wang, Z. Sun, N. F. Villeneuve, S. Zhang, F. Zhao, Y. Li, W. Chen, X. Yi, W. Zheng, G. T. Wondrak, et al.
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
Carcinogenesis, June 1, 2008; 29(6): 1235 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
H. Takakusa, H. Masumoto, A. Mitsuru, O. Okazaki, and K. Sudo
Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes
Drug Metab. Dispos., May 1, 2008; 36(5): 816 - 823.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
G. Murphy Jr., R. L. Rouse, W. W. Polk, W. G. Henk, S. A. Barker, M. J. Boudreaux, Z. E. Floyd, and A. L. Penn
Combustion-Derived Hydrocarbons Localize to Lipid Droplets in Respiratory Cells
Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 532 - 540.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
H. Sarioglu, S. Brandner, M. Haberger, C. Jacobsen, J. Lichtmannegger, M. Wormke, and U. Andrae
Analysis of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced Proteome Changes in 5L Rat Hepatoma Cells Reveals Novel Targets of Dioxin Action Including the Mitochondrial Apoptosis Regulator VDAC2
Mol. Cell. Proteomics, February 1, 2008; 7(2): 394 - 410.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
X. Zhao, G. Sun, J. Zhang, R. Strong, P. K. Dash, Y. W. Kan, J. C. Grotta, and J. Aronowski
Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage
Stroke, December 1, 2007; 38(12): 3280 - 3286.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
V. Misra, H. Lee, A. Singh, K. Huang, R. K. Thimmulappa, W. Mitzner, S. Biswal, and C. G. Tankersley
Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes
Physiol Genomics, November 14, 2007; 31(3): 429 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
M. Rokushima, K. Omi, K. Imura, A. Araki, N. Furukawa, F. Itoh, M. Miyazaki, J. Yamamoto, M. Rokushima, M. Okada, et al.
Toxicogenomics of Drug-Induced Hemolytic Anemia by Analyzing Gene Expression Profiles in the Spleen
Toxicol. Sci., November 1, 2007; 100(1): 290 - 302.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Zhao, A. N. Moore, J. B. Redell, and P. K. Dash
Enhancing Expression of Nrf2-Driven Genes Protects the Blood Brain Barrier after Brain Injury
J. Neurosci., September 19, 2007; 27(38): 10240 - 10248.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Iwasaki, K. Hailemariam, and Y. Tsuji
PIAS3 Interacts with ATF1 and Regulates the Human Ferritin H Gene through an Antioxidant-responsive Element
J. Biol. Chem., August 3, 2007; 282(31): 22335 - 22343.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
B. S. Cornblatt, L. Ye, A. T. Dinkova-Kostova, M. Erb, J. W. Fahey, N. K. Singh, M.-S. A. Chen, T. Stierer, E. Garrett-Mayer, P. Argani, et al.
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
Carcinogenesis, July 1, 2007; 28(7): 1485 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
L. M. Aleksunes and J. E. Manautou
Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease
Toxicol Pathol, June 1, 2007; 35(4): 459 - 473.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. F. Baker, T. Landowski, R. Dorr, W. R. Tate, J. M.C. Gard, B. E. Tavenner, T. Dragovich, A. Coon, and G. Powis
The Antitumor Agent Imexon Activates Antioxidant Gene Expression: Evidence for an Oxidative Stress Response
Clin. Cancer Res., June 1, 2007; 13(11): 3388 - 3394.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
X. Wang, D. J. Tomso, B. N. Chorley, H.-Y. Cho, V. G. Cheung, S. R. Kleeberger, and D. A. Bell
Identification of polymorphic antioxidant response elements in the human genome
Hum. Mol. Genet., May 15, 2007; 16(10): 1188 - 1200.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. G. Kim and S. J. Lee
PI3K, RSK, and mTOR Signal Networks for the GST Gene Regulation
Toxicol. Sci., April 1, 2007; 96(2): 206 - 213.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-F. Yueh and R. H. Tukey
Nrf2-Keap1 Signaling Pathway Regulates Human UGT1A1 Expression in Vitro and in Transgenic UGT1 Mice
J. Biol. Chem., March 23, 2007; 282(12): 8749 - 8758.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Balbir, H. Lee, M. Okumura, S. Biswal, R. S. Fitzgerald, and M. Shirahata
A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice
Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L704 - L715.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. Pledgie-Tracy, M. D. Sobolewski, and N. E. Davidson
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
Mol. Cancer Ther., March 1, 2007; 6(3): 1013 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-C. Lo and M. Hannink
PGAM5, a Bcl-XL-interacting Protein, Is a Novel Substrate for the Redox-regulated Keap1-dependent Ubiquitin Ligase Complex
J. Biol. Chem., December 8, 2006; 281(49): 37893 - 37903.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. O. Leonard, N. E. Kieran, K. Howell, M. J. Burne, R. Varadarajan, S. Dhakshinamoorthy, A. G. Porter, C. O'Farrelly, H. Rabb, and C. T. Taylor
Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury
FASEB J, December 1, 2006; 20(14): 2624 - 2626.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Li, S.-W. Yu, and A.-N. T. Kong
Nrf2 Possesses a Redox-sensitive Nuclear Exporting Signal in the Neh5 Transactivation Domain
J. Biol. Chem., September 15, 2006; 281(37): 27251 - 27263.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Wan and D. Diaz-Sanchez
Phase II Enzymes Induction Blocks the Enhanced IgE Production in B Cells by Diesel Exhaust Particles.
