| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Meeting Report |
Comprehensive Cancer Center, Cardiovascular Research Institute, and Department of Anatomy, University of California, San Francisco, California 94143
ABSTRACT
Despite major advances in the field of tumor angiogenesis, relatively little attention has been paid to the permeability of blood vessels in tumors. The leakiness of tumor vessels is well documented in experimental tumor models and in human cancer, but the mechanism is poorly understood, as are the implications to the rate of cancer growth, predisposition to metastasis, and delivery of macromolecular therapeutics to tumor cells. Sixteen experts in the fields of cancer biology and vascular biology gathered at the William Guy Forbeck "Focus on the Future" Conference to discuss this topic. The meeting was the first of its kind focused on the significance of blood vessel leakiness in tumors. The participants discussed the cellular basis of tumor vessel leakiness, endothelial barrier function of blood vessels, monitoring tumor vessel leakiness, mediators of endothelial leakiness, consequences of tumor vessel leakiness, genomic analysis of vascular targets, targeting drugs to tumor vessels, and therapeutic manipulation of tumor vessels. The group concluded that a more complete understanding of the basic biology of tumor vessels will be necessary to fully appreciate the consequences of vessel leakiness in cancer. New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding.
This article has been cited by other articles:
|
|
 |
|
  D. TILKI, M. SEITZ, B. B. SINGER, S. IRMAK, C. G. STIEF, O. REICH, and S. ERGUN Molecular Imaging of Tumor Blood Vessels in Prostate Cancer Anticancer Res, May 1, 2009; 29(5): 1823 - 1829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Zolnik, S. T. Stern, J. M. Kaiser, Y. Heakal, J. D. Clogston, M. Kester, and S. E. McNeil Rapid Distribution of Liposomal Short-Chain Ceramide in Vitro and in Vivo Drug Metab. Dispos., August 1, 2008; 36(8): 1709 - 1715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Bagley, C. Rouleau, T. St. Martin, P. Boutin, W. Weber, M. Ruzek, N. Honma, M. Nacht, S. Shankara, S. Kataoka, et al. Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248 Mol. Cancer Ther., August 1, 2008; 7(8): 2536 - 2546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Strieth, M. E. Eichhorn, A. Werner, B. Sauer, M. Teifel, U. Michaelis, A. Berghaus, and M. Dellian Paclitaxel Encapsulated in Cationic Liposomes Increases Tumor Microvessel Leakiness and Improves Therapeutic Efficacy in Combination with Cisplatin Clin. Cancer Res., July 15, 2008; 14(14): 4603 - 4611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Tran, C. D. Smith, M. Kester, and G. P. Robertson Combining Nanoliposomal Ceramide with Sorafenib Synergistically Inhibits Melanoma and Breast Cancer Cell Survival to Decrease Tumor Development Clin. Cancer Res., June 1, 2008; 14(11): 3571 - 3581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chen, M. S. Jamaluddin, S. Yan, D. Sheikh-Hamad, and Q. Yao Human Stanniocalcin-1 Blocks TNF-{alpha}-Induced Monolayer Permeability in Human Coronary Artery Endothelial Cells Arterioscler. Thromb. Vasc. Biol., May 1, 2008; 28(5): 906 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H.E. Baker, K. E. Lindquist, L. A. Huxham, A. H. Kyle, J. T. Sy, and A. I. Minchinton Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts Clin. Cancer Res., April 1, 2008; 14(7): 2171 - 2179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Thomas, M. J. Ogagan, M. L. Freilino, S. Strychor, D. R. Walsh, W. E. Gooding, J. R. Grandis, and W. C. Zamboni Antitumor Mechanisms of Systemically Administered Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck Mol. Pharmacol., March 1, 2008; 73(3): 627 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Bullitt, N. U. Lin, J. K. Smith, D. Zeng, E. P. Winer, L. A. Carey, W. Lin, and M. G. Ewend Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases: A Feasibility Study Radiology, December 1, 2007; 245(3): 824 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. DeWever, F. Frerart, C. Bouzin, C. Baudelet, R. Ansiaux, P. Sonveaux, B. Gallez, C. Dessy, and O. Feron Caveolin-1 Is Critical for the Maturation of Tumor Blood Vessels through the Regulation of Both Endothelial Tube Formation and Mural Cell Recruitment Am. J. Pathol., November 1, 2007; 171(5): 1619 - 1628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Law, R. Young, J. Babb, M. Rad, T. Sasaki, D. Zagzag, and G. Johnson Comparing Perfusion Metrics Obtained from a Single Compartment Versus Pharmacokinetic Modeling Methods Using Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging with Glioma Grade. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1975 - 1982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Cassoni, T. Marrocco, B. Bussolati, E. Allia, L. Munaron, A. Sapino, and G. Bussolati Oxytocin Induces Proliferation and Migration in Immortalized Human Dermal Microvascular Endothelial Cells and Human Breast Tumor-Derived Endothelial Cells Mol. Cancer Res., June 1, 2006; 4(6): 351 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Wagner, G. Karagulova, J. Jenkins, J. Bishai, and J. McClintock Changes in lung permeability after chronic pulmonary artery obstruction J Appl Physiol, April 1, 2006; 100(4): 1224 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schmidt, J. Hoffend, A. Altmann, L. G. Strauss, A. Dimitrakopoulou-Strauss, B. Engelhardt, D. Koczan, J. Peter, T. J. Dengler, W. Mier, et al. Angiostatin Overexpression in Morris Hepatoma Results in Decreased Tumor Growth but Increased Perfusion and Vascularization J. Nucl. Med., March 1, 2006; 47(3): 543 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nakahara, S. M. Norberg, D. R. Shalinsky, D. D. Hu-Lowe, and D. M. McDonald Effect of Inhibition of Vascular Endothelial Growth Factor Signaling on Distribution of Extravasated Antibodies in Tumors Cancer Res., February 1, 2006; 66(3): 1434 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Chen, B. W. Pogue, J. M. Luna, R. L. Hardman, P. J. Hoopes, and T. Hasan Tumor Vascular Permeabilization by Vascular-Targeting Photosensitization: Effects, Mechanism, and Therapeutic Implications Clin. Cancer Res., February 1, 2006; 12(3): 917 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sacchi, A. Gasparri, C. Gallo-Stampino, S. Toma, F. Curnis, and A. Corti Synergistic Antitumor Activity of Cisplatin, Paclitaxel, and Gemcitabine with Tumor Vasculature-Targeted Tumor Necrosis Factor-{alpha} Clin. Cancer Res., January 1, 2006; 12(1): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. McDonald and P. Baluk Imaging of Angiogenesis in Inflamed Airways and Tumors: Newly Formed Blood Vessels Are Not Alike and May Be Wildly Abnormal: Parker B. Francis Lecture Chest, December 1, 2005; 128(6_suppl): 602S - 608S. [Full Text] [PDF]
|
|
|
|
|
|
P. Parsons-Wingerter, I. M. Kasman, S. Norberg, A. Magnussen, S. Zanivan, A. Rissone, P. Baluk, C. J. Favre, U. Jeffry, R. Murray, et al. Uniform Overexpression and Rapid Accessibility of {alpha}5{beta}1 Integrin on Blood Vessels in Tumors Am. J. Pathol., July 1, 2005; 167(1): 193 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Abramowicz Ultrasonographic Contrast Media: Has the Time Come in Obstetrics and Gynecology? J. Ultrasound Med., April 1, 2005; 24(4): 517 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hida and M. Klagsbrun A New Perspective on Tumor Endothelial Cells: Unexpected Chromosome and Centrosome Abnormalities Cancer Res., April 1, 2005; 65(7): 2507 - 2510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Smith, R. E. Kontermann, J. Embleton, and S. Kumar Antibody phage display technologies with special reference to angiogenesis FASEB J, March 1, 2005; 19(3): 331 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Waschke, D. Drenckhahn, R. H. Adamson, H. Barth, and F. E. Curry cAMP protects endothelial barrier functions by preventing Rac-1 inhibition Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2427 - H2433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hida, Y. Hida, D. N. Amin, A. F. Flint, D. Panigrahy, C. C. Morton, and M. Klagsbrun Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities Cancer Res., November 15, 2004; 64(22): 8249 - 8255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-Y. Lee, H.-C. Wu, Y.-L. Tseng, and C.-T. Lin A Novel Peptide Specifically Binding to Nasopharyngeal Carcinoma For Targeted Drug Delivery Cancer Res., November 1, 2004; 64(21): 8002 - 8008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Robinson, L. E. Reynolds, L. Wyder, D. J. Hicklin, and K. M. Hodivala-Dilke {beta}3-Integrin Regulates Vascular Endothelial Growth Factor-A-Dependent Permeability Arterioscler. Thromb. Vasc. Biol., November 1, 2004; 24(11): 2108 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Law, K. Kazmi, S. Wetzel, E. Wang, C. Iacob, D. Zagzag, J. G. Golfinos, and G. Johnson Dynamic Susceptibility Contrast-Enhanced Perfusion and Conventional MR Imaging Findings for Adult Patients with Cerebral Primitive Neuroectodermal Tumors AJNR Am. J. Neuroradiol., June 1, 2004; 25(6): 997 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Law, S. Yang, J. S. Babb, E. A. Knopp, J. G. Golfinos, D. Zagzag, and G. Johnson Comparison of Cerebral Blood Volume and Vascular Permeability from Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging with Glioma Grade AJNR Am. J. Neuroradiol., May 1, 2004; 25(5): 746 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Wahl, T. L. Moser, and S. V. Pizzo Angiostatin and Anti-angiogenic Therapy in Human Disease Recent Prog. Horm. Res., January 1, 2004; 59(1): 73 - 104. [Abstract] [Full Text]
|
|
|
|
|
|
A. W. B. Stanton, S. B. Drysdale, R. Patel, R. H. Mellor, M. J. B. Duff, J. R. Levick, and P. S. Mortimer Expansion of Microvascular Bed and Increased Solute Flux in Human Basal Cell Carcinoma in Vivo, Measured by Fluorescein Video Angiography Cancer Res., July 15, 2003; 63(14): 3969 - 3979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Hammond, M. J. Dorie, and A. J. Giaccia ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation J. Biol. Chem., March 28, 2003; 278(14): 12207 - 12213. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