J. Immunol., September 1, 2006; 177(5): 3477 - 3483.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
C. Goldring, N. Kitteringham, R. Jenkins, I. Copple, J.-F. Jeannin, and B. K. Park
Plasticity in cell defence: access to and reactivity of critical protein residues and DNA response elements
J. Exp. Biol., June 15, 2006; 209(12): 2337 - 2343.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
H. Lou, S. Du, Q. Ji, and A. Stolz
Induction of AKR1C2 by Phase II Inducers: Identification of a Distal Consensus Antioxidant Response Element Regulated by NRF2
Mol. Pharmacol., May 1, 2006; 69(5): 1662 - 1672.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X.-L. Chen, G. Dodd, S. Thomas, X. Zhang, M. A. Wasserman, B. H. Rovin, and C. Kunsch
Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1862 - H1870.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. C. Myzak, K. Hardin, R. Wang, R. H. Dashwood, and E. Ho
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
Carcinogenesis, April 1, 2006; 27(4): 811 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
T. Umemura, Y. Kuroiwa, Y. Kitamura, Y. Ishii, K. Kanki, Y. Kodama, K. Itoh, M. Yamamoto, A. Nishikawa, and M. Hirose
A Crucial Role of Nrf2 in In Vivo Defense against Oxidative Damage by an Environmental Pollutant, Pentachlorophenol
Toxicol. Sci., March 1, 2006; 90(1): 111 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
G. Shen, C. Xu, R. Hu, M. R. Jain, A. Gopalkrishnan, S. Nair, M.-T. Huang, J. Y. Chan, and A.-N. T. Kong
Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin
Mol. Cancer Ther., January 1, 2006; 5(1): 39 - 51.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C.-T. Yeh and G.-C. Yen
Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells
Carcinogenesis, December 1, 2005; 26(12): 2138 - 2148.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Y.-J. Surh, J. K. Kundu, H.-K. Na, and J.-S. Lee
Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals
J. Nutr., December 1, 2005; 135(12): 2993S - 3001S.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Y. Shih, P. Li, and T. H. Murphy
A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia In Vivo
J. Neurosci., November 2, 2005; 25(44): 10321 - 10335.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
T. W. Kensler, J.-G. Chen, P. A. Egner, J. W. Fahey, L. P. Jacobson, K. K. Stephenson, L. Ye, J. L. Coady, J.-B. Wang, Y. Wu, et al.
Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a Randomized Clinical Trial in He Zuo Township, Qidong, People's Republic of China
Cancer Epidemiol. Biomarkers Prev., November 1, 2005; 14(11): 2605 - 2613.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. J. Hintze and E. C. Theil
DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression
PNAS, October 18, 2005; 102(42): 15048 - 15052.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-J. Kim and A. E. Nel
The Role of Phase II Antioxidant Enzymes in Protecting Memory T Cells from Spontaneous Apoptosis in Young and Old Mice
J. Immunol., September 1, 2005; 175(5): 2948 - 2959.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. D. Zhang, S.-C. Lo, Z. Sun, G. M. Habib, M. W. Lieberman, and M. Hannink
Ubiquitination of Keap1, a BTB-Kelch Substrate Adaptor Protein for Cul3, Targets Keap1 for Degradation by a Proteasome-independent Pathway
J. Biol. Chem., August 26, 2005; 280(34): 30091 - 30099.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Li, M. R. Jain, C. Chen, X. Yue, V. Hebbar, R. Zhou, and A.-N. T. Kong
Nrf2 Possesses a Redox-insensitive Nuclear Export Signal Overlapping with the Leucine Zipper Motif
J. Biol. Chem., August 5, 2005; 280(31): 28430 - 28438.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. Traka, A. V. Gasper, J. A. Smith, C. J. Hawkey, Y. Bao, and R. F. Mithen
Transcriptome Analysis of Human Colon Caco-2 Cells Exposed to Sulforaphane
J. Nutr., August 1, 2005; 135(8): 1865 - 1872.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Feng, Y. Lu, L. L. Bowman, Y. Qian, V. Castranova, and M. Ding
Inhibition of Activator Protein-1, NF-{kappa}B, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid
J. Biol. Chem., July 29, 2005; 280(30): 27888 - 27895.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J.-M. Lee, J. Li, D. A. Johnson, T. D. Stein, A. D. Kraft, M. J. Calkins, R. J. Jakel, and J. A. Johnson
Nrf2, a multi-organ protector?
FASEB J, July 1, 2005; 19(9): 1061 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Kirby, E. Halligan, M. J. Baptista, S. Allen, P. R. Heath, H. Holden, S. C. Barber, C. A. Loynes, C. A. Wood-Allum, J. Lunec, et al.
Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS
Brain, July 1, 2005; 128(7): 1686 - 1706.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. W. Fahey, K. K. Stephenson, A. T. Dinkova-Kostova, P. A. Egner, T. W. Kensler, and P. Talalay
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes
Carcinogenesis, July 1, 2005; 26(7): 1247 - 1255.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Y. Shih, S. Imbeault, V. Barakauskas, H. Erb, L. Jiang, P. Li, and T. H. Murphy
Induction of the Nrf2-driven Antioxidant Response Confers Neuroprotection during Mitochondrial Stress in Vivo
J. Biol. Chem., June 17, 2005; 280(24): 22925 - 22936.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Liby, T. Hock, M. M. Yore, N. Suh, A. E. Place, R. Risingsong, C. R. Williams, D. B. Royce, T. Honda, Y. Honda, et al.
The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling
Cancer Res., June 1, 2005; 65(11): 4789 - 4798.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. G. Banerjee, I. Bhattacharyya, and J. K. Vishwanatha
Identification of genes and molecular pathways involved in the progression of premalignant oral epithelia
Mol. Cancer Ther., June 1, 2005; 4(6): 865 - 875.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. H. Ki, I. J. Cho, D. W. Choi, and S. G. Kim
Glucocorticoid Receptor (GR)-Associated SMRT Binding to C/EBP{beta} TAD and Nrf2 Neh4/5: Role of SMRT Recruited to GR in GSTA2 Gene Repression
Mol. Cell. Biol., May 15, 2005; 25(10): 4150 - 4165.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Chen, E. Rubin, H. Zhang, S. Chung, C. C. Jie, E. Garrett, S. Biswal, and S. Sukumar
Identification of Transcriptional Targets of HOXA5
J. Biol. Chem., May 13, 2005; 280(19): 19373 - 19380.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. Li, M. L. Spletter, and J. A. Johnson
Dissecting tBHQ induced ARE-driven gene expression through long and short oligonucleotide arrays
Physiol Genomics, March 21, 2005; 21(1): 43 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. Calkins, R. J. Jakel, D. A. Johnson, K. Chan, Y. W. Kan, and J. A. Johnson
Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
PNAS, January 4, 2005; 102(1): 244 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. D. Zhang, S.-C. Lo, J. V. Cross, D. J. Templeton, and M. Hannink
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
Mol. Cell. Biol., December 15, 2004; 24(24): 10941 - 10953.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
G. K. McWalter, L. G. Higgins, L. I. McLellan, C. J. Henderson, L. Song, P. J. Thornalley, K. Itoh, M. Yamamoto, and J. D. Hayes
Transcription Factor Nrf2 Is Essential for Induction of NAD(P)H:Quinone Oxidoreductase 1, Glutathione S-Transferases, and Glutamate Cysteine Ligase by Broccoli Seeds and Isothiocyanates
J. Nutr., December 1, 2004; 134(12): 3499S - 3506S.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
W. Li, H. Amri, H. Huang, C. Wu, and V. Papadopoulos
Gene and Protein Profiling of the Response of MA-10 Leydig Tumor Cells to Human Chorionic Gonadotropin
J Androl, November 1, 2004; 25(6): 900 - 913.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. Bae, S. Fan, Q. Meng, J. K. Rih, H. J. Kim, H. J. Kang, J. Xu, I. D. Goldberg, A. K. Jaiswal, and E. M. Rosen
BRCA1 Induces Antioxidant Gene Expression and Resistance to Oxidative Stress
Cancer Res., November 1, 2004; 64(21): 7893 - 7909.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Li, J. Alam, M. I. Venkatesan, A. Eiguren-Fernandez, D. Schmitz, E. Di Stefano, N. Slaughter, E. Killeen, X. Wang, A. Huang, et al.
Nrf2 Is a Key Transcription Factor That Regulates Antioxidant Defense in Macrophages and Epithelial Cells: Protecting against the Proinflammatory and Oxidizing Effects of Diesel Exhaust Chemicals
J. Immunol., September 1, 2004; 173(5): 3467 - 3481.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
V. Svehlikova, S. Wang, J. Jakubikova, G. Williamson, R. Mithen, and Y. Bao
Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells
Carcinogenesis, September 1, 2004; 25(9): 1629 - 1637.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. C. Myzak, P. A. Karplus, F.-L. Chung, and R. H. Dashwood
A Novel Mechanism of Chemoprotection by Sulforaphane: Inhibition of Histone Deacetylase
Cancer Res., August 15, 2004; 64(16): 5767 - 5774.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. Hu, V. Hebbar, B.-R. Kim, C. Chen, B. Winnik, B. Buckley, P. Soteropoulos, P. Tolias, R. P. Hart, and A.-N. T. Kong
In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Sulforaphane in the Rat
J. Pharmacol. Exp. Ther., July 1, 2004; 310(1): 263 - 271.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
T. Yanagawa, K. Itoh, J. Uwayama, Y. Shibata, A. Yamaguchi, T. Sano, T. Ishii, H. Yoshida, and M. Yamamoto
Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ
Genes Cells, July 1, 2004; 9(7): 641 - 651.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Y. Zhang and G. B. Gordon
A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway
Mol. Cancer Ther., July 1, 2004; 3(7): 885 - 893.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-M. Lee, K. Chan, Y. W. Kan, and J. A. Johnson
Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia
PNAS, June 29, 2004; 101(26): 9751 - 9756.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. V. Singh, A. Herman-Antosiewicz, A. V. Singh, K. L. Lew, S. K. Srivastava, R. Kamath, K. D. Brown, L. Zhang, and R. Baskaran
Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C
J. Biol. Chem., June 11, 2004; 279(24): 25813 - 25822.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
W. H. M. Heijne, A. L. Slitt, P. J. van Bladeren, J. P. Groten, C. D. Klaassen, R. H. Stierum, and B. van Ommen
Bromobenzene-Induced Hepatotoxicity at the Transcriptome Level
Toxicol. Sci., June 1, 2004; 79(2): 411 - 422.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. G. Petrich, B. C. Eloff, D. L. Lerner, A. Kovacs, J. E. Saffitz, D. S. Rosenbaum, and Y. Wang
Targeted Activation of c-Jun N-terminal Kinase in Vivo Induces Restrictive Cardiomyopathy and Conduction Defects
J. Biol. Chem., April 9, 2004; 279(15): 15330 - 15338.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Gebel, B. Gerstmayer, A. Bosio, H.-J. Haussmann, E. V. Miert, and T. Muller
Gene expression profiling in respiratory tissues from rats exposed to mainstream cigarette smoke
Carcinogenesis, February 1, 2004; 25(2): 169 - 178.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. V. Singh, D. Xiao, K. L. Lew, R. Dhir, and S. V. Singh
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
Carcinogenesis, January 1, 2004; 25(1): 83 - 90.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M.-K. Kwak, N. Wakabayashi, J. L. Greenlaw, M. Yamamoto, and T. W. Kensler
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway
Mol. Cell. Biol., December 1, 2003; 23(23): 8786 - 8794.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. D. Zhang and M. Hannink
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
Mol. Cell. Biol., November 15, 2003; 23(22): 8137 - 8151.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
I. R. Jowsey, Q. Jiang, K. Itoh, M. Yamamoto, and J. D. Hayes
Expression of the Aflatoxin B1-8,9-Epoxide-Metabolizing Murine Glutathione S-Transferase A3 Subunit Is Regulated by the Nrf2 Transcription Factor through an Antioxidant Response Element
Mol. Pharmacol., November 1, 2003; 64(5): 1018 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. A. Haas, M. Hild, A. P. H. Wright, T. Hain, D. Talibi, and M. Vingron
Genome-scale design of PCR primers and long oligomers for DNA microarrays
Nucleic Acids Res., October 1, 2003; 31(19): 5576 - 5581.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E.M.J. van der Logt, H.M.J. Roelofs, F.M. Nagengast, and W.H.M. Peters
Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens
Carcinogenesis, October 1, 2003; 24(10): 1651 - 1656.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-M. Lee, A. Y. Shih, T. H. Murphy, and J. A. Johnson
NF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons
J. Biol. Chem., September 26, 2003; 278(39): 37948 - 37956.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. J. Hintze, K. A. Wald, H. Zeng, E. H. Jeffery, and J. W. Finley
Thioredoxin Reductase in Human Hepatoma Cells Is Transcriptionally Regulated by Sulforaphane and Other Electrophiles via an Antioxidant Response Element-
J. Nutr., September 1, 2003; 133(9): 2721 - 2727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Srisuma, S. S. Biswal, W. A. Mitzner, S. J. Gallagher, K. H. Mai, and E. M. Wagner
Identification of Genes Promoting Angiogenesis in Mouse Lung by Transcriptional Profiling
Am. J. Respir. Cell Mol. Biol., August 1, 2003; 29(2): 172 - 179.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. H. An and T. K. Blackwell
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
Genes & Dev., August 1, 2003; 17(15): 1882 - 1893.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. McMahon, K. Itoh, M. Yamamoto, and J. D. Hayes
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
J. Biol. Chem., June 6, 2003; 278(24): 21592 - 21600.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Y. Shih, D. A. Johnson, G. Wong, A. D. Kraft, L. Jiang, H. Erb, J. A. Johnson, and T. H. Murphy
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress
J. Neurosci., April 15, 2003; 23(8): 3394 - 3406.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E. M. Ellis, C. M. Slattery, and J. D. Hayes
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter
Carcinogenesis, April 1, 2003; 24(4): 727 - 737.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-M. Lee, M. J. Calkins, K. Chan, Y. W. Kan, and J. A. Johnson
Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis
J. Biol. Chem., March 28, 2003; 278(14): 12029 - 12038.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-K. Kwak, N. Wakabayashi, K. Itoh, H. Motohashi, M. Yamamoto, and T. W. Kensler
Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway. IDENTIFICATION OF NOVEL GENE CLUSTERS FOR CELL SURVIVAL
J. Biol. Chem., February 28, 2003; 278(10): 8135 - 8145.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Allen, P. R. Heath, J. Kirby, S. B. Wharton, M. R. Cookson, F. M. Menzies, R. E. Banks, and P. J. Shaw
Analysis of the Cytosolic Proteome in a Cell Culture Model of Familial Amyotrophic Lateral Sclerosis Reveals Alterations to the Proteasome, Antioxidant Defenses, and Nitric Oxide Synthetic Pathways
J. Biol. Chem., February 14, 2003; 278(8): 6371 - 6383.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. C. Pietsch, J. Y. Chan, F. M. Torti, and S. V. Torti
Nrf2 Mediates the Induction of Ferritin H in Response to Xenobiotics and Cancer Chemopreventive Dithiolethiones
J. Biol. Chem., January 17, 2003; 278(4): 2361 - 2369.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2002 by the American Association for Cancer Research.